Navigation Links
Scientists discover 3 new gene faults which could increase melanoma risk by 30 percent
Date:10/9/2011

An international team of researchers has discovered the first DNA faults linked to melanoma - the deadliest skin cancer - that are not related to hair, skin or eye colour.

Cancer Research UK scientists at the University of Leeds, together with a team from the GenoMEL consortium*, scanned the genes in blood samples from almost 3000 Europeans with melanoma, and compared these with samples taken from the general population. Their findings are published in Nature Genetics today.**

Known risk factors for melanoma include fair skin, blue or green eyes, blond or red hair, a high number of moles, people who burn easily and those who have a family history.

Previous research by these and other scientists identified five pigmentation genes and three 'mole formation' genes, linked to melanoma risk. But the scientists have now discovered three new risk genes not associated with pigmentation or moles***.

Four per cent of the UK population****, around 2.3m people, will carry two copies of all three gene faults (one copy inherited from each parent). The average risk of developing melanoma is about one in 60. This goes up to one in 46 if a person has both copies of all three gene faults.

Lead author, Professor Tim Bishop, based in the Cancer Research UK centre at the University of Leeds, said: "We know that overexposure to UV increases the risk of developing melanoma but this evidence shows that there are new additional genetic faults which can push up the risk further.

"It is fascinating to discover these new melanoma risk factors and we expect that the results of similar studies underway will reveal even more."

Dr Lesley Walker, Cancer Research UK's director of cancer information, said: "These intriguing results provide deeper understanding of the causes of melanoma and provide a potential new approach to identify people most at risk of developing melanoma and other cancers."

One DNA fault was found in the region of a gene called MX2 linked to narcolepsy a disease thought to be triggered by the immune system which causes people to fall asleep spontaneously.

Another fault was found in a gene called ATM involved in DNA repair preventing cancer-causing mistakes being passed onto daughter cells.

The third gene fault was found in the CASP8 gene, which plays a role in controlling cell spread by triggering automatic cell death.

There are around 11,770 new cases of malignant melanoma diagnosed each year in the UK and these are mainly caused by overexposure to UV light. Almost one third of all cases of malignant melanoma occur in people under 55. Over the last twenty-five years, rates of malignant melanoma in Britain have risen faster than any of the most common cancers.

Dr Lesley Walker added: "Cancer Research UK has invested heavily in research to identify tiny DNA changes to paint an overall picture of which regions of DNA could be linked to cancer and we hope that research like this will reveal further genetic secrets to help us diagnose and treat the disease.

"The best way to reduce the risk of skin cancer, is to protect yourself from strong sun by covering up with clothing, spending some time in the shade, and applying at least SPF 15 sunscreen with four or more stars generously and regularly."


'/>"/>

Contact: Paula Gould
p.a.gould@leeds.ac.uk
44-113-343-8059
University of Leeds
Source:Eurekalert

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
(Date:3/14/2016)... NXTD ) ("NXT-ID" or the "Company"), a company ... of a new series of commercials on Time Warner Cable ... .  The commercials will air on Bloomberg TV, Fox Business ... show. --> NXTD ) ("NXT-ID" or the "Company"), ... the airing of a new series of commercials on Time ...
(Date:3/11/2016)... March 11, 2016 http://www.apimages.com ) - ... Picture is available at AP Images ( http://www.apimages.com ) - ... be used to produce the new refugee identity cards. DERMALOG will ... at CeBIT in Hanover next week.   ... will be used to produce the new refugee identity cards. DERMALOG ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... Ohio (PRWEB) , ... May 23, 2016 , ... ... Trends That Will Drive Precision Farming in 2017 and Beyond. The paper outlines ... practitioners in the precision ag industry. , “We’ve witnessed a lot of highs ...
(Date:5/23/2016)... , May 23, 2016 Oxitec ... 25 th at 10:15 a.m. ET before the United ... role genetically engineered mosquitos can play in controlling the spread ... of the Zika virus.      (Logo: http://photos.prnewswire.com/prnh/20150630/227348 ... male mosquito with a self-limiting gene. Trials in ...
(Date:5/23/2016)... ... May 23, 2016 , ... RoviSys, a ... based in Aurora, Ohio, has broken ground on a new building in Holly ... Park area, this new location solidifies a commitment to business in the region. ...
(Date:5/22/2016)... NC (PRWEB) , ... May 22, 2016 , ... Doctors ... weapons in combating the asbestos cancer, malignant mesothelioma. Surviving Mesothelioma has just posted an ... Researchers in the University of Rome’s Department of Clinical Sciences and Translational Medicine evaluated ...
Breaking Biology Technology: