Navigation Links
Scientists discover bacteria that can cause bone infections
Date:10/17/2008

Scientists have discovered that a bone infection is caused by a newly described species of bacteria that is related to the tuberculosis pathogen. The discovery may help improve the diagnosis and treatment of similar infections, according to an article published in the October issue of the International Journal of Systematic and Evolutionary Microbiology.

Some rare genetic diseases can make patients susceptible to infections with Mycobacterium species, the bacteria that amongst other diseases, cause tuberculosis and leprosy. These patients often suffer from recurring mycobacterial infections throughout their whole lives. Because of this, researchers are trying to identify unusual species that cause disease in order to improve treatment strategies.

"We isolated an unknown species of bacteria from a 7 year old child who has a genetic immune defect," said Dr Didi Bang from Statens Serum Institut in Copenhagen, Denmark. "The infection had caused bone lesions and this is where we found the newly described bacteria."

Mycobacterial infections can be very difficult to treat. The bacteria have unique cell walls that protect them from several antibiotics. As well as being resistant to treatment, they can also survive attack with acids, alkalis and detergents. Most mycobacterial infections can be treated with antibiotics such as clarithromycin and rifamycins, but some species are becoming resistant to these antibiotics, so new drugs for treatments must be developed.

"Initial tests suggested we had found a Mycobacterium. By sequencing some of the bacterium's genes we showed that we had discovered an undescribed species," said Dr Bang. "We called the bacterium Mycobacterium arosiense. The name comes from Arosia, the Latin name of the city of Aarhus in Denmark, which is where the bacterium was first found. We showed the position of the new bacterium on the Mycobacterium family tree by sequencing genes and comparing them to related bacteria."

The new pathogen is closely related to Mycobacterium intracellulare and Mycobacterium avium, which cause a lung disease similar to tuberculosis in people, especially those with weak immune systems such as HIV patients that are immunologically suppressed. It is rod-shaped and grows slowly.

"Mycobacterium arosiense can be killed by several antibiotics in the lab, including clarithromycin and rifamycins. However, resistance to fluoroquinolones and isoniazid was observed," said Dr Bang. "Little knowledge is available on performing resistance tests on mycobacteria other than tuberculosis."

"We hope that this discovery will help doctors to diagnose similar diseases in the future and that further investigation may improve the treatment of people with similar infections."


'/>"/>

Contact: Lucy Goodchild
press@sgm.ac.uk
44-011-898-81843
Society for General Microbiology
Source:Eurekalert

Related biology news :

1. Scientists propose the creation of a new type of seed bank
2. EMBO honors 59 leading life scientists
3. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
4. Extreme nature helps scientists design nano materials
5. Forsyth scientists trigger cancer-like response from embryonic stem cells
6. Scientists trace molecular origin of proportional development
7. Sensitive nanowire disease detectors made by Yale scientists
8. Scent on demand: Hebrew University scientists enhance the scent of flowers
9. MSU scientists find new gene that helps plants beat the heat
10. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
11. Brookhaven scientists take off for southeastern Pacific climate study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:3/30/2017)... 30, 2017  On April 6-7, 2017, Sequencing.com will ... hackathon at Microsoft,s headquarters in ... focus on developing health and wellness apps that provide ... the Genome is the first hackathon for personal ... largest companies in the genomics, tech and health industries ...
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
Breaking Biology News(10 mins):
(Date:8/23/2017)... ... August 23, 2017 , ... Heidelberg ... for advanced VPG+ 800 Volume Pattern Generators from two major Asian based phtotomask ... for production of advanced photomasks as well as a solution for mid volume ...
(Date:8/22/2017)... ... August 22, 2017 , ... KBioBox is ... KBioBox technology, the extended GUIDE-Seq ananlysis. KBioBox has adapted their core technology and ... provide scientists with easy to understand reports, extended indel analysis, and translocation analysis. ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... utilizing its extensive experience with Health Economics and Outcomes Research (HEOR) and ‘big ... data. In 2014, US healthcare spending exceeded $3.0 trillion with nearly 1/3 spent ...
(Date:8/17/2017)... (PRWEB) , ... August 17, 2017 , ... ... the stock market news outlet had provided a research update on Aytu Bioscience ... administered TRT product. , According to Soulstring, prescription rates for Natesto® have more ...
Breaking Biology Technology: