TORONTO, September 24, 2013 For the first time, scientists at Toronto Rehab have found that in people with chronic moderate-severe traumatic brain injury (TBI), atrophy (shrinkage) in the brain may be countered by participating in environmental enrichment increased physical, social and cognitive stimulation.
The paper, entitled "Environmental enrichment may protect against hippocampal atrophy in the chronic stages of traumatic brain injury," was published today in the open-access journal Frontiers in Human Neuroscience. The principal investigator of this study is Dr. Robin Green, senior scientist and clinical neuropsychologist, Toronto Rehab, UHN and Canada Research Chair in Traumatic Brain Injury.
This research study builds on Dr. Green's recent findings that suggest moderate-severe TBI may be a progressive neurological disorder a whole new way of perceiving the condition. Only a handful of labs in the word are investigating this topic.
"The conventional wisdom about moderate-serious TBI is that there is neurological damage to the brain that manifests over the course of hours and days. Then, after a period of recovery months to years a plateau is reached where there are no further changes to the brain," said Dr. Green.
Dr. Green's recent findings show something else is going on. Using magnetic resonance imaging (MRI), Dr. Green and colleagues observed ongoing damage or atrophy in the brains of many people with moderate-severe TBI.
Exactly what's causing this -- and whether it eventually stabilizes -- is unclear. At one level, inflammation, delayed apoptosis (programmed cell death) and excessive protein accumulation may play a role. What seems clearer is that the damaged areas affect healthy cells.
"What we believe is going on," said Dr. Green, "is that after a serious brain injury, damaged tissue disconnects the healthy areas of the brain. Those healthy areas are under stimulated and, over time,
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