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Scientists discover how deadly fungus protects itself
Date:2/3/2009

Using a technique called dynamic light scattering, Dr. Frases and her colleagues found that the capsule grows by linking more and more saccharides together at the outer edge of the capsule, forming giant molecules pointing in an outward, or axial, direction.

The findings point to potential new targets for drug intervention and reveal a new area of investigation into basic polysaccharide biology. Polysaccharides are poorly understood, partly because of the difficulty of working with them. "Also, scientists have tended to view polysaccharides as boring molecules that simply grow to a specified length," says Dr. Casadevall.

"But this study raises huge questions about polysaccharides," he adds. "For example, how does the organism assemble these molecules, and how does it know how to make molecules that are roughly the same length? We don't know. There appears to be a whole dimension of cellular machinery that we never knew existed."


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Contact: Michael Heller
mheller@aecom.yu.edu
718-430-4186
Albert Einstein College of Medicine
Source:Eurekalert  

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