Navigation Links
Scientists discover a new way our bodies control blood pressure: the P450-EET system

If you are one of the millions of Americans with high blood pressure, more help is on the way. That's because a new research study published in the October 2010 print issue of The FASEB Journal ( shows that a protein, called P450, metabolizes arachidonic acid in our blood vessel walls to create a tiny molecule with a big nameepoxyeicosatrienoic acid (EET)which in mice, turns off genes responsible for vascular inflammation and ultimately relaxes blood vessels to lower blood pressure. This protein and genes are also present in humans.

"We hope these results will help advance the development of new blood pressure lowering agents that increase EETs," said Craig R. Lee, M.D., from the National Institutes of Health's National Institute of Environmental Health Sciences in Research Triangle Park, N.C. "In particular, we hope that targeted-use of these new therapies in individuals with a poorly functioning P450-EET system will ultimately prove to be an effective treatment for patients with high blood pressure."

Lee and colleagues discovered this new protein using genetically modified mice with human P450 present in the cells lining the blood vessels, and using normal mice as a control group. The scientists found that the P450 caused the mice to produce EETs, which in turn caused the relaxation of blood vessels and lower blood pressure. When the mice were exposed to substances that increased blood pressure, the P450 mice had lower blood pressure and less damage to the kidneys than the normal mice. These results show that the P450-EET pathway is a target for the development of new blood pressure medications, and these findings may influence drug development for other diseases, such as coronary artery disease, stroke, and cancer.

"Whether you're a Type A personality, overweight and out of shape, or genetically wired to have high blood pressure, this research offers real hope," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal "Having discovered a pivotal role for the P450-EET system, scientists can now develop a new class of drugs not only for lowering blood pressure, but also for preventing strokes and heart attacks."


Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Related biology news :

1. Scientists reveal important clues to how bacteria and viruses are identified as enemies
2. Going green: New program provides vital support for plant scientists
3. Notre Dame and Wyoming scientists genetically engineer silkworms to produce artificial spider silk
4. Hepatitis C virus faces new weapon from Florida State scientists
5. Light workout: Stanford scientists use optogenetics to effectively stimulate muscle movement in mice
6. Scientists release first cultivated ohelo berry for Hawaii
7. Fruit flies help Yale scientists sniff out new insect repellents
8. Marine scientists unveil the mystery of life on undersea mountains
9. Scientists uncover process enabling toxoplasmosis parasite to survive homelessness
10. Scientists show Six3 gene essential for retinal development
11. Warrior worms discovered in snails; UCSB scientists see possible biomedical applications
Post Your Comments:
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting Medicaid ... setting a new clinical standard in telehealth thanks to ... leveraging the higi platform, IMPOWER patients can routinely track ... and body mass index, and, when they opt in, ... convenient visit to a local retail location at no ...
(Date:3/23/2016)... , March 23, 2016 ... erhöhter Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender ... das Unternehmen mit SpeechPro zusammenarbeitet, um erstmals ... Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im Rahmen ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche ... with peritoneal or pleural mesothelioma. Their findings are the subject of a new article ... Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, into ... for over 35 years, is proud to add Target to its list of ...
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
Breaking Biology Technology: