Navigation Links
Scientists discover how best to excite brain cells
Date:7/8/2011

ANN ARBOR, Mich.---Oh, the challenges of being a neuron, responsible for essential things like muscle contraction, gland secretion and sensitivity to touch, sound and light, yet constantly bombarded with signals from here, there and everywhere.

How on earth are busy nerve cells supposed to pick out and respond to relevant signals amidst all that information overload?

Somehow neurons do manage to accomplish the daunting task, and they do it with more finesse than anyone ever realized, new research by University of Michigan mathematician Daniel Forger and coauthors demonstrates. Their findings---which not only add to basic knowledge about how neurons work, but also suggest ways of better designing the brain implants used to treat diseases such as Parkinson's disease---were published July 7 in the online, open-access journal PLoS Computational Biology.

Forger and coauthors David Paydarfar at the University of Massachusetts Medical School and John Clay at the National Institute of Neurological Disorders and Stroke studied neuronal excitation using mathematical models and experiments with that most famous of neuroscience study subjects, the squid giant axon---a long arm of a nerve cell that controls part of the water jet propulsion system in squid.

Among the key findings: Neurons are quite adept at their job. "They can pick out a signal from hundreds of other, similar signals," said Forger, an associate professor of mathematics in the College of Literature, Science and the Arts and a research assistant professor of computational medicine and bioinformatics at the U-M Medical School.

Neurons discriminate among signals based on the signals' "shape," (how a signal changes over time), and Forger and coauthors found that, contrary to prior belief, a neuron's preference depends on context. Neurons are often compared to transistors on a computer, which search for and respond to one specific pattern, but it turns out that
'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... struggle to deal with ever-growing piles of electronic waste ... just how much there is and where it really ... Science & Technology , their study found that nearly ... into just seven developing countries with major potential ... Knut Breivik and colleagues note that the export from ...
(Date:7/23/2014)... HOLE, MA -- What do mollusks, starfish, and ... marine habitat, they are all calcifiersorganisms that use ... skeletons and shells for stability and protection. , ... , published by the Marine Biological Laboratory, addresses ... composition changes worldwide. , As atmospheric carbon dioxide ...
(Date:7/23/2014)... getting tangled and forming knots. Scientists study these knots ... them (e.g. useful for gene sequencing techniques). Cristian Micheletti, ... in Trieste and his team have been carrying out ... dynamics. In their latest paper, just published in the ... Di Stefano, first author and PhD student at SISSA, ...
Breaking Biology News(10 mins):Calcification in changing oceans explored in special issue of The Biological Bulletin 2
... the oocysts from the Cryptosporidium genus and cysts ... greatest public health problems in water supply, because these parasites ... Hermida, a scientist at the Galician Institute for Food Quality ... A team led by this researcher took 232 water samples ...
... NextCAT Inc., a Detroit-based company, announced that it has ... developed at the National Biofuels Energy Lab at Wayne ... NextCAT to commercialize a class of catalysts that enable ... waste vegetable oil, animal fats and residual corn oil, ...
... named Brontomerus mcintoshi , or "thunder-thighs" after its enormously powerful ... is described in a paper recently published in the journal ... the U.K. and the U.S. A member of the ... Brachiosaurus , Brontomerus may have used its powerful ...
Cached Biology News:Parasitic protozoons survive waste water and drinking water treatment plants in Galicia 2NextCAT secures license agreement for advanced biofuel technology from Wayne State 2New 'thunder-thighs' dinosaur discovered 2New 'thunder-thighs' dinosaur discovered 3
(Date:7/23/2014)... and Russian Quantum Center at Skolkovo) and Mario ... the Institute of Physics in Bratislava, Slovakia) have ... particles passing through an amplifier and, conversely, when ... provided in an article published in the journal ... Quantum entangled particles are considered to be the ...
(Date:7/23/2014)... ANGELES , July 23, 2014 /PRNewswire-iReach/ -- Think ... cognitive performance for the long term. They are the ... edge of sustained energy as an alternative to the ... Think Drinks on Indiegogo on July 29, 2014, with ... 30-day campaign. Photo - http://photos.prnewswire.com/prnh/20140723/129697 ...
(Date:7/23/2014)... Columbia, MD (PRWEB) July 23, 2014 ... Station, an LC/MS amino acid analysis system developed ... analysis, the UF-Amino Station can analyze 38 amino ... , The UF-Amino Station achieves high-speed analysis utilizing ... spectrometer. The LCMS-2020 provides accurate analytical results even ...
(Date:7/23/2014)... 23, 2014  Having the right people at the ... accelerating business growth and achieving clinical and operational goals. ... Leadership Summit, July 20-22, 2014, in San ... executives and healthcare experts discussing how partnerships have positively ... President & Chief Executive Officer of Cape Regional Medical ...
Breaking Biology Technology:Scientists find way to maintain quantum entanglement in amplified signals 2Scientists find way to maintain quantum entanglement in amplified signals 3Scientists find way to maintain quantum entanglement in amplified signals 4truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2Shimadzu's New UF-Amino Station Provides High-Speed, Multi-Component Analysis of Amino Acids in Food & Beverage and Pharmaceutical Testing 2MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2
... pfuturbo DNA polymerase for robust, high-fidelity PCR,amplification ... Valerie,Hedden Connie Hansen Janice Cline Frances ... ,Stratagene , Stratagene announces the release of pfuturbo DNA ... for high-fidelity,PCR. PfuTurbo DNA polymerase is a blend ...
... One-column protein purification and native eukaryotic amino ... Lu John Bauer ,Stratagene Cloning Systems, ... expression system features rapid and high-yield,production of ... cloning (LIC) for efficient and directional cloning ...
... Sensitive, and Rapid Detection of FLAG -Tagged Fusion Proteins ,,,,, ... Sensitive, and Rapid Detection of FLAG -Tagged,Fusion ... Hosfield Peter Pingerelli, Weiping Yang ,Stratagene , Stratagenes TagDetect ... , is an easy-to-use assay kit for detecting ...
Cached Biology Technology:Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 2Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 3Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 4Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 5Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 6Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 7Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 8Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 9Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 10Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase 11New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 2New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 3New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 4New Yeast Cloning System for Producing Proteins with Native Amino Acid,Sequences 5Simple, Sensitive, and Rapid Detection of FLAG -Tagged,Fusion Proteins 2Simple, Sensitive, and Rapid Detection of FLAG -Tagged,Fusion Proteins 3Simple, Sensitive, and Rapid Detection of FLAG -Tagged,Fusion Proteins 4
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV....
BD BioCoat Matrigel Matrix 35 mm Culture Dishes Coating : BD MatrigelTM Basement Membrane Matrix ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vo...
... General description: Compatible with AutoGen AutoGenesys, ... high volume automated colony picking systems This ... created to easily match Cornings product number. ... under the old Sigma-Aldrich number (D9314) or ...
... provides a positive selection for creating baculovirus ... in insect cells. The kit improves on ... by eliminating the time-consuming steps of plaque ... genome with a portion of the essential ...
Biology Products: