Navigation Links
Scientists discover a molecular scaffold that guides connections between brain cells
Date:5/20/2008

Brain cells known as neurons process information by joining into complex networks, transmitting signals to each other across junctions called synapses. But neurons dont just connect to other neurons, emphasizes Z. Josh Huang, Ph.D., in a lot of cases, they connect to very specific partners, at particular spots.

Dr. Huang, a professor at Cold Spring Harbor Laboratory (CSHL), leads a team that has identified molecules guiding this highly specific neuronal targeting in the developing brains of mice. The researchers report in PLoS Biology that in some cases, these molecular guides -- non-signaling brain cells known as glia -- form a kind of scaffold. This scaffold, in turn, directs the growth of nerve fibers and their connections between specific types of neurons.

As they learn through research like this how the brain develops its complex wiring, the scientists hope they can clarify what goes wrong in disorders like autism.

The Cerebellums Organized Architecture

Distinctive wiring patterns are unmistakable in the cerebellum, a brain region best known for controlling movement, in both mice and people. Compared to regions involved in more sophisticated functions like vision and thought, the cerebellum is an easier place to start, because of its very organized architecture, Dr. Huang says, although he notes that other parts of the brain have their own specific wiring patterns.

Central to the wiring architecture of the cerebellum are so-called Purkinje cells, a type of neuron that deploys a bushy array of fibers called dendrites that extend through layers of cerebellar territory. The dendrites gather signals from many other neurons in the cerebellum and send signals to other parts of the body.

The complex wiring pattern emerges during the early growth of the brain, when individual neurons migrate from their places of origin in other brain regions and emit filaments called axons that connect to particular p
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... -- According to a new market ... Services), by Applications (Surveillance (Airborne, Maritime, Land), Threat ... & Defense & Commercial) - Global Forecast to ... expected to grow from $7252.0 Million in 2015 ... Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/19/2015)... YORK , May 19, 2015  Technology is ... both internally and in the cloud. Passwords and their ... use of OTP and standards-based specifications such as those ... the outmoded use of passwords presents for BYOD, COPE, ... a unified biometric identity protocol. In ...
(Date:5/11/2015)... 2015  Synaptics Incorporated (NASDAQ: SYNA ), ... announced the appointment of Wajid Ali ... reporting to Rick Bergman , President and ... Officer, Kathleen Bayless , who announced her ... Ali brings extensive financial management expertise to Synaptics, ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... and the Veterans Affairs Greater Los Angeles Healthcare System ... the cost-effectiveness of current modern drugs for treating hepatitis ... Published in the May 17 Annals of Internal Medicine, ... decisions. Researchers note that a degree of uncertainly exists ...
... known for a long time that only 2% -- 3% ... of our genomes -- often referred to as junk DNA ... RNA, reverse-transcribed into DNA, and then reinserted into a new ... class of these retroelements. Retroviruses can insinuate themselves into the ...
... Don't miss out the cool movies, link at the end ... Medicine researchers have found a way to exercise a little ... their wings, and fly on command by triggering genetic "remote ... central nervous systems, according to a new report in the ...
Cached Biology News:UCLA study assesses cost-effectiveness of Hepatitis B drugs 2UCLA study assesses cost-effectiveness of Hepatitis B drugs 3Chimp genome reveals a retroviral invasion 2Chimp genome reveals a retroviral invasion 3Remote control flies? Fly behavior controlled by laser light 2Remote control flies? Fly behavior controlled by laser light 3
(Date:6/1/2015)... -- Neogen Corporation (NASDAQ: NEOG ) announced today that it ... commercial food testing laboratory based in southwest India ... a base for the company,s new operations in ... was incorporated in 1990, and its business has grown ... quality testing for major hotels and restaurants in its home ...
(Date:6/1/2015)... June 01, 2015 Sistemic Ltd. ... entered into a commercial collaboration agreement and signed ... combine their technologies and work together towards advancing ... technology. RoosterBio and Sistemic will collaborate on utilizing ... build more precise and relevant characterization panels for ...
(Date:6/1/2015)... La. , June 1, 2015 Esperance ... II trial of lead candidate EP-100 in ovarian cancer ... peptide designed to seek and destroy cancer cells that ... LHRH receptors are over-expressed in a wide range of ... multi-center Phase II trial of EP-100 were presented ...
(Date:6/1/2015)... 1, 2015  Berg, a biopharmaceutical company committed to ... clinical research from its trials using its cancer drug ... data on triple negative breast cancer, at the 51 ... Clinical Oncology (ASCO), May 29 – June 2 in ... 31510 is one of the first cancer drugs guided ...
Breaking Biology Technology:Neogen acquires India food safety company 2Sistemic and RoosterBio Inc Announce Broad Collaboration Agreement to Advance miRNA and Mesenchymal Stem/Stromal Cell (MSC) Regenerative Technology 2Sistemic and RoosterBio Inc Announce Broad Collaboration Agreement to Advance miRNA and Mesenchymal Stem/Stromal Cell (MSC) Regenerative Technology 3Sistemic and RoosterBio Inc Announce Broad Collaboration Agreement to Advance miRNA and Mesenchymal Stem/Stromal Cell (MSC) Regenerative Technology 4Esperance Reports Positive EP-100 Phase ll Results in Ovarian Cancer at 2015 ASCO Annual Meeting 2Esperance Reports Positive EP-100 Phase ll Results in Ovarian Cancer at 2015 ASCO Annual Meeting 3Berg Presents Data On BPM 31510 Solid Tumor Trial At ASCO Annual Meeting That Reveals The Promise Of Metabolically Driven Therapy 2Berg Presents Data On BPM 31510 Solid Tumor Trial At ASCO Annual Meeting That Reveals The Promise Of Metabolically Driven Therapy 3
... Technologies LLC (Myriant), a privately-held, biotech developer and ... its Science Advisory Board and the appointment of ... will provide broad insight into all aspects of ... feedstocks into valuable chemicals. , (Logo: ...
... N.C., Oct. 21 Cornerstone Therapeutics Inc. (Nasdaq CM: ... and commercializing significant products primarily for the respiratory and ... conference call at 8:30 AM ET on Wednesday, November ... quarter ended September 30, 2009. Management will also ...
... ... business models capture investors, interest. , ... Miami, FL (PRWEB) October 21, 2009 -- iLife Americas, LLC, a ... in the U.S. to market its line of iLife wellness and therapeutic products. Officially ...
Cached Biology Technology:Myriant Technologies LLC Announces Appointment of Science Advisory Board Members 2Myriant Technologies LLC Announces Appointment of Science Advisory Board Members 3Cornerstone Therapeutics to Host Third Quarter 2009 Conference Call 2Cornerstone Therapeutics to Host Third Quarter 2009 Conference Call 3iLife Americas, LLC Enters U.S. Wellness and Therapeutic Markets 2
...
5 minutes from gel band to purified DNA...
Sterile concentration of Dithiothreitol (DTT) solution in phosphate buffer (pH 7.0). Dilute contents in one vial (10- fold) to 100 ml. For use in liquefying sputum samples....
...
Biology Products: