Navigation Links
Scientists discover ethnic differences in immune response to TB bacterium
Date:7/4/2013

rent amounts of inflammation. One might therefore expect that TB patients' immune responses would differ according to the strain of TB bacterium that they are infected with.

"However our study has shown, for the first time, that it is actually ethnic differences in the patient's genetic make-up that cause most of this variation in immune responses with little effect of the TB strain they are infected with."

By analysing blood samples taken from 85 of the original cohort after an eight-week period of intensive treatment, the researchers found that ethnic variation in immune responses became even more marked. A number of immunological biomarkers, which correlated with either fast or slow clearance of the TB bacteria, were identified and found to differ between Africans and Europeans/Asians.

Dr Anna Coussens, who measured immune responses in patient samples at NIMR, said: "These findings have important implications, both for the development of new diagnostic tests, which increasingly rely on analysing the immune response, and also for work to identify candidate biomarkers to measure response to anti-TB treatment. In the future, diagnostic tests and biomarkers will need to be validated in different ethnic populations."

A key factor in determining the ethnic variation identified in the study appears to be the patients' genetic type of vitamin D binding protein a molecule which binds vitamin D in the circulation.

Dr Martineau said: "There are different genetic types of this protein which vary in frequency between ethnic groups, adding to the growing evidence that vitamin D and the way it is carried in the blood is crucial in determining how a patient's immune system will respond to TB."

Further studies in other populations are now needed to validate the ethnic difference identified.

This work was funded by the British Lung Foundation and the Medical Research Council (MRC).

Dr John Moore-Gillon, Honorary Med
'/>"/>

Contact: Katrina Coutts
k.coutts@qmul.ac.uk
Queen Mary, University of London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists identify promising antiviral compounds
2. Harvard and USC scientists show how DHA resolves inflammation
3. Tiny nanocubes help scientists tell left from right
4. Scientists discover thriving colonies of microbes in ocean plastisphere
5. Scientists discover new details about rice blast, a deadly plant fungus
6. Research reveals low exposure of excellent work by female scientists
7. Scientists use DNA from a museum specimen to study rarely observed type of killer whale
8. Hundreds of insect scientists migrating to Rapid City this week
9. Scientists identify potential drug target for treatment-resistant anemias
10. Carnegie Mellon neuroscientists discover new phase of synaptic development
11. OHSU scientists advance understanding of brain receptor; may help fight neurological disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... PALM BEACH GARDENS, Fla. , June ... of multi-factor identity management and authentication solutions, today ... Altus strong, multi-factor authentication solution.  The ... ease of use of the DigitalPersona Altus ... and biometric reader compatibility. In ...
(Date:6/17/2015)... , Deutschland und GERMANTOWN, Maryland , ... ®   Produktlinie mit DNA-Tests verbessert ... N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) ... neue STR-Testkits der Produktlinie Investigator ® ... den Markt eingeführt. Die neuen Kits zur Erstellung genetischer ...
(Date:6/17/2015)... , June 17, 2015  Crossmatch™, a leading ... that its U.are.U ® 4500 fingerprint readers ... Eateries, Inc., a San Jose, ... to increase security, improve accountability and reduce fraud ... instant, non-repudiable identity confirmation for employee sign in ...
Breaking Biology News(10 mins):Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3
... 2007) – A Virginia Commonwealth University Massey Cancer Center ... $1.3 million from the National Cancer Institute to improve ... as histone deacetylase inhibitors, in the treatment of leukemia ... Steven Grant, M.D., Massey,s associate director for translational research ...
... recent years, there has been growing interest in the ... into soils via manure application is of environmental relevance. ... of the journal CLEAN, Kreuzig and co-workers now focused ... valuable data to the so far available data set ...
... , Research on hydrogen-fueled cars may be one ... hydride discovered by scientists at the ESRF. The material, lithium ... weight percents of hydrogen, which makes it attractive for use ... hydrogen at quite high temperatures (above 300C). The team has ...
Cached Biology News:NCI renewal grant to develop new cancer therapies 2New insights into the fate of antiparasitics in manure and manured soils 2New form of compound stimulates research on hydrogen storage 2New form of compound stimulates research on hydrogen storage 3
(Date:7/1/2015)... Costa Mesa, CA (PRWEB) , ... July 01, 2015 , ... ... and traumatic brain injury (TBI) using single photon emission computed tomography (SPECT) ... Columbia. The study, which examined over 20,000 brain scans and is believed to ...
(Date:7/1/2015)... and BANGALORE, India , July 1, ... company that uses next generation sequencing technology to empower ... A. Storrer as chief executive officer. In his ... be responsible for all strategy, business expansion and worldwide ... has served as Strand,s chairman and CEO since its ...
(Date:7/1/2015)... ... July 01, 2015 , ... A newly launched business plan contest will ... barriers to innovation in life sciences R&D. The Pistoia Alliance President’s Startup Challenge 2015 ... US$15,000 and a period of expert mentorship from a senior industry figure drawn from ...
(Date:7/1/2015)... July 1, 2015  UCB, a multinational biopharmaceutical ... global leader in designing, transforming, and running intelligent ... in recognition of their close collaboration in driving ... global business services (GBS) finance organization. ... clients that work together effectively to embrace the ...
Breaking Biology Technology:Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5
... MONMOUTH JUNCTION, N.J., Aug. 11, 2011 Insmed Incorporated ... Timothy Whitten, President and CEO of Insmed, will be ... Life Sciences Management Access Conference on Tuesday, August 16, ... A live audio webcast will be available on ...
... International (CDI) announced today the recent launch of its ... researchers, understanding of induced pluripotent stem cells (iPSCs), the ... and applications of this new in vitro cellular model ... "The off-the-shelf availability of high quality human cell ...
... is pioneering new compound management discussion platform with launch of the ... Online event, which will take an innovative form of 11 ... st   of October 2011. ... agenda for many organisations and this was recently recognised by Dr. ...
Cached Biology Technology:Insmed to Present at 2011 Wedbush Securities Life Sciences Management Access Conference 2Cellular Dynamics Launches Innovative Research Grant Program 2Compound Management and Integrity Goes Online 2Compound Management and Integrity Goes Online 3
... developed for use with immunohistochemical (IHC) ... background staining due to endogenous peroxidase. ... with hydrogen peroxide. This reagent ... additional novel components to further quench ...
Phospho-Btk (Tyr223) Antibody...
Rad51B...
p27 rabbit polyclonal antibody...
Biology Products: