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Scientists discover how deadly fungal microbes enter host cells
Date:7/23/2010

A research team led by scientists at the Virginia Bioinformatics Institute (VBI) at Virginia Tech has discovered a fundamental entry mechanism that allows dangerous fungal microbes to infect plants and cause disease. The discovery paves the way for the development of new intervention strategies to protect plant, and even some animal cells, from deadly fungal infections. The findings are published in the July 23 edition of the journal Cell.

The researchers have revealed how special disease-related proteins, known as effectors, blaze a trail into cells. Fungi and fungal-like microbes known as oomycetes produce effector molecules that penetrate cells and switch off the host's defense system. Once the host's immune system has been disabled, the fungus or oomycete swiftly follows up, breaking and entering the cell and unleashing disease.

The pathogens in question, which include the microbe that caused the Irish potato famine in the nineteenth century, cause billions of dollars of losses for commercial farmers worldwide in crops such as soybean. They are also responsible for potentially fatal infectious diseases in humans.

Said Brett Tyler, professor at VBI and the leader of the project, "Our breakthrough finding is that these dangerous disease-causing proteins must bind a specific lipid molecule found on the cell surface before they can enter the cell."

In a previous study, Tyler and other researchers had pinpointed specific regions of the effector proteins that are intimately involved in breaking and entry of the cell. The new study shows that these regions on the effector proteins bind the lipid phosphatidylinositol 3-phosphate and that this binding is essential for the proteins to enter the cells. Adds Tyler, "The nasty proteins enter by hitching a ride on a lipid raft, a region of the cell's outer membrane that can be internalized by the cell. The lipid acts as a bridge between the effector protein and the raft, and
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Contact: Barry Whyte
whyte@vbi.vt.edu
540-231-1767
Virginia Tech
Source:Eurekalert

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