Navigation Links
Scientists discover endogenous dendritic cell-derived interleukin-27 promotes tumor growth
Date:5/1/2014

In a new report published in the Journal of Leukocyte Biology, scientists lay the groundwork for the development of novel tumor therapies that may help rid the body of cancer by inhibiting the recruitment of a specific suppressive immune cell type called "regulatory T-cells." The approach described in the report shows that an immune molecule, called interleukin-27, promotes the recruitment of regulatory T-cells. This suggests that by stopping IL-27's immunosuppressive function, cancer therapies can more effectively activate other T-cells to attack and destroy cancer tumors.

"Our study not only provides a new insight into the effects of interleukin-27 in regulatory T-cell biology, but also greatly improves our understanding of the physiological functions of interleukin-27, especially in tumor immunology," said Siyuan Xia, a researcher involved in the work from the State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. "We hope our study could shed new light on developing novel interventional therapies by targeting regulatory T-cells in cancer patients."

Scientists made this discovery by using mice deficient in a specific subunit of interleukin-27 called p28. They compared the tumor infiltrating lymphocytes between interleukin-27 p28 deficient mice and normal mice, and through their experiments, found a significant decrease of regulatory T cells, and other key immune mediators in the absence of interleukin-27 p28.

"Suppressive and regulatory pathways in the immune system are incredibly important for normal health and preventing autoimmunity," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "However, these pathways also get exploited by cancer to prevent immune responses leading to cancer progression. The current studies point to an important regulatory network centered on interleukin-27 that could be targeted to improve immunity to cancer in humans."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/17/2019)... ... July 15, 2019 , ... RCH ... Life Sciences and Healthcare companies, announces the availability of new specialty advisory practice, ... direction to start-up and emerging bio-pharma companies interested in achieving specific outcomes related ...
(Date:7/9/2019)... ... July 09, 2019 , ... Murrieta Genomics, a launch pad ... The founder and CEO of Tx Genetic, Helen Harrison, has spent several years ... epithelial connective tissue disorders. , “We are pleased and excited to join the ...
(Date:6/25/2019)... ... , ... ActX has launched a medical genetic interpretation ... can get access to professionally reviewed genetic screening similar to what a physician ... + Ancestry customers., With the ActX + 23andMe service, both 23andMe customers and ...
Breaking Biology News(10 mins):
(Date:5/8/2019)... ... , ... Standing at 16.2 hands, Atlas is on the large side for a Quarter Horse. ... racing, among other activities. When loping around a corner in late 2017, Atlas tripped ... horse to only being able to walk. Fortunately Atlas’ owner, Kelly, sought the opinion ...
(Date:5/4/2019)... , ... May 03, 2019 , ... ... the President of the Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes ... in Brasília (DF). Urandir detailed the results of some research carried out by ...
(Date:5/2/2019)... (PRWEB) , ... April 30, ... ... the International Organization for Standardization ISO 9001:2015 standard, REPROCELL USA Inc. has ... customer requirements. In addition, REPROCELL USA Inc. aims to enhance customer satisfaction ...
(Date:5/2/2019)... ... May 02, 2019 , ... Stay on top of current ... and food industries. Access to all webinars is free, so be sure to register ... field! , Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL TRIALS ...
Breaking Biology Technology: