Navigation Links
Scientists discover gene module underlying atherosclerosis development
Date:12/4/2009

By measuring the total gene activity in organs relevant for coronary artery disease (CAD), scientists at the Swedish medical university Karolinska Institutet have identified a module of genes that is important for the recruitment of white blood cells into the atherosclerotic plaque. The findings, which are to be published in the open-access journal PLoS Genetics, suggest that targeting the migration of white blood cells in the development of atherosclerosis may help to reduce the risk for adverse clinical effects such as ischemia and myocardial infarction.

Atherosclerosis is the major cause of myocardial infarction and stroke, and is responsible for half of all deaths in Sweden and other Western countries. Complications of atherosclerosis are rapidly increasing as a major cause of death also in developing countries; the World Health Organisation has predicted that this will become the number one killer by 2010.

"It has been an exciting research project, which has gone on for nearly seven years, involving many different disciplines from thoracic surgeons to mathematicians", says team leader Dr. Johan Bjrkegren at Karolinska Institutet in Stockholm. "I believe that this kind of clinical study will follow in the aftermath of the large number of ongoing genome-wide association studies."

Rather than individual genes or individual DNA variants, the discovery encompasses a group of 128 functionally related genes in a 'module' or 'network', which explains their mutual interactions. The involvement of most of these genes in CAD has not previously been known, but it has been known that they are involved in endothelial function and angiogenesis.

Through the collaboration with Dr. Eric Schadt's team at Washington University, Seattle, the researchers were also able to take advantage of previously published genome-wide association studies (GWAS) of CAD to show that the gene module they have discovered is enriched for inherited risk of developing myocardial infarction.

"The GWAS are genetic epidemiology studies often involving tens of thousands of patients and controls, originally designed to link isolated DNA locus to the risk of developing complex common disorders, such as atherosclerosis", says Dr Bjrkegren. "These studies now need to be complemented with clinical studies where the patients also are screened for intermediate molecular phenotypes in disease-relevant organs. The computational capacities and expertise required to address simultaneously all molecular activities and their relative risk-enrichment are available, all that remains is to start recruiting this kind of cohorts."

The findings suggest that the severity of atherosclerosis depends on the rate of the migration of white blood cells from the blood into the atherosclerotic plaques. Although this pathway is already known to play a role in atherosclerosis, the Swedish findings suggest that it is the rate limiting step for disease progression. However, Dr Bjrkegren admits that the exact roles of all 128 genes in atherogenesis remain unexplained. Future studies will focus on understanding the details of how these genes actually contribute to atherosclerosis in cell cultures and animal model systems.


'/>"/>

Contact: Press Officer Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... Italy , May 23, 2017  Hunova, the first robotic gym ... trunk, has been officially launched in Genoa, Italy . ... Europe and the USA . The technology ... on the market by the IIT spin-off Movendo Technology thanks to a ... the Multimedia News Release, please click: ...
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... For the months of ... a Spotlight series on “Cell Therapy Regulation” for its regenerative medicine ... on the unique regulatory challenges of stem cell medical research. , Stem cell ...
(Date:6/22/2017)... , ... June 22, 2017 , ... Charm Sciences, Inc. ... The AMPH test was determined to be appropriate as a screening test at dairies ... on the Charm EZ system, and the Charm EZ Lite system. These systems are ...
(Date:6/20/2017)... 20, 2017  Kibow Biotech Inc., a pioneer in ... issuance of a new patent covering a unique method ... U.S. Patent and Trademark Office on May 23 rd ... Buzz of Bio award in 2014 in ... non-drug approaches to chronic disease. Renadyl™, the first and ...
(Date:6/19/2017)... ... June 19, 2017 , ... As Vice President, ... products including training, implementation, support, and client process and SOP development. , Mr. ... previously held leadership roles for service providers and top-tier pharmaceuticals, and as an ...
Breaking Biology Technology: