Navigation Links
Scientists discover key factor in regulating placenta and fetal growth
Date:9/20/2009

Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) have shown that a common biological protein molecule called SHP-2 is crucial for encouraging placenta growth. The research is published today in Endocrinology.

Dr Melissa Westwood, one of the team at the University of Manchester said: "For fetuses to grow well in the womb they need to get nutrients and oxygen from their mother. These come via the placenta and so as the fetus grows and its demand on mum increases, the placenta also must increase in size. If the placenta doesn't grow properly, the fetus is unable to receive all it needs from the mother and its growth is restricted. This can impact seriously on the health of the newborn. Furthermore we have learned recently that it dramatically increases the risk of ill health in adult life."

The researchers have investigated a group of proteins called the insulin-like growth factors (IGF). They have discovered that SHP-2, a molecule within placental cells, is a crucial mediator of the effects of IGFs in stimulating the placenta to grow.

Dr Westwood continued: "We know that placentas need an array of factors to support their growth, but until now we didn't realise that SHP-2 was so important for ensuring that these factors do their job.

"Research from our lab and others around the world suggests that the placentas of growth-restricted babies might not grow because they are resistant to the effects of growth factors. We know that in many tissues in the body, SHP-2 is involved with the action of other growth factors not just IGF. Targeting the mediators of growth factor actions rather than the growth factors themselves may be a good way to intervene in cases of growth restriction a bit like sending a positive email to all your friends at the same time.

"However, any therapy based on this finding would have to be designed carefully. Most tissues of the body have SHP-2 doing one
'/>"/>

Contact: nancy mendoza
press.office@bbsrc.ac.uk
01-793-413-355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists find that individuals in vegetative states can learn
2. UCLA scientists make paralyzed rats walk again after spinal-cord injury
3. Scientists pinpoint protein link to fat storage
4. Impact of renewable energy on our oceans must be investigated, say scientists
5. UT scientists discover link between protein and lung disease
6. Alert status area in brain discoved by Hebrew University scientists
7. Master gene that switches on disease-fighting cells identified by scientists
8. Scientists seek new emphases in Arctic climate change research
9. Superscanner helps scientists see into the unknown
10. Scientists use microRNAs to track evolutionary history for first time
11. Michigan Tech scientists identify genes linked to Lou Gehrigs disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... cell,s nucleus, chromosomal DNA is tightly bound to ... call chromatin. Until about two decades ago, histones ... packing material around which the glamorous DNA strands ... greater appreciation for how DNA/histone interactions govern gene ... institutions studying the sequence of the genome from ...
(Date:8/29/2014)... of the Tibetan plateau -- the largest topographic anomaly ... both its profound effect on climate and its reflection ... GSA Bulletin , Katharine Huntington and colleagues employ a ... modern and fossil snail shells to investigate the uplift ... , Views range widely on the timing of surface ...
(Date:8/28/2014)... pleased to announce the selection of Dr. Fred Baxendale ... acknowledges those who have served ESA for at least ... the Society that has reached an extraordinary level. Candidates ... Board and then voted on by the ESA membership. ... at Entomology 2014, ESA,s Annual Meeting in Portland, Oregon ...
Breaking Biology News(10 mins):'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Fred Baxendale selected as Honorary Member of the Entomological Society of America 2
... , April 27 ARES Corporation ... operations division has been certified to the rigorous ... ISO 9001:2008 quality standard.  This certification signifies ARES, ... standards and strengthens our competitive position by standardizing ...
... , HOUSTON , April 27 Landry,s ... "Company") announced today that after lengthy negotiations with the Special ... the plaintiff in a lawsuit pending in Delaware , ... with the plaintiff,s attorneys to settle the stockholder derivative claim ...
... NEW YORK, April 27, 2010 The Juvenile Diabetes ... Living Cell Technologies (LCT), a New Zealand-based biotechnology company ... II clinical trial to study the safety and effectiveness ... treatment for type 1 diabetes with significant hypoglycemia unawareness. ...
Cached Biology News:ARES Aerospace and Defense Division Receives AS9100 Certification 2Landry's Restaurants, Inc. Announces Status of Acquisition by Tilman J. Fertitta and Tentative Partial Settlement of Delaware Lawsuit 2Landry's Restaurants, Inc. Announces Status of Acquisition by Tilman J. Fertitta and Tentative Partial Settlement of Delaware Lawsuit 3Landry's Restaurants, Inc. Announces Status of Acquisition by Tilman J. Fertitta and Tentative Partial Settlement of Delaware Lawsuit 4JDRF partners with LCT to test encapsulated cell replacement therapy for the treatment of diabetes 2JDRF partners with LCT to test encapsulated cell replacement therapy for the treatment of diabetes 3
(Date:8/28/2014)... research platform uses a laser to measure ... stress and heating, an approach likely to ... and batteries., This new technique, called nanomechanical ... and the surface stress of microscale structures ... the merits of surface-stress influence on mechanical ...
(Date:8/28/2014)... The ability for organizations to attract ... allow individuals to perform at the highest of levels, ... looking to compete in this post–recession era. The ... as the sector increasingly focuses on the importance of ... have real results on the organization's development and the ...
(Date:8/28/2014)... August 28, 2014 Sterlitech is proud ... membranes to its stable of products . ... weight cut-offs and include membrane filters with surface charges. ... in customer demand for our membrane process testing equipment, ... of flat sheet membranes,” explains Sterlitech President Mark Spatz. ...
(Date:8/28/2014)... BELLINGHAM, Washington, USA (PRWEB) August 27, 2014 ... Colorado next month for SPIE Laser Damage 2014 ... on optical materials for high-power lasers will run 14-17 ... international society for optics and photonics . , The ... key for understanding laser damage to optical materials will ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3
... Therapeutics, Inc. (Nasdaq: TSRX ) announced today that ... present "Innovative Antibacterial Drugs by Design; The Trius Therapeutics Story" ... October 26, 2010 from 5:30-9:30 p.m. PT. ... . About Trius Therapeutics ...
... Pa., Oct. 22 Encorium Group, Inc. (Nasdaq: ... research organization (CRO) conducting studies in over 30 ... and biotechnology companies, today announced that, on October ... Listing Qualifications Panel (the "Panel") has determined to ...
... in German . Jena (21 October ... improving a fabrication process for Atomic Force Microscopy (AFM) probe ... surfaces so that even tiniest nano structures become visible. Knowledge ... of new materials and carrier systems for active substances. The ...
Cached Biology Technology:Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 2Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 3Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 4AFM tips from the microwave 2
... can perform many sophisticated DNA analysis and protein ... than just another sequence analysis product. Imagine having ... analyses to be performed each time you have ... sheets which specify exactly how your output will ...
... does for enzyme-/substrate-based blotting what intensifying screens do ... up to 10-fold (or one order of magnitude) ... Signal Enhancer membrane treatment is a simple, 15-minute ... current Western blotting protocol. The result is an ...
These stopping screens are for the biolistic PDS-1000 He and Hepta systems. Supplied as 500 screens....
...
Biology Products: