Navigation Links
Scientists discover how neuroglobin protects against Alzheimer's
Date:8/2/2010

A team of scientists at the University of California, Davis and the University of Auckland has discovered that neuroglobin may protect against Alzheimer's disease by preventing brain neurons from dying in response to natural stress. The team published the results of their study in the April, 2010 issue of Apoptosis.

Scientists have learned that neuroglobin protects cells from stroke damage, amyloid toxicity and injury due to lack of oxygen. Neuroglobin occurs in various regions of the brain and at particularly high levels in brain cells called neurons. Scientists have associated low levels of neuroglobin in brain neurons with increased risk of Alzheimer's disease. Recent studies have hinted that neuroglobin protects cells by maintaining the function of mitochondria and regulating the concentration of important chemicals in the cell. However, the exact mechanisms by which neuroglobin protects cells from dying a natural death has, until now, remained unclear.

The lead author of the study, UC Davis biomedical engineering professor Subhadip Raychaudhuri, found that neuroglobin preserves the functioning of a cell's mitochondria by neutralizing a molecule necessary for the formation of a type of protein that triggers the cell's collapse. The scientists think that the fundamental role of neuroglobin found in neurons is to prevent accidental cell death from occurring due to stress associated with normal cell functioning. Cells may protect themselves from triggering the chain of events leading to cell death by expressing a high level of neuroglobin.

Mitochondria are tiny "capsules" within a cell that make most of the raw material the cell uses to produce its energy. Mitochondria also play important roles in communication within and between cells and important aspects of cell differentiation and growth. A cell dies quickly when its mitochondria stop functioning. Various kinds of stressors, such as lack of oxygen, low nutrient levels, increased calcium levels or presence of toxic substances can cause mitochondria to rupture and emit a molecule called cytochrome c. Cytochrome c binds with other molecules outside the mitochondria to form a protein called an apoptosome. The apoptosome helps build an enzyme that degrades and eventually collapses the cell. Neural cells can survive damage to the mitochondria if apoptosomes do not form.

For their study, the researchers developed predictions from computational modeling and validated them with biological experiments. They found that neuroglobin binds to cytochrome c and prevents it from forming an apoptosome. This finding could offer new approaches to the prevention and treatment of Alzheimer's disease. In Alzheimer's disease, a toxic type of protein accumulates in brain neurons and leads to mitochondrial rupture and cell death. The finding suggests that high neuroglobin levels may buffer neurons against the effect of this protein by preventing apoptosomes from forming.

"Our discovery could lead to treatment of any neurodegenerative processes related to natural cell death. That might include patients suffering from stroke, in addition to Alzheimer's," Prof. Raychaudhuri said.


'/>"/>

Contact: Holly Ober
hjober@ucdavis.edu
University of California - Davis - Health System
Source:Eurekalert

Related biology news :

1. Scientists target possible cause of 1 form of bowel disease
2. Ecological scientists assess the fundamentals of animal behavior
3. Scientists post lower speed limit for cell-signaling protein assembly
4. Scientists uncover global distribution of marine biodiversity
5. American Society for Biochemistry and Molecular Biology honors 11 outstanding scientists
6. In the neck of time: Scientists unravel another key evolutionary trait
7. Engineered coral pigment helps scientists to observe protein movement
8. Scientists reprogram mouse fat cells into clinically useful stem cells
9. Scientists test Moreton Bay as coral lifeboat
10. Scientists discover how deadly fungal microbes enter host cells
11. Getting young scientists into the science teacher pipeline
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017  Socionext Inc., a ... prototype of a media edge server, the M820, which features the ... face recognition software provided by Tera Probe, Inc., will be showcased ... and at the NAB show at the Las Vegas ... ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... AMRI, a ... biotechnology industries to improve patient outcomes and quality of life, will now be ... are being attributed to new regulatory requirements for all new drug products, including ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... today it will be hosting a Webinar titled, “Pathology is going digital. Is ... , on digital pathology adoption best practices and how Proscia improves lab economics ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the main ... people each year. Especially those living in larger cities are affected by air pollution ... of the most pollution-affected countries globally - decided to take action. , “I knew ...
Breaking Biology Technology: