Navigation Links
Scientists discover an epigenetic cause of osteoarthritis
Date:7/6/2012

Bethesda, MDIn what could be a breakthrough in the practical application of epigenetic science, U.K. scientists used human tissue samples to discover that those with osteoarthritis have a signature epigenetic change (DNA methylation) responsible for switching on and off a gene that produces a destructive enzyme called MMP13. This enzyme is known to play a role in the destruction of joint cartilage, making MMP13 and the epigenetic changes that lead to its increased levels, prime targets for osteoarthritis drug development. In addition to offering a new epigenetic path toward a cure for osteoarthritis, this research also helps show how epigenetic changes play a role in diseases outside of cancer. This finding was recently published online in the FASEB Journal.

"As the population gets older, osteoarthritis presents increasing social and economic problems," said David A. Young, Ph.D., a researcher involved in the work from the Musculoskeletal Research Group at the Institute of Cellular Medicine at Newcastle University in Newcastle upon Tyne in the United Kingdom. "Our work provides a better understanding of the events that cause cartilage damage during osteoarthritis and provides hope that tailored drug development to prevent the progress of disease will improve the quality of life and mobility of many arthritis sufferers."

To make the discovery, Young and colleagues compared the extent to which DNA methylation was different in cartilage from patients suffering from osteoarthritis and healthy people of similar age. They found that at one small position, the gene for MMP13 had less DNA methylation in diseased patients. Then they confirmed that reduced methylation of this gene increases levels of the destructive enzyme MMP13.

"We've already seen how epigenetics has advanced our approach to cancer. Now we're seeing it with other diseases and even exercise." said Gerald Weissmann,
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. New York University scientists discover possible treatment to reduce scarring
2. Scientists discover new trigger for immense North Atlantic plankton bloom
3. Atmospheric scientists release first bottom-up estimates of Chinas CO2 emissions
4. Stanford scientists find molecule to starve lung cancer and improve ventilator recovery
5. Scripps Florida scientists identify critical quality control for cell growth
6. Gladstone scientists identify critical process in stem cell development
7. Wholly water -- students and scientists gather at NTU to discuss water problem
8. Cancer scientists link ‘oncometabolite’ to onset of acute myeloid leukemia
9. Rensselaer scientists unlock some key secrets of photosynthesis
10. Scripps Research Institute Scientists Develop Alternative to Gene Therapy
11. Scientists urge new approaches to plant research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/14/2015)... YORK , May 14, 2015 /PRNewswire/ ... in identity verification and online remote proctoring, ... a software-as-a-service (SaaS) company and creator of ... customers of the two companies will benefit ... in Canvas. As a fully ...
(Date:5/11/2015)... 11, 2015 Curemark LLC, a privately held ... a new Phase III double blind, randomized, placebo-controlled clinical ... CM-AT, on all children ages 3-8 with Autism. Previously, ... III double blinded clinical trial for CM-AT in children ... the digestive enzyme chymotrypsin. This new trial will help ...
(Date:5/7/2015)... Sweden , May 7, 2015 ... touch fingerprint sensors, FPC1022 and FPC1035, FPC,s smallest ... and FPC1035 are mainly considered for integration on ... size gives smartphone OEMs increased possibilities to integrate ... The decreased size also improves possibilities for module ...
Breaking Biology News(10 mins):Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2
... rates are concentrated in the northern part of the ... according to a report in Cancer Epidemiology, Biomarkers ... for Cancer Research. Ahmedin Jemal, D.V.M., Ph.D., vice ... said the decrease in death rates ranged from about ...
... global cooling and warming over the past few million ... they do today, according to a new study by ... The researchers, who analyzed California gray whale ( Eschrichtius ... 120,000 years, also found evidence to support the idea ...
... Move over, boy bands of Americathere,s a new ... Middle School in San Diego, California, entered The Christopher ... (STEM) program that challenges middle-school students to identify a ... Taking a cue from the popular group the Backstreet ...
Cached Biology News:Southern US states lag in reducing death rates from colorectal cancer 2Gray whales likely survived the Ice Ages by changing their diets 2Gray whales likely survived the Ice Ages by changing their diets 3Gray whales likely survived the Ice Ages by changing their diets 4Gray whales likely survived the Ice Ages by changing their diets 5Middle-school students educate community on proper computer posture 2
(Date:5/26/2015)... Kalifornien und HILDEN, Deutschland, May 26, 2015 ... Insight ®   ermöglicht ... die Erstellung dazugehöriger Berichte; Vorstellung auf den ... QIAGEN N.V. (NASDAQ: QGEN ; ... Markteinführung von QIAGEN Clinical Insight ® ...
(Date:5/26/2015)... RICHMOND, Calif. , May 26, 2015  Sangamo BioSciences, ... Lanphier , Sangamo,s president and CEO, will provide an update ... programs and an overview of the company,s business strategy at ... 2015 Global Healthcare Conference. The conference is being held in ... presentation will be webcast live and may be accessed via ...
(Date:5/26/2015)... May 26, 2015  Alere Inc. (NYSE: ALR ) ... failure to timely file its Quarterly Report on Form 10-Q ... 10-Q"), it has received a notice from the New York ... compliance with the NYSE,s continued listing requirements under the timely ... Company Manual. The reason for the delay ...
(Date:5/26/2015)... 26, 2015 Global Stem Cells ... plans for the company’s first cellular and regenerative medicine ... a full day, hands-on stem cell training class Oct. ... Garcia Gimenez, M.D., President of Therapeutic Confrontations (CONFTERA) in ... increasing interest in regenerative medicine and recent advances in ...
Breaking Biology Technology:QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 2QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 3QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 4QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 5QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 6Sangamo BioSciences Announces Presentation At The Jefferies 2015 Global Healthcare Conference 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 3
... members help guide non-profit on path to cure ... Project, a Minnesota,non-profit organization created to expedite the ... attracted two well-known experts to its,Board of Directors: ... (Logo: http://www.newscom.com/cgi-bin/prnh/20071214/CLF057LOGO-b ), Steven D. ...
... 16 Celator Pharmaceuticals today,announced that John Bennett, ... the BIO Business Forum during the Biotechnology Industry,Organization ... will,provide a corporate overview and an update on ... on Wednesday, June 18,2008 at 3:30 PDT in ...
... NovaVision today announced,the appointment of Rudy Mazzocchi as ... is responsible for leveraging the company,s novel,technology to ... patients with,impaired vision have access to NovaVision(R) Vision ... expertise bringing new medical technologies,and devices to market ...
Cached Biology Technology:Spring Point Project Names New Members to Board of Directors 2NovaVision Appoints Medical Technology Veteran Rudy Mazzocchi as Chief Executive Officer 2NovaVision Appoints Medical Technology Veteran Rudy Mazzocchi as Chief Executive Officer 3
Extra Large bottle for hybridization 300 x 70mm...
Request Info...
... is TWO ROTORS in ONE! Now, you ... can spin both 1.5 - 2.0 ml ... design provides excellent chemical resistance and can ... fully compatible with common decontamination methods, including ...
... compatible with hood installations. ... system for 384-well plates, ... prepares large quantities of ... Wellpro also performs plate ...
Biology Products: