Navigation Links
Scientists discover ancient viral invasion that shaped human genome
Date:6/7/2010

Scientists at the Genome Institute of Singapore (GIS), a biomedical research institute of the Agency for Science, Technology and Research (A*STAR), and their colleagues from the National University of Singapore, Nanyang Technological University, Duke-NUS Graduate Medical School and Princeton University have recently discovered that viruses that 'invaded' the human genome millions of years ago have changed the way genes get turned on and off in human embryonic stem (ES) cells.

The study provides definitive proof of a theory that was first proposed in the 1950s by Nobel Laureate in physiology and medicine, Barbara McClintock, who hypothesized that transposable elements, mobile pieces of the genetic material (DNA), such as viral sequences, could be "control elements" that affect gene regulation once inserted in the genome.

This finding is an important contribution to the advancement of stem cell research and to its potential for regenerative medicine. Led by GIS Senior Group Leader Dr Guillaume Bourque, the study was published in Nature Genetics on June 6, 2010.

Through the use of new sequencing technologies, the scientists studied the genomic locations of three regulatory proteins (OCT4, NANOG and CTCF) in human and mouse embryonic stem (ES) cells. Interestingly, while the scientists found a lot of similarities, they also found many differences in the methods and the types of genes that are being regulated in humans. In particular, it was discovered that specific types of viruses that inserted themselves in the human genomes millions of years ago have dramatically changed the gene regulatory network in human stem cells.

"This study is a computational and experimental tour de force. It provides undeniable evidence that some transposable elements, which are too often dismissed as merely junk DNA, are key components of a regulatory code underlying human development," said Dr Cedric Feschotte, Associate Professor of the U
'/>"/>

Contact: Winnie Lim
limcp2@gis.a-star.edu.sg
656-808-8013
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study of microRNA helps NIH scientists unlock secrets of immune cells
2. ARS scientists seek blight-resistant spuds
3. Scientists clarify origins of potato germplasm Neo-Tuberosum
4. Atmospheric scientists start monthlong air sampling campaign
5. Scripps research scientists determine structure of immune molecule that counteracts HIV strains
6. NYSCF awards fellowships to 8 innovative stem cell scientists
7. Scientists decipher structure of natures light switch
8. Scientists find genes associated with throat cancer through study of over 10,000 subjects
9. NIST scientists gain new core understanding of nanoparticles
10. Scientists conclude asteroid ended the age of dinosaurs
11. Scientists to study impact of gulf oil spill on marine food webs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... Life, is a non-traditional biophysics textbook and it describes ... a journey of discovery into biological systems and provides ... regulation. It is about how our genes make proteins ... billions of cells in an organism. It quantifies the ... which can be found on both large and small ...
(Date:10/15/2014)... to bacterial pneumonia in female mice to an enzyme ... are naturally more resistant to respiratory infections than males. ... increased resistance to bacterial pneumonia in female mice is ... They also show that this enzyme is ultimately activated ... , The team, lead by Professor Lester Kobzik at ...
(Date:10/15/2014)... 2014   Neurotechnology , a provider of ... of the VeriLook Surveillance 3.0 software development ... biometric face identification using live video streams from ... new version not only identifies faces in a ... while they are moving through the video frame. ...
Breaking Biology News(10 mins):New book about life as seen from physics 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3
... piece to the mounting body of evidence that suggests ... "passive ventilation" significantly increases survival rates, compared to the ... an online edition of Annals of Emergency Medicine, compared ... arrest outside a hospital setting and were resuscitated in ...
... University of Jerusalem have succeeded for the first time ... basic cellular mechanism that enables networks of neurons to ... research may lead to the upgrading of computer algorithms ... as to the development of innovative treatments for auditory ...
... August 11, 2009 Researchers at the Department of ... the effects of formal education on the symptoms of ... diminishes the impact of Alzheimer,s disease on cognition even ... The results are published in the current issue of ...
Cached Biology News:Cardiac arrest resuscitation: Passive oxygen flow better than assisted ventilation 2Hebrew U. researchers shed light on the brain mechanism responsible for processing of speech 2Formal education lessens the impact of Alzheimer's disease 2
(Date:10/18/2014)... The Asia-Pacific Liquid Crystal on Silicon (LCoS) display ... Asia-Pacific with analysis and forecast of revenue. This market ... expected to reach $380.0 million by 2018, at a ... through the TOC of the Asia-Pacific LCoS display market ... provided. This also provides a glimpse of the segmentation ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 According to ... Resource & Well Type - Global Trends & Forecasts ... estimated $31 billion in 2011. This value is expected ... billion by 2017, with 10% CAGR during the same ... hydraulic fracturing production market in terms of hydraulic horse ...
(Date:10/17/2014)... engineering professors have received a $451,781 Air Force Office ... at the micro- and nano-scale level that will provide ... professor of Mechanical and Aerospace Engineering, said the new ... than taking X-rays of an aircraft,s wing., "We,ll be ... when we look at it on this scale," Huang ...
(Date:10/17/2014)... October 17, 2014 For the ... employers, as published in today’s print issue of ... annual Top Employers Survey polled employees in the ... 20 best employers. Rankings were determined based ... to rate their companies on 23 characteristics, including ...
Breaking Biology Technology:The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4UT Arlington project to detect possible damages in aircraft parts early in process 2DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... , ... Indianapolis (PRWEB) April 29, ... subsidiary of The Dow Chemical Company (NYSE:DOW), have demonstrated insertion ... pre-determined location in the maize genome confirming that precise modification ...
... Calif., April 29 Sangamo BioSciences, Inc. (Nasdaq: ... of its zinc finger DNA-binding protein (ZFP) technology. ... Nature by licensing partner Dow AgroSciences and ... for the efficient generation of maize plants with ...
... has added four, six and eight port right-angle BNC connectors to ... cost savings as a replacement for applications where a number of ... , ... Sunnyvale, CA (PRWEB) April 29, 2009 -- Regal ...
Cached Biology Technology:Dow AgroSciences Confirms Efficacy of Zinc Finger Nucleases for Precise Genome Modification in Maize 2Dow AgroSciences Confirms Efficacy of Zinc Finger Nucleases for Precise Genome Modification in Maize 3Sangamo BioSciences Announces Publication in Nature of the Use of Zinc Finger Nucleases to Accelerate Precision Trait Stacking in Commercial Crop Species 2Sangamo BioSciences Announces Publication in Nature of the Use of Zinc Finger Nucleases to Accelerate Precision Trait Stacking in Commercial Crop Species 3Sangamo BioSciences Announces Publication in Nature of the Use of Zinc Finger Nucleases to Accelerate Precision Trait Stacking in Commercial Crop Species 4Regal Introduces Four, Six and Eight Port Filtered and Un-Filtered Right Angle BNC Connectors 2
... The Synaptic Vesicles Isolation Kit ... preparing an enriched synaptic vesicle fraction. ... hypo-osmotic lysis of the synaptosomes, and ... density gradient. The kit also contains ...
... Silica Bead Kit has been designed for recovery of ... Features Ultra fast protocol: DNA ... silica beads are easy to resuspend Bead uniformity ... pure DNA (suitable for PCR) DNA is eluted ...
... The kit provides a simple and efficient method ... and from PCR mixes. DNA fragments selectively absorbed ... for gel extraction or at room temperature for ... Up to 25 g of DNA can be ...
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human HLA-DR TAC is designed to deplete human HLA-DR from samples to isolate resting CD4+ or CD8+ T cells....
Biology Products: