Navigation Links
Scientists discover how the brain ages
Date:9/11/2012

The ageing process has its roots deep within the cells and molecules that make up our bodies. Experts have previously identified the molecular pathway that react to cell damage and stems the cell's ability to divide, known as cell senescence.

However, in cells that do not have this ability to divide, such as neurons in the brain and elsewhere, little was understood of the ageing process. Now a team of scientists at Newcastle University, led by Professor Thomas von Zglinicki have shown that these cells follow the same pathway.

This challenges previous assumptions on cell senescence and opens new areas to explore in terms of treatments for conditions such as dementia, motor neuron disease or age-related hearing loss.

Newcastle University's Professor Thomas von Zglinicki who led the research said: "We want to continue our work looking at the pathways in human brains as this study provides us with a new concept as to how damage can spread from the first affected area to the whole brain."

Working with the University's special colony of aged mice, the scientists have discovered that ageing in neurons follows exactly the same rules as in senescing fibroblasts, the cells which divide in the skin to repair wounds.

DNA damage responses essentially re-program senescent fibroblasts to produce and secrete a host of dangerous substances including oxygen free radicals or reactive oxygen species (ROS) and pro-inflammatory signalling molecules. This makes senescent cells the 'rotten apple in a basket' that can damage and spoil the intact cells in their neighbourhood. However, so far it was always thought that ageing in cells that can't divide - post-mitotic, non-proliferating cells - like neurons would follow a completely different pathway.

Now, this research explains that in fact ageing in neurons follows exactly the same rules as in senescing fibroblasts.

Professor von Zglinicki, professor of Cellular Geront
'/>"/>

Contact: Karen Bidewell
press.office@ncl.ac.uk
44-019-122-26972
Newcastle University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... burning in eastern New South Wales, Australia when NASA,s ... 03:35 UTC on July 11 (12:35 p.m. local time/11:35 ... eastern New South Wales (NSW), the Moderate Resolution Imaging ... the region and spotted smoke (light brown) from various ... are outlined in red. , The New South Wales, ...
(Date:7/11/2014)... USC Stem Cell scientists have set a "mouse TRAP" ... described by a recent study published in the ... line uses a technique called TRAP to extract cellular ... , Invented by scientists at the Rockefeller Institute for ... tag to the protein-making machinery, or ribosomes, of the ...
(Date:7/11/2014)... from the Max Planck Institute for Medical Research in ... understanding photosynthesis, the process by which the Earth first ... and which is therefore crucial for all higher forms ... the first direct visualization of a crucial event in ... specific protein complex, photosystem II, splits water into hydrogen ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2
... of earth scientists report movement of warmed sea water through ... is greater than that off midocean volcanic ridges. The finding ... once considered barren. With about 71 percent of the ... under the sea, its geology, and the life it supports. ...
... German . Scientists at the Max ... have decoded the genome of the Pristionchus pacificus nematode, ... their work, which has been published in the latest ... Professor Ralf J. Sommer,s department in Tbingen have shown ...
... UC Davis researchers have defined a cellular process ... found an important starting point for identifying and ... rheumatoid arthritis, cardiovascular disease and some cancers. ... sPLA2-IIA binds to two integrins labeled alpha-V-beta-3 and ...
Cached Biology News:Ocean floor geysers warm flowing sea water 2Insight into the evolution of parasitism 2Insight into the evolution of parasitism 3UC Davis researchers discover new drug target for inflammatory disease 2
(Date:7/10/2014)... the basis of psychiatric disorders has been extremely challenging ... risk but are insufficient to cause disease. Now investigators ... Press journal Cell Stem Cell describe a ... risks interact with other risk factors or environmental exposures ... research pinpoints a genetic variant that may predispose individuals ...
(Date:7/10/2014)... RICHLAND, Wash. The lithium-ion batteries that power our ... run longer on a single charge with the help ... the porous material to replace the graphite traditionally used ... more than 10 times the energy storage capacity of ... lithium-ion battery electrode was published today in Nature ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
(Date:7/10/2014)... new alliance will see the two universities and NPL ... with business and industry and their complementary academic strengths., ... help to shape the scientific priorities of the UK. ... up to 300 high-calibre PhD students, will provide a ... NPL, the potential of the Laboratory will be grown ...
Breaking Biology Technology:New strategy could uncover genes at the root of psychiatric illnesses 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3
... DRRX ) announced today that James E. ... NewsMakers in the Biotech Industry Investment,Conference to be ... 2007 at 11:30 a.m.,Eastern Time. (Logo: ... the presentation will be available by accessing,DURECT,s homepage ...
... Text provides cardiologists with an overview of cardiovascular genetics ... ... TORONTO, Aug. 29 /PRNewswire-FirstCall/ - GeneNews Limited (TSX: GEN),a ... and staging of virtually any disease or medical,condition, today announced ...
... Pharmaceuticals,Inc. (Amex: ANX ) a biopharmaceutical research ... for the treatment,of cancer and infectious diseases, announced ... is scheduled to present at the 2007,Thomas Weisel ... 1:30 p.m. Eastern Daylight Time. The conference takes ...
Cached Biology Technology:GeneNews' Chief Scientist Dr. C.C. Liew co-editor of new genomics reference book 2ADVENTRX Pharmaceuticals to Present at the 2007 Thomas Weisel Partners Healthcare Conference 2
... The GSTTag Monoclonal Antibody is ... high affinity to the 26 kDa ... . This purified antibody is suitable ... GSTTag sequence expressed in E. coli ...
... LNA microarray slides for microRNA expression ... incorporate Exiqons unique Locked Nucleic Acid (LNA) ... mismatch discrimination for short microRNA (miRNA) targets. ... 1 g total RNA (no need for ...
... many modifications to the original formulas in efforts ... play an important role in tissue,culture. A salt ... osmotic balance in the medium and to provide ... is as valuable today as when it was ...
Imject Freund's Complete Adjuvant (FCA)...
Biology Products: