Navigation Links
Scientists discover ethnic differences in immune response to TB bacterium
Date:7/4/2013

The immune response to the bacterium that causes tuberculosis (TB) varies between patients of different ethnic origin, raising important implications for the development of tests to diagnose and monitor treatment for the disease, according to new research published today in the journal PLOS Pathogens.

The study, led by researchers at Queen Mary, University of London, in collaboration with the Medical Research Council's National Institute for Medical Research (NIMR),analysed the immune response of 128 newly-diagnosed TB patients in London who were divided by ethnicity into those of African (45), European (27), Asian (55) or mixed European/Asian (1) ancestry.

TB is an infection caused by the TB bacterium Mycobacterium tuberculosis. It commonly affects the lungs. While it grew rare in the UK due to BCG vaccination, improvements in living standards and the introduction of effective antibiotic treatment, it has been on the increase since the late 1980s. TB also remains a major global health problem, responsible for nearly nine million new cases and 1.4million deaths in 2011.

By analysing the levels of various inflammatory markers in blood samples taken before treatment, the scientists showed that immune responses of Asians and Europeans were similar to each other, but different from those of Africans. This difference was caused by ethnic variation in the patients' genetic make-up and was not related to the strain of TB bacterium that the patients were infected with.

Dr Adrian Martineau, Reader in Respiratory Infection and Immunity at the Blizard Institute, part of Queen Mary, who led the research, said: "The TB bacterium has co-evolved with humans following migration to Europe and Asia some 70,000 years ago, and different strains of the TB bacterium disproportionately infect particular ethnic groups. Experiments with white blood cells cultured in the lab have shown that different strains of the TB bacterium elicit diffe
'/>"/>

Contact: Katrina Coutts
k.coutts@qmul.ac.uk
Queen Mary, University of London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists identify promising antiviral compounds
2. Harvard and USC scientists show how DHA resolves inflammation
3. Tiny nanocubes help scientists tell left from right
4. Scientists discover thriving colonies of microbes in ocean plastisphere
5. Scientists discover new details about rice blast, a deadly plant fungus
6. Research reveals low exposure of excellent work by female scientists
7. Scientists use DNA from a museum specimen to study rarely observed type of killer whale
8. Hundreds of insect scientists migrating to Rapid City this week
9. Scientists identify potential drug target for treatment-resistant anemias
10. Carnegie Mellon neuroscientists discover new phase of synaptic development
11. OHSU scientists advance understanding of brain receptor; may help fight neurological disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... 2015 Transparency Market Research has ... - Global Industry Analysis, Size, Share, Growth, Trends and ... recognition is forecast to reach US$ 2,671.8 Mn by ... surveillance systems by civil and government agencies. This is ... terrorist activities across the globe that would elevate the ...
(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
(Date:8/3/2015)... SAN JOSE, Calif. , Aug. 3, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that members ... investment community at the Pacific Crest Global Technology Leadership ... Mountain Time. The conference will be held at the ... The presentation may include forward-looking information. ...
Breaking Biology News(10 mins):Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2
... season coming up soon, egg consumption is expected to rise temporarily. ... of eggs they can? "Parasites such as fowl mites that ... more," says Bradley A. Mullens , a professor of ... to boost egg production is to rid the hens of these ...
... bacteria in the genus Rickettsia spread through a population of ... pest of global importance. Infected insects lay more eggs, develop ... to their uninfected peers. The discoveries were made by ... in the April 8 issue of the journal Science ...
... known to favor the evolution of a variety of traits, ... changes in metabolism and feeding behavior. Now researchers reporting online ... Press publication, have added sleeplessness to that list. "Cave-adapted ... Borowsky of New York University. "In some ways, their sleep ...
Cached Biology News:UC Riverside entomologists propose pesticide-free method to increase egg production 2Instant evolution in whiteflies: Just add bacteria 2Instant evolution in whiteflies: Just add bacteria 3Instant evolution in whiteflies: Just add bacteria 4Through evolution, cavefish have lost sleep 2
(Date:8/27/2015)... 27, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... ended June 30, 2015. Biorem,s complete second quarter financial statements and ... FINANCIAL HIGHLIGHTS: in ,000,s except earnings per shareThree-months ended , Six -months ... , 2015 , 2014 Revenue , 4,709 ... 4,433 Gross profit , 1,656 , 56 ...
(Date:8/27/2015)... , Aug. 27, 2015 In response ... FedEx, UPS and The US Postal Service to ... classified as ,select agents, by the CDC, Marken ... handling these sensitive shipments. Marken uses ... regulations, trained and certified personnel to ensure the ...
(Date:8/26/2015)... ... August 26, 2015 , ... ... its investment in the development and manufacture of highly valued cardiac markers used ... scientific team's extensive expertise with protein chemistry has led to the development and ...
(Date:8/26/2015)... HONG KONG , Aug. 26, 2015 ... "Company"), China,s leading provider of ... and stem cell storage services, today announced that the ... Holdings Limited ("MO2"), an entity wholly owned by Mr. ... the Company, has acquired the outstanding shares (the "Shares") ...
Breaking Biology Technology:BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3
... Dynamic, thorough, and robustly qualified are a few ... Consultant, Philippe Vitat, who brings with him expertise and an ... as a certified medical writer and editor since 2001 and ... medical education by the International Biographical Center in Cambridge, ...
... ... The Chinese Biopharmaceutical Association-USA (CBA) announced today that it ... Maryland, US. ,The event will highlight current breakthroughs, new ... develop a platform for communication and collaboration among biopharmaceutical companies, ...
... an interview with a researcher, please contact the Communications and ... tip. For more information on ORNL and its research and ... If you have a general media-related question or comment, you ... MILITARY - Intelligent intelligence . . . ...
Cached Biology Technology:Highly Regarded Medical Writer Joins Avant Healthcare Marketing Team 2Chinese Biopharmaceutical Association Holds 15th Annual Conference in Rockville, MD, June 12 - 13 2Chinese Biopharmaceutical Association Holds 15th Annual Conference in Rockville, MD, June 12 - 13 3Story tips from the Department of Energy's Oak Ridge National Laboratory May 2010 2Story tips from the Department of Energy's Oak Ridge National Laboratory May 2010 3
...
... submicron range are part of your production ... of particle size is important to you. ... detect the component populations in your sample ... Analyzer uses Photon Correlation Spectroscopy (PCS) , ...
...
... offers a dedicated system for SFC and ... series of HPLC instrumentation. JASCO has recently ... capability of the system: ,- The PU-1580-CO2 ... extraction procedures using carbon dioxide as the ...
Biology Products: