Navigation Links
Scientists discover major clue in long-term memory making
Date:3/20/2011

DURHAM, N.C. You may remember the color of your loved one's eyes for years. But how?

Scientists believe that long-term potentiation (LTP) the long-lasting increase of signals across a connection between brain cells -- underlies our ability to remember over time and to learn, but how that happens is a central question in neuroscience.

Researchers at Duke University Medical Center have found a cascade of signaling molecules that allows a usually very brief signal to last for tens of minutes, providing the brain framework for stronger connections (synapses) that can summon a memory for a period of months or even years.

Their findings about how the synapses change the strength of connections could have a bearing on Alzheimer's disease, autism and mental retardation, said Ryohei Yasuda, Ph.D., assistant professor of neurobiology and senior author.

"We found that a biochemical process that lasts a long time is what causes memory storage," said Yasuda, who is a Howard Hughes Medical Institute Early Career Scientist.

This work was published in the March 20 issue of Nature.

The researchers were investigating the signaling molecules that regulate the actin cytoskeleton, which serves as the structural framework of synapses.

"The signaling molecules could help to rearrange the framework, and give more volume and strength to the synapses," Yasuda said. "We reasoned that a long-lasting memory could possibly come from changes in the building block assemblies."

The Duke researchers knew that long-term potentiation, a long-lasting set of electrical impulses in nerve cells, is triggered by a transient increase of calcium (Ca2+) ions in a synapse. They devised experiments to learn exactly how the short Ca2+ signal, which lasts only for ~0.1s, is translated into long-lasting (more than an hour) change in synaptic transmission.

The team used a 2-photon microscopy technique to visualize molecular signaling within single synapses undergoing LTP, a method developed in the Yasuda lab. This microscopy method allowed the team to monitor molecular activity in single synapses while measuring the synapses for increase in their volume and strength of the connections.

They found that signaling molecules Rho and Cdc42, regulators of the actin cytoskeleton, are activated by CaMKII, and relay a CaMKII signal into signals lasting many minutes. These long-lasting signals are important for maintaining long-lasting plasticity of synapses, the ability of the brain to change during learning or memorization.

Many mental diseases such as mental retardation and Alzheimer's disease are associated with abnormal Rho and Cdc42 signals, Yasuda said. "Thus, our finding will provide many insights into these diseases."


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert  

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists discover major clue in long-term memory making
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... Controller General of Immigration from Maldives Mr. Mohamed Anwar and ... international IAIR Award for the most innovative high security ePassport and eGates  ... ... Maldives Immigration Controller General, Mr. Mohamed Anwar ... right) have received the IAIR award for the "Most innovative high security ...
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition and ... Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the market ... CAGR of 29.63% between 2017 and 2022. Continue ... ... ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... NY (PRWEB) , ... October 12, 2017 , ... ... of Sciences today announced the three Winners and six Finalists of the 2017 ... given annually by the Blavatnik Family Foundation and administered by the New York ...
(Date:10/12/2017)... ... 12, 2017 , ... AMRI, a global contract research, development ... patient outcomes and quality of life, will now be offering its impurity solutions ... new regulatory requirements for all new drug products, including the finalization of ICH ...
(Date:10/11/2017)... ... , ... Personal eye wash is a basic first aid supply for any work environment, but ... do you rinse first if a dangerous substance enters both eyes? It’s one less decision, ... its unique dual eye piece. , “Whether its dirt and debris, or an acid or ...
(Date:10/11/2017)... ROTTERDAM, the Netherlands and LAGUNA HILLS, ... that The Institute of Cancer Research, London ... will use MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify ... high-risk trial known as MUK nine . The University ... this trial, which is partly funded by Myeloma UK, and ...
Breaking Biology Technology: