Navigation Links
Scientists discover a new way our bodies control blood pressure: the P450-EET system
Date:9/30/2010

If you are one of the millions of Americans with high blood pressure, more help is on the way. That's because a new research study published in the October 2010 print issue of The FASEB Journal (http://www.fasebj.org) shows that a protein, called P450, metabolizes arachidonic acid in our blood vessel walls to create a tiny molecule with a big nameepoxyeicosatrienoic acid (EET)which in mice, turns off genes responsible for vascular inflammation and ultimately relaxes blood vessels to lower blood pressure. This protein and genes are also present in humans.

"We hope these results will help advance the development of new blood pressure lowering agents that increase EETs," said Craig R. Lee, M.D., from the National Institutes of Health's National Institute of Environmental Health Sciences in Research Triangle Park, N.C. "In particular, we hope that targeted-use of these new therapies in individuals with a poorly functioning P450-EET system will ultimately prove to be an effective treatment for patients with high blood pressure."

Lee and colleagues discovered this new protein using genetically modified mice with human P450 present in the cells lining the blood vessels, and using normal mice as a control group. The scientists found that the P450 caused the mice to produce EETs, which in turn caused the relaxation of blood vessels and lower blood pressure. When the mice were exposed to substances that increased blood pressure, the P450 mice had lower blood pressure and less damage to the kidneys than the normal mice. These results show that the P450-EET pathway is a target for the development of new blood pressure medications, and these findings may influence drug development for other diseases, such as coronary artery disease, stroke, and cancer.

"Whether you're a Type A personality, overweight and out of shape, or genetically wired to have high blood pressure, this research offers real hope," said
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists reveal important clues to how bacteria and viruses are identified as enemies
2. Going green: New program provides vital support for plant scientists
3. Notre Dame and Wyoming scientists genetically engineer silkworms to produce artificial spider silk
4. Hepatitis C virus faces new weapon from Florida State scientists
5. Light workout: Stanford scientists use optogenetics to effectively stimulate muscle movement in mice
6. Scientists release first cultivated ohelo berry for Hawaii
7. Fruit flies help Yale scientists sniff out new insect repellents
8. Marine scientists unveil the mystery of life on undersea mountains
9. Scientists uncover process enabling toxoplasmosis parasite to survive homelessness
10. Scientists show Six3 gene essential for retinal development
11. Warrior worms discovered in snails; UCSB scientists see possible biomedical applications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... at the University of East Anglia have shown how ... growth in cancer patients. , Research published today ... are responsible for the drug,s success in shrinking tumours. ... help develop a synthetic equivalent with anti-cancer properties. ... Complutense de Madridin, Spain. The team used samples of ...
(Date:7/13/2014)... in women suggests that experiencing one or more stressful ... can slow the body,s metabolism, potentially contributing to weight ... day,s stressors before giving them a meal consisting of ... then measured their metabolic rate how long it ... and took measures of blood sugar, triglycerides, insulin and ...
(Date:7/11/2014)... Wildlife Conservation Society shows that no-take zones in ... such as lobster, conch, and fish recover from ... areas. , The reporttitled "Review of the Benefits ... literature from no-take areas around the world. The ... recognized expert in marine protected areas and fisheries ...
Breaking Biology News(10 mins):UEA research reveals how cannabis compound could slow tumour growth 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 3Weighty issue: Stress and high-fat meals combine to slow metabolism in women 4Belize's lobster, conch, and fish populations rebuild in no-take zones 2
... appears to have "snipped off the ends" of its ... that infects human cells, according to research published today ... E. cuniculi , a parasitic fungus commonly found ... humans, has been widely regarded as having the smallest ...
... Global Rainmakers, Inc. (GRI), a Puerto Rico based ... today announced the appointment of James Demitrieus as Chief ... firm operations as it diversifies its product offering ... comes to GRI with over 30 years of ...
... fan out on Capitol Hill on Tuesday to engage ... to practice communicating the importance of supporting scientific discovery ... The undergraduate and graduate students participating in "Hill ... Molecular Biology, have a number of messages they intend ...
Cached Biology News:Genomic 'haircut' makes world's tiniest genome even smaller: UBC research 2Global Rainmakers Appoints James M. Demitrieus as Chief Operating Officer 2Global Rainmakers Appoints James M. Demitrieus as Chief Operating Officer 3‘Scientific leaders of the future’ gear up for important talks on Capitol Hill 2‘Scientific leaders of the future’ gear up for important talks on Capitol Hill 3
(Date:7/14/2014)... Canada (PRWEB) July 14, 2014 ... executives from across the clinical trials space, representing ... eCongress webinar series entitled “Optimizing Patient Participation in ... eCongress kicked off with internationally renowned R&D expert, ... Keynote address on Reinventing Drug Development through Patient ...
(Date:7/13/2014)... 2014 Deep Research Report on Global and China ... on the current state of the Nano Silver industry ... basic overview of the industry, including definitions, applications and ... market analysis are provided with a focus on history, ... comparison between the international and Chinese situation is also ...
(Date:7/11/2014)... 11, 2014 Research and Markets  has ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... http://photos.prnewswire.com/prnh/20130307/600769 ... (either DNA or RNA) into cells. This technology helps ... cells and protein metabolism by affecting the nuclear genes. ...
(Date:7/11/2014)... SEATTLE , July 11, 2014  Researchers ... navigate three-dimensional images. The new technology, called Virtual ... of small structures like neurons and synapses using ... Finger,s unique technology makes 3D imaging studies orders ... resources at an unprecedented level across many areas ...
Breaking Biology Technology:Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 3Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 4Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 52014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3
... SHANGHAI, China, Aug. 22 /Xinhua-PRNewswire-FirstCall/ --,China-Biotics, Inc. ... leading Chinese firm specializing in the manufacture,research, ... today that it has signed an agreement ... Dairy") (SSE: 600597) to supply probiotics for ...
... UniCare,s HealthWave Members with Valuable Local ... ... Health Plan of Kansas,Inc. today announced the opening of its first ... enrollees living in,the Topeka area, the CRC will provide access to ...
... - Canadian Biotechnology Company confirms commercial expression levels ... variant and clarifies status of native Apo AI ... Genetics Inc.,(TSX:SBS), a biotechnology company developing a portfolio ... updated a release,issued on July 12, 2007 announcing ...
Cached Biology Technology:China-Biotics, Inc. Signs Intention Agreement to Supply Probiotics to Bright Dairy & Food Co., Ltd. 2China-Biotics, Inc. Signs Intention Agreement to Supply Probiotics to Bright Dairy & Food Co., Ltd. 3UniCare Unveils Community Resource Center in Topeka to Serve Medicaid Enrollees 2SemBioSys updates Apo AI development program 2SemBioSys updates Apo AI development program 3SemBioSys updates Apo AI development program 4
...
... Arrays can be used to test the ... and sera that are commonly used as ... contains spots for 21 different protein preparations ... antibody crossreactivity and species specificity, QC of ...
... DNA sequencing is the experimental process ... DNA region. The automated DNA Sequencing is ... thermostable DNA polymerase, which allows cycle sequencing ... and detected in a capillary instrument controlled ...
... On-Demand Cytometry The Guava ... blue laser based multiparameter cytometer with built-in ... you can screen plates of cells and ... of manipulating multiple tubes or having the ...
Biology Products: