Navigation Links
Scientists discover how deadly fungal microbes enter host cells
Date:7/23/2010

A research team led by scientists at the Virginia Bioinformatics Institute (VBI) at Virginia Tech has discovered a fundamental entry mechanism that allows dangerous fungal microbes to infect plants and cause disease. The discovery paves the way for the development of new intervention strategies to protect plant, and even some animal cells, from deadly fungal infections. The findings are published in the July 23 edition of the journal Cell.

The researchers have revealed how special disease-related proteins, known as effectors, blaze a trail into cells. Fungi and fungal-like microbes known as oomycetes produce effector molecules that penetrate cells and switch off the host's defense system. Once the host's immune system has been disabled, the fungus or oomycete swiftly follows up, breaking and entering the cell and unleashing disease.

The pathogens in question, which include the microbe that caused the Irish potato famine in the nineteenth century, cause billions of dollars of losses for commercial farmers worldwide in crops such as soybean. They are also responsible for potentially fatal infectious diseases in humans.

Said Brett Tyler, professor at VBI and the leader of the project, "Our breakthrough finding is that these dangerous disease-causing proteins must bind a specific lipid molecule found on the cell surface before they can enter the cell."

In a previous study, Tyler and other researchers had pinpointed specific regions of the effector proteins that are intimately involved in breaking and entry of the cell. The new study shows that these regions on the effector proteins bind the lipid phosphatidylinositol 3-phosphate and that this binding is essential for the proteins to enter the cells. Adds Tyler, "The nasty proteins enter by hitching a ride on a lipid raft, a region of the cell's outer membrane that can be internalized by the cell. The lipid acts as a bridge between the effector protein and the raft, and
'/>"/>

Contact: Barry Whyte
whyte@vbi.vt.edu
540-231-1767
Virginia Tech
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... that transplantation of mesenchymal stem cells can stimulate neurogenesis ... of Alzheimer,s disease (AD) and improve tissue and function ... are reported on the therapeutic effect of adipose-derived stem ... the effect on oxidative injury and neurogenesis in the ... team, School of Life Sciences, Tsinghua University, China transplanted ...
(Date:7/11/2014)... receptor type 1 can inhibit voltage-gated calcium ... neurotransmitter release. However, some scholars demonstrated that ... Ca2+ influx and increase neurotransmitter release. Dr. ... Affiliated to Tongji Medical College, Huazhong University ... cell voltage-clamp and calcium imaging in cultured ...
(Date:7/11/2014)... Rio de Janeiro, Brazil- In the brains of ... mechanism that allows an electric or chemical signal ... another. Chemical synapses, which are the most abundant ... inhibitory. Synapse formation is crucial for learning, memory, ... and inhibitory synapses critical for brain function. ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2
... This press release is available in ... get a whole lot safer for consumers, thanks to Concordia ... foreign substances in dairy and other products. "Even though ... excessive antibiotics in cows, until now there were no methods ...
... release of massive amounts of carbon from methane hydrate ... been linked to the greatest change in global climate ... years earlier. New calculations by researchers at Rice University ... Nobody knows for sure what started the incident, but ...
... in the headlines around the world, this week,s edition of ... a 3-part cover story on the jobs situation for chemists ... manufactured goods, with the chemical industry in the United States ... weekly newsmagazine of the American Chemical Society, the world,s largest ...
Cached Biology News:Methane may be answer to 56-million-year question 2Methane may be answer to 56-million-year question 3
(Date:7/10/2014)... Understanding the basis of psychiatric disorders has been extremely ... increase risk but are insufficient to cause disease. Now ... Cell Press journal Cell Stem Cell describe ... genetic risks interact with other risk factors or environmental ... Their research pinpoints a genetic variant that may predispose ...
(Date:7/10/2014)... lithium-ion batteries that power our laptops and electric vehicles ... single charge with the help of a sponge-like silicon ... replace the graphite traditionally used in one of the ... the energy storage capacity of graphite. A paper describing ... published today in Nature Communications . , "Silicon ...
(Date:7/10/2014)... theatergoers have shelled out for crude 3-D glasses, ... viewing experience. These basic devices, used to trick ... may soon be rendered obsolete with the introduction ... University researchers. , TAU doctoral students Yuval Yifat, ... efficient holography based on nanoantennas that could be ...
(Date:7/10/2014)... and NPL collaborate to bring together their track record ... academic strengths., Working with BIS and NPL the successful ... the UK. The establishment of a Graduate Institute, which ... provide a pipeline of skilled researchers. Working with the ... be grown through the creation of a series of ...
Breaking Biology Technology:New strategy could uncover genes at the root of psychiatric illnesses 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3
... among the proposals introduced as part of the Invest Wisconsin ... State Sen. Ted Kanavas , R-Brookfield. , ,The legislative ... and other proposals to stimulate investment, seeks to change the ... Under the measure, all income tax payers would see a ...
... Executive Club of Chicago's annual forecast for this year, I ... look at the foreclosures on houses. You would think that by ... start to be more financially secure, but it does not look ... the tech sector is still spotty with stocks like Motorola ...
... Madison, Wis. - In a move that could bring ... of Madison will open an office in Ann Arbor, Mich. ... Madison venture capital firm, which recently moved into a larger ... Park , was one of three venture firms selected to ...
Cached Biology Technology:Kanavas outlines new Invest Wisconsin agenda 2Kanavas outlines new Invest Wisconsin agenda 3Real pulse of the economy? Check real estate foreclosures 2Real pulse of the economy? Check real estate foreclosures 3Real pulse of the economy? Check real estate foreclosures 4Real pulse of the economy? Check real estate foreclosures 5Venture Investors to open Michigan office 2
... is essential for hunting and analyzing ... such as EST sequencing projects, microarrays, ... kit is developed for normalization of ... intended for directional cloning. While most ...
... The Luminex 100 Instrument System ... multi-analyte assays using Upstate's Beadlyte reagents. ... the Dell computer with software version ... Sheath Delivery System. Upstate offers $2000 ...
Polyclonal Antibody to HADHB...
normal human fibroblasts Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Biology Products: