Navigation Links
Scientists discover a molecular scaffold that guides connections between brain cells
Date:5/20/2008

arts of other neurons, such as the dendrites. Dr. Huang likens this process to the address on a letter that brings it from another country directly to your door by specifying the country, state, city, street, and house number. He and other brain researchers have learned much about the higher levels of this addressing scheme, identifying, for instance, chemical signals that guide axons to the right section of the brain, and different signals that lead them to the appropriate layer within that section.

How Neurons Form Synapses

Only recently, however, have Dr. Huang and his colleagues traced the chemical signals leading neurons to form synapses with specific parts of other neurons. Such sub-cellular specificity is critical to ensure the precision and reliability of communication among neurons. Synapses are the tiny gaps across which nerve cells exchange signals, conveyed by chemicals called neurotransmitters.

A few years ago, Dr. Huangs team established that a protein from the immunoglobulin family directs one group of cerebellar neurons to connect with a specific part of Purkinje cells. Immunoglobulin proteins are best known for acting as antibodies in the immune system, where they take on myriad forms to attack new invaders. Here, however, they are observed to be involved in the wiring of the brain.

The striking feature is that there is a lot of capacity for variety in immunoglobulin molecules, Dr. Huang explains. In the nervous system, their versatility may help them guide cells to form synapses with specific partners. Intriguingly, Dr. Huang adds, immunoglobulins have been implicated in neural developmental disorders, such as autism. There is good evidence that these disorders involve miswiring of the nervous system, Dr. Huang says, which may reflect a problem with immunoglobulin-guided synapse formation.

A Guiding Scaffold Made of Glial Cells

In the work reported in their newly published p
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Nxt-ID, Inc. (OTCQB: NXTD), a biometric authentication ... today that its shares of common stock and the ... its proposed underwritten public offering of common stock and ... Capital Market, subject to closing of its proposed underwritten ... will trade under the symbol "NXTD" and "NXTDW," respectively. ...
(Date:8/21/2014)... seem easy to ignore, but they are the ultimate ... upon. Humans are increasingly dependent on algae, too, to ... sink it to the bottom of the ocean. Now, ... experiments, researchers have evidence showing that viruses infecting those ... blooms, even when all else stays essentially the same, ...
(Date:8/21/2014)... MELBOURNE, Fla. , Aug. 21, 2014 ...  announced that it has agreed to a ... Orlando,s fastest growing Certified ... make  Gabriel Health Institute  an exclusive member ... a result, Binary Biometrics will improve its ...
Breaking Biology News(10 mins):Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3Viruses take down massive algal blooms, with big implications for climate 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3
... Darwin, the "tree of life" has been the preeminent metaphor ... changing of individual species. The discovery that a large ... species of fungus to another, however, significantly strengthens the argument ... more appropriate. "The fungi are telling us something important ...
... fear. And they know to fear the scent of a predator. ... that a cat is nearby? It,s a complex process ... in their noses. But until now it wasn,t clear exactly how ... In a study to be published in Nature ...
... available in Spanish . The link between ... depressive disorders is not new in the medical field. However, what ... which diet can condition mental health to a certain extent. Research ... Medicine and Odontology of the University of the Basque Country (UPV/EHU) ...
Cached Biology News:Discovery of jumping gene cluster tangles tree of life 2Discovery of jumping gene cluster tangles tree of life 3The brain knows what the nose smells, but how? Stanford researchers trace the answer 2The brain knows what the nose smells, but how? Stanford researchers trace the answer 3Scientific research reveals brain alterations linking omega 3 deficit with depression 2Scientific research reveals brain alterations linking omega 3 deficit with depression 3
(Date:8/20/2014)... the first time, chemists have succeeded in measuring vibrational ... resolution. The study reveals how vibration of a single ... , The study was performed at the University ... the University of Jyvskyl works as a visiting fellow ... the study. The second team was lead by Professor ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 High ... and apply the most complete climate and Earth ... demanding climate change issues. , Eight national laboratories, ... with the National Center for Atmospheric Research, four ... new effort. Other participating national laboratories include Argonne, ...
(Date:8/20/2014)... -- PAREXEL International Corporation (NASDAQ: PRXL ) announced ... Healthcare Conference in New York.  Ingo Bank , ... making a presentation on PAREXEL and discussing business developments ... A live webcast of the discussion will ... at www.PAREXEL.com in the Upcoming Events portion ...
(Date:8/20/2014)... Canada (PRWEB) August 20, 2014 Not ... that E&L studies should be performed late in the ... is known. But current regulatory trends suggest that, like ... on the rise. In recent years, multiple drug sponsors ... packages or address specific questions during phase I/II. It’s ...
Breaking Biology Technology:Seeing a molecule breathe 2New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3PAREXEL International To Present At Baird Healthcare Conference 2Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2
... Interleukin Genetics, Inc. (OTCQB: ILIU) announced today ... Thursday, November 10 at 4:30 p.m. (EST) to discuss the ... call, dial 877-324-1976 (domestic) or 631-291-4550 (international). The live Webcast ... the Investors section of Interleukin Genetics, Inc.,s Website at ...
... Cumberland Pharmaceuticals Inc. (NASDAQ: CPIX ), ... gastroenterology markets, today announced third quarter 2011 financial results. ... September 30, 2011, net revenue was $13.1 million, up from ... net revenue was driven by an increase in sales of ...
... NEW YORK, Nov. 3, 2011 Reportlinker.com announces ... in its catalogue: Global ... http://www.reportlinker.com/p0619270/Global-Biochip-Markets-Microarrays-and-Lab-on-a-Chip.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=NoCategory INTRODUCTION  ... BCC,s goal for this study ...
Cached Biology Technology:Interleukin Genetics, Inc. Announces Conference Call to Discuss Third Quarter 2011 Results 2Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 2Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 3Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 4Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 5Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 6Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 7Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 8Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 9Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 10Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 11Cumberland Pharmaceuticals Reports Third Quarter 2011 Financial Results 12Global Biochip Markets: Microarrays and Lab-on-a-Chip 2Global Biochip Markets: Microarrays and Lab-on-a-Chip 3Global Biochip Markets: Microarrays and Lab-on-a-Chip 4Global Biochip Markets: Microarrays and Lab-on-a-Chip 5
(3-[125I]iodotyrosyl26)Galanin (porcine), 925 kBq, 25 uCi. Category: IODINE LIGANDS....
Immunogen: Synthetic Peptide: V(22) N G H E F E I E G E G E G R(36) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Mouse Endoglin/CD105 Fluorescein MAb (Clone 209701)...
Catalase (Control)...
Biology Products: