Navigation Links
Scientists discover molecular 'switch' that contributes to cellular aging process
Date:11/30/2010

ative stress. The researchers were able to reduce the negative effects of oxidative stress by giving antioxidants or drugs known to turn the protective activities of PPARs back on.

The scientists knew that oxidative damage causes the body to age. What they did not know is why aged cells have more oxidative damage. "The significance of our study is that we show SMRT facilitates this process," Lee said. "In other words, the normal metabolic homeostasis is maintained, in part, by PPARs. SMRT acts as a metabolic switch to turn off PPAR activities when the cells age."

PPAR drugs have been used to increase insulin sensitivity and lower blood lipid levels. "Our study shows PPARs might also be used to boost the body's ability to handle oxidative stress," Lee said.

"With what we have learned, we believe SMRT is one of the key players that causes age-dependent decline in mitochondrial function by blocking PPAR activity, and we've found a way to boost the body's ability to better handle metabolic and oxidative stress," Lee said. "This finding is significant since increased oxidative stress, coupled with reduced metabolic function, contributes to the aging process and the development of age-related metabolic diseases."

In collaboration with epidemiologists at HSPH, the team found genetic variations in the human SMRT gene that are associated with risk of type 2 diabetes. "Through this study we were able to validate that our findings in the animal model apply to human diseases," Lee said.


'/>"/>

Contact: Marjorie Dwyer
mhdwyer@hsph.harvard.edu
617-384-8995
Harvard School of Public Health
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Scripps Research scientists redefine the role of plasma cells in the immune system
2. U of I scientists develop tool to trace metabolism of cancer-fighting tomato compounds
3. Duke scientists look deeper for coal ash hazards
4. Scientists discover new mechanism for controlling blood sugar level
5. Scientists question fisheries health test
6. Scientists clock on to how sunlight shapes daily rhythms
7. Scientists discover genes linking puberty timing to body fat in women
8. Bacteria use toxic darts to disable each other, according to UCSB scientists
9. Scientists question indicator of fisheries health, evidence for fishing down food webs
10. Scientists learn more about how kidneys fail and how new drugs may intervene
11. Scripps Research scientists identify new mechanism regulating daily biological rhythms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Inside the natural history museums of the world are ... and beetles to flowers, mushrooms and grasses, all stacked, ... The rich and diverse collections could be critical to ... face of a growing human footprint if only ... project, brought to life with the help of a ...
(Date:5/23/2013)... MADISON, Wis. In an age when microbial pathogens ... to tamp down infection, a team of Wisconsin scientists ... of curbing the bacteria that cause staph infections. , ... Chemical Society , a group led by University of ... interfere with the "quorum sensing" behavior of Staphylococcus ...
(Date:5/22/2013)... Researchers working to improve durability in fuel cell ... University, have discovered links between electrode degradation processes ... quantifying the effects of electrode degradation stressors in ... membrane lifetime. , The findings of the study, ... the latest in a long-term study at Burnaby-based ...
Breaking Biology News(10 mins):CU-Boulder helps tap crowds to digitize museum records of bugs and plants 2CU-Boulder helps tap crowds to digitize museum records of bugs and plants 3CU-Boulder helps tap crowds to digitize museum records of bugs and plants 4University of Wisconsin chemists find new compounds to curb staph infection 2Tests lead to doubling of fuel cell life 2
... by factor of 10 billion,New research published in ... that tailored nanoparticles known as nanoshells can,enhance chemical ... That makes,them about 10,000 times more effective at ... scatter light, a small fraction of the light,interacts ...
... will be "labs-on-a-chip", i.e., integrated chemical and biochemical ... computer chip. An essential prerequisite for such labs ... small amounts of liquids and chemical reagents. Directly ... available photolithographic methods, represent an appealing design principle ...
... testosterone (Ed : testosterone isn't a protein, it's ... that allows it to function properly. Now Stanford University ... color when a protein molecule attached to a gold ... on the same principle as ordinary pH tests that ...
Cached Biology News:Study shows nanoshells ideal as chemical nanosensors 2Open microfluidic and nanofluidic systems 2Open microfluidic and nanofluidic systems 3Open microfluidic and nanofluidic systems 4Scientists develop new color-coded test for protein folding 2
(Date:5/23/2013)... May 23, 2013 Graphite Metallizing ... self-lubricating bushings mounted in stainless steel pillow blocks. ... of GRAPHALLOY with the application and installation versatility ... Pillow Blocks work exceptionally well when submerged ... hostile liquids such as acids, alkalies, hydrocarbons, black ...
(Date:5/23/2013)... BROWNSBURG, Ind. , May 23, 2013  Rahal ... leader in human cord blood stem cell banking and ... sponsor of the No. 16 Acorn Stairlifts Indy car ... is for the remainder of the IZOD IndyCar 2013 ... Racing (RLL) will work to support awareness of umbilical ...
(Date:5/23/2013)... MARINO, Calif. , May 23, 2013 /PRNewswire/ ... today a strategic alliance with DAK Renewable Research ... the corn oil yield. VG Energy is a ... (OTC Pink: VGLS). VG Energy,s exclusively ... to increase the oil yield in plants, possessing ...
(Date:5/23/2013)... BioTrends Research Group, one of the ... biopharmaceutical issues, finds that, unaided, one in five ... that in the past six months, they have ... anticipation of the next generation of HCV treatments—notably ... 6 percent reported that they had begun warehousing ...
Breaking Biology Technology:Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 2Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 3StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 2StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 3VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 2VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 3The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 3
... HAIKOU CITY, China, July 2 /Xinhua-PRNewswire-FirstCall/,-- China Pharma ... develops, manufactures, and markets generic and branded bio-,pharmaceutical ... will,present at the Collins Stewart Fourth Annual Growth ... The conference is being held at the Mandarin,Oriental ...
... Marketing and Sales; Susan Koppy ... President, Corporate Development, PT. RICHMOND, Calif., July 2 ... the position of,Vice President, Marketing and Sales and Susan Koppy ... and Ms. Koppy will report,to President & Chief Executive Officer ...
... From Allied Minds to Commercialize Novel Technology for the Extraction of ... ... BOSTON, July 2 Allied Minds, a pre-seed investment,corporation specializing in ... Northeastern,University announce the creation of CryoXtract Instruments, LLC, a new,spin-out focused ...
Cached Biology Technology:China Pharma Holdings, Inc. to Present at Collins Stewart Fourth Annual Growth Conference in New York on July 8, 2008 at 2:00 p.m. EDT 2Transcept Pharmaceuticals Appoints Key Senior Executives 2Transcept Pharmaceuticals Appoints Key Senior Executives 3Transcept Pharmaceuticals Appoints Key Senior Executives 4Investment Firm Allied Minds to Commercialize New Frozen Aliquotter Technology with Two Local Major Universities. 2
... is a direct antibiotic-based ... identification. Recombinant selection depends ... eliminating the need for ... quick and inexpensive process ...
... Qentix Western Blot Signal Enhancer does for enzyme-/substrate-based ... it increases the signal up to 10-fold ... minutes., ,The Western Blot Signal Enhancer membrane ... be added to your current Western blotting ...
... multi-functional program that searches for ... sequence file for polymerase chain ... mutagenesis, and various hybridization applications. ... secondary structure of oligonucleotides based ...
...
Biology Products: