Navigation Links
Scientists discover molecular 'switch' that contributes to cellular aging process
Date:11/30/2010

ative stress. The researchers were able to reduce the negative effects of oxidative stress by giving antioxidants or drugs known to turn the protective activities of PPARs back on.

The scientists knew that oxidative damage causes the body to age. What they did not know is why aged cells have more oxidative damage. "The significance of our study is that we show SMRT facilitates this process," Lee said. "In other words, the normal metabolic homeostasis is maintained, in part, by PPARs. SMRT acts as a metabolic switch to turn off PPAR activities when the cells age."

PPAR drugs have been used to increase insulin sensitivity and lower blood lipid levels. "Our study shows PPARs might also be used to boost the body's ability to handle oxidative stress," Lee said.

"With what we have learned, we believe SMRT is one of the key players that causes age-dependent decline in mitochondrial function by blocking PPAR activity, and we've found a way to boost the body's ability to better handle metabolic and oxidative stress," Lee said. "This finding is significant since increased oxidative stress, coupled with reduced metabolic function, contributes to the aging process and the development of age-related metabolic diseases."

In collaboration with epidemiologists at HSPH, the team found genetic variations in the human SMRT gene that are associated with risk of type 2 diabetes. "Through this study we were able to validate that our findings in the animal model apply to human diseases," Lee said.


'/>"/>

Contact: Marjorie Dwyer
mhdwyer@hsph.harvard.edu
617-384-8995
Harvard School of Public Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists redefine the role of plasma cells in the immune system
2. U of I scientists develop tool to trace metabolism of cancer-fighting tomato compounds
3. Duke scientists look deeper for coal ash hazards
4. Scientists discover new mechanism for controlling blood sugar level
5. Scientists question fisheries health test
6. Scientists clock on to how sunlight shapes daily rhythms
7. Scientists discover genes linking puberty timing to body fat in women
8. Bacteria use toxic darts to disable each other, according to UCSB scientists
9. Scientists question indicator of fisheries health, evidence for fishing down food webs
10. Scientists learn more about how kidneys fail and how new drugs may intervene
11. Scripps Research scientists identify new mechanism regulating daily biological rhythms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2015)... DALLAS , February 11, 2015 /PRNewswire/ ... market research report "Access Control Market by Product ... (Commercial, Residential, Military and Defense, Government, Industrial, Healthcare, ... , published by MarketsandMarkets, the Access Control ... by 2020, growing at a CAGR of ...
(Date:2/5/2015)... TRIANGLE PARK, N.C. , Feb. 5, 2015 /PRNewswire/ ... a specialist logistics company and has launched a new ... only Clinical Logistics Organization (CLO).  The new campaign focuses ... emphasis on patient, protocol and shipments. The ... First , aligns Marken,s priorities with its client,s ...
(Date:2/5/2015)... FRANCISCO , January 28, 2015 ... Market Analysis, Size And Segment Forecasts To 2020 has ... global IR camera market is expected to reach USD ... by Grand View Research, Inc. IR cameras help identify ... and are expected to witness surging demand in medical ...
Breaking Biology News(10 mins):Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken Launches New Patient-Centric Campaign 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3
... degrees Celsius. But not salt water: Due to ... is below zero. And sea water tends to freeze ... so-called "brine channels," are formed in the ice. The ... remain in a liquid state even at lower temperatures, and ...
... satellite data, a team of scientists led by researchers from ... created a model that can successfully predict the severity and ... the rest of South America months in advance. ... the primary factor that drives the distribution of fires in ...
... rely on animals for pollination, the number of seeds they ... and the successful deposition of pollen. The number of visits ... well as on conspecific plant density. But what if a ... or has very few pollinators visiting its flowers? Will all ...
Cached Biology News:CO2 bonds in sea ice: Small living creatures with major impact 2Ocean temperatures can predict Amazon fire season severity 2Ocean temperatures can predict Amazon fire season severity 3How does a plant survive with few mates or pollinators? A European herb has figured out its own way 2How does a plant survive with few mates or pollinators? A European herb has figured out its own way 3
(Date:3/4/2015)... 04, 2015 PRC Clinical, ... San Francisco Bay Area, will exhibit and present at ... 2015 on March 25th and 26th in Tel ... relationships with Israeli life science companies seeking to conduct ... company’s services span all phases of human trials, from ...
(Date:3/4/2015)... 4, 2015 Vegalab announced the acquisition of ... last year. As part of the acquisition, Ecowin rebranded ... continuing his role as CEO for the company,s Korea ... will work alongside Koo and oversee developments at the ... Koo founded Ecowin in 2008 ...
(Date:3/4/2015)...   ... Therapie, Strahlendosismanagement und IT-Lösungen für die gesamte Kette ... (NYSE: PHG, AEX: PHIA) gab heute seine ... bekannt, der vom 4. bis 8. März in ... Nr. 102 and 110 wird das Unternehmen ...
(Date:3/3/2015)... Experts and industry insiders from around ... the Alltech REBELation exploring innovation, inspiration and world-changing ideas ... its 31st year, Alltech’s annual international conference traditionally draws ... opportunity to join the REBELation at an extra discount ... EST, at which point the standard early registration rate ...
Breaking Biology Technology:PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 2PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 3PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 4Korean Government Program Supports Vegalab's Research and Development 2Korean Government Program Supports Vegalab's Research and Development 3Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 2Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 3Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 4Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 5Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 6World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4
... Nov. 2, 2011 Cadence Pharmaceuticals, Inc. (NASDAQ: ... developing and commercializing proprietary products principally for use in ... and CEO Ted Schroeder will present the company,s corporate ... Time (3:30pm Eastern Time) during the Credit Suisse Healthcare ...
... 2011 Quanterix Corporation, a company enabling a ... its revolutionary Si ngle Mo lecule ... analytical performance of its Prostate Specific Antigen (PSA) ... improvement in sensitivity over today,s ultrasensitive third-generation PSA ...
... In preparation for its European launch ... 50 years, Human Genome Sciences (HGS) needed a customer ... European commercial sales team. The company had a long ... mobility, industry-specific functionality, speed, and low system maintenance. Veeva ...
Cached Biology Technology:Quanterix Fifth-Generation PSA Test Enables More Sensitive Measurements Following Surgery 2Human Genome Sciences Europe Moves to the Cloud With Veeva CRM to Support New Lupus Treatment 2Human Genome Sciences Europe Moves to the Cloud With Veeva CRM to Support New Lupus Treatment 3
... 'Agilents GeneSpring Workgroup solution is ... managing and mining expression data in ... and is deployed in over 40 ... research organizations worldwide. GeneSpring Workgroup streamlines ...
... LC Sciences provides a genome-wide microRNA ... and proprietary probe design, which enable highly ... (1-3). We have standard arrays for mature ... latest version of the Sanger miRBase database ...
... ProXPRESS 2D Proteomic Imaging System, Basic Package ... a Wide Dynamic Range: The ProXPRESS 2D ... in imaging system for both proteomic and ... provides unparalleled flexibility, enabling the use of ...
... microarrays are custom designed to meet your ... available: 8,455 features per array (2 arrays/1" ... per array (1 array/slide). Features ... - This extended length delivers higher ...
Biology Products: