Navigation Links
Scientists develop promising drug candidates for pain, addiction
Date:1/13/2014

JUPITER, FL, January 13, 2014 Scientists from the Florida campus of The Scripps Research Institute (TSRI) have described a pair of drug candidates that advance the search for new treatments for pain, addiction and other disorders.

The two new drug scaffolds, described in a recent edition of The Journal of Biological Chemistry, offer researchers novel tools that act on a demonstrated therapeutic target, the kappa opioid receptor (KOR), which is located on nerve cells and plays a role in the release of the neurotransmitter dopamine. While compounds that activate KOR are associated with positive therapeutic effects, they often also recruit a molecule known as βarrestin2 (beta arrestin), which is associated with depressed mood and severely limits any therapeutic potential.

"Compounds that act at kappa receptors may provide a means for treating addiction and for treating pain; however, there is the potential for the development of depression or dysphoria associated with this receptor target," said Laura Bohn, a TSRI associate professor who led the study. "There is evidence that the negative feelings caused by kappa receptor drugs may be, in part, due to receptor actions through proteins called beta arrestins. Developing compounds that activate the receptors without recruiting beta arrestin function may serve as a means to improve the therapeutic potential and limit side effects."

The new compounds are called "biased agonists," activating the receptor without engaging the beta arrestins.

Research Associate Lei Zhou, first author of the study with Research Associate Kimberly M. Lovell, added, "The importance of these biased agonists is that we can manipulate the activation of one particular signaling cascade that produces analgesia, but not the other one that could lead to dysphoria or depression."

The researchers note that the avoidance of depression is particularly important in addiction treatment, where depressed mood can play a role in relapse.

The two drug candidates also have a high affinity and selectivity for KOR over other opioid receptors and are able to pass through the blood-brain barrier. Given these promising attributes, the scientists plan to continue developing the compounds.


'/>"/>
Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Related biology news :

1. Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists
2. Scientists solve 40-year mystery of how sodium controls opioid brain signaling
3. Harvard scientists control cells following transplantation, from the inside out
4. UCLA life scientists, colleagues differentiate microbial good and evil
5. Symbiotic fungi inhabiting plant roots have major impact on atmospheric carbon, scientists say
6. UMass Medical School faculty recognized as 1 of nations top young scientists
7. Scientists find a new mechanism underlying depression
8. Boost careers of female scientists: Make sure women help choose meeting speakers
9. MBL scientists to study coastal waterbird habitats through funding for Obamas Climate Action Plan
10. Scientists uncover image of muscular dystrophy defect & design targeted drug candidates
11. Scientists look to tackle bacterium that is major cause of diarrhea, vomiting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists develop promising drug candidates for pain, addiction
(Date:1/13/2017)... N.Y. , Jan. 13, 2017 ... technology solutions for the homecare industry, including Electronic ... homecare industry expert, Justin Jugs, as Senior Vice ... more than 15 years of homecare experience to ... in developing strategic plans to align Sandata,s suite ...
(Date:1/12/2017)... PORTLAND, Oregon and PUNE, India , January 12, 2017 ... Technology Market: Opportunities and Forecasts, 2015 - 2022," projects that the global biometric technology ... CAGR of 19.4% from 2016 to 2022. Continue Reading ... ... ...
(Date:1/6/2017)... Jan. 6, 2017  Privately-held CalciMedica, Inc., announced ... healthy volunteers of a novel calcium release-activated calcium ... pancreatitis. Acute pancreatitis, sudden painful ... disorder, but can be very serious.  In severe cases ... where extended hospital stays, time in the ICU ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... PA (PRWEB) , ... January 18, 2017 , ... ... operations again at the CHI SCOPE Summit for Clinical Ops Executives (Hyatt Regency ... engaging panel discussions to examine vital clinical research issues such as trial performance ...
(Date:1/18/2017)... ... ... Thirty-six startup companies in University City and Center City have been awarded ... Development in 2016 as part of the Keystone Innovation Zone (KIZ) Tax Credit Program. ... represent the highest number of awards to the largest number of companies in the ...
(Date:1/18/2017)... Jan. 18, 2017  Caris Life Sciences, a ... Foundation, the largest private funder of pancreatic cancer ... evaluating the impact of immunotherapy in the treatment ... enrollment services to identify potential trial candidates based ... treating physicians and study investigators. The Lustgarten Foundation ...
(Date:1/17/2017)... ... January 17, 2017 , ... LGC Maine ... its VALIDATE® SP2 calibration verification / linearity test kit. VALIDATE® SP2 evaluates Albumin, ... VALIDATE® SP2 kit is prepared using the CLSI recommended “equal delta” method for ...
Breaking Biology Technology: