Navigation Links
Scientists develop promising drug candidates for pain, addiction
Date:1/13/2014

JUPITER, FL, January 13, 2014 Scientists from the Florida campus of The Scripps Research Institute (TSRI) have described a pair of drug candidates that advance the search for new treatments for pain, addiction and other disorders.

The two new drug scaffolds, described in a recent edition of The Journal of Biological Chemistry, offer researchers novel tools that act on a demonstrated therapeutic target, the kappa opioid receptor (KOR), which is located on nerve cells and plays a role in the release of the neurotransmitter dopamine. While compounds that activate KOR are associated with positive therapeutic effects, they often also recruit a molecule known as βarrestin2 (beta arrestin), which is associated with depressed mood and severely limits any therapeutic potential.

"Compounds that act at kappa receptors may provide a means for treating addiction and for treating pain; however, there is the potential for the development of depression or dysphoria associated with this receptor target," said Laura Bohn, a TSRI associate professor who led the study. "There is evidence that the negative feelings caused by kappa receptor drugs may be, in part, due to receptor actions through proteins called beta arrestins. Developing compounds that activate the receptors without recruiting beta arrestin function may serve as a means to improve the therapeutic potential and limit side effects."

The new compounds are called "biased agonists," activating the receptor without engaging the beta arrestins.

Research Associate Lei Zhou, first author of the study with Research Associate Kimberly M. Lovell, added, "The importance of these biased agonists is that we can manipulate the activation of one particular signaling cascade that produces analgesia, but not the other one that could lead to dysphoria or depression."

The researchers note that the avoidance of depression is particularly important in addiction treatment, wher
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists
2. Scientists solve 40-year mystery of how sodium controls opioid brain signaling
3. Harvard scientists control cells following transplantation, from the inside out
4. UCLA life scientists, colleagues differentiate microbial good and evil
5. Symbiotic fungi inhabiting plant roots have major impact on atmospheric carbon, scientists say
6. UMass Medical School faculty recognized as 1 of nations top young scientists
7. Scientists find a new mechanism underlying depression
8. Boost careers of female scientists: Make sure women help choose meeting speakers
9. MBL scientists to study coastal waterbird habitats through funding for Obamas Climate Action Plan
10. Scientists uncover image of muscular dystrophy defect & design targeted drug candidates
11. Scientists look to tackle bacterium that is major cause of diarrhea, vomiting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists develop promising drug candidates for pain, addiction
(Date:9/18/2014)... researchers have developed a unique method to use microbes ... rural areas. , The first microbe-powered, self-sustaining wastewater ... way to clean up waste from large farming operations ... , Professor Haluk Beyenal and graduate student Timothy Ewing ... the system in the online edition of Journal ...
(Date:9/18/2014)... USA Miranda, a small, icy moon of Uranus, ... bodies in the solar system. Despite its relatively small ... intense resurfacing that resulted in the formation of at ... regions called coronae. , These coronae are visible ... least 200 km across. Arden corona, the largest, has ...
(Date:9/18/2014)... of researchers from McGill University and the Quebec ... polyethylene ,microbeads, Canadian Journal of Fisheries and ... from cosmetics, household cleansers, or industrial cleansers, to ... to their small size and buoyancy, they may ... are a global contaminant in the world,s oceans, ...
Breaking Biology News(10 mins):Researchers develop unique waste cleanup for rural areas 2Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Microplastic pollution discovered in St. Lawrence River sediments 2
... major reason that drugs are taken off the market and ... scientists are now reporting the development of a new way ... on the method, which could save patients from severe side ... ACS, Journal of Chemical Information and Modeling . ...
... of the world,s five egg-laying species of mammal, became extinct ... and colleagues have found evidence suggesting that not only did ... but that they may very well still exist in parts ... the Dec. 28, 2012 issue of the journal ...
... sea level over the past 40 million years, researchers ... that greenhouse gas concentrations similar to the present (almost ... levels at least nine metres above current levels. ... for CO2 concentrations ranging between ice-age values of 180 ...
Cached Biology News:Scientists discover that for Australia the long-beaked echidna may not be a thing of the past 2Scientists discover that for Australia the long-beaked echidna may not be a thing of the past 3New study documents the natural relationship between CO2 concentrations and sea level 2
(Date:9/18/2014)... Washington, D.C. (PRWEB) September 18, 2014 ... Dick Durbin and Sen. Jim Risch for National Lab ... research projects from across the national laboratory system. Durbin ... Caucus, which aims to increase awareness of the reach ... breakthrough technologies and discoveries to address some of our ...
(Date:9/18/2014)... 18, 2014 Research and Markets ... Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - ... offering. The global companion diagnostics market ... from 2014 to 2019. Factors such as rising need ... companion diagnostics by the pharmaceutical industry, support from regulatory ...
(Date:9/18/2014)... LEXINGTON, Ky. , Sept. 18, 2014  Neogen ... it has entered into a strategic agreement with Merck ... Heifer Program. The Igenity Dairy Heifer ... producers essential information on the genetic potential of replacement ... after a calf is born, and is an excellent ...
(Date:9/18/2014)... September 18, 2014 OMICS Group ... globe to participate in the ‘Open Access Week’ ... to OMICS Group Pharma Journals from ... of the fastest emerging Sciences, accelerating with a ... services across the globe. The industry is gearing ...
Breaking Biology Technology:Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3Merck Animal Health to market Neogen's dairy genomic program 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3
... Pharmaceuticals, Inc. (Nasdaq: ANDS ) announced today that ... on Wednesday, November 17, 2010 at 11:30 a.m. EST (8:30 ... Regis New York.  Steve Worland, Ph.D., President and Chief Executive ... its clinical development programs. The presentation will be ...
... Inc. announced today that the company has raised $7.1 ... The Series C round, which included 5 new investors, ... product VeriStrat®, a serum proteomic test that helps physicians ... (NSCLC). Existing shareholders of the company provided $5.1 million ...
... Business Unit Again Receives ,Best Places to Work in... -- SOUDERTON, Pennsylvania, November 10, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... shortURL = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, ...
Cached Biology Technology:Anadys Pharmaceuticals to Present at the Lazard Healthcare Conference 2Biodesix Completes Series C Financing and Receives Grant 2Biodesix Completes Series C Financing and Receives Grant 3Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 2Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 3Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 4Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 5Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 6Almac's Clinical Technologies Business Unit Again Receives 'Best Places to Work in PA 2010' Award 7
Immunogen: Synthetic Peptide: C N(185) D G T E F G G S I Y Q K(197) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Request Info...
Use the DUALmembrane kit 3 to carry out DUALmembrane interaction analysis and cDNA library screening to characterize interactions between integral membrane proteins and to identify novel interaction ...
... Quickly, effectively seals labware. Waterproof, ... protects anhydrous materials. Can be folded ... without rupturing. Stretched lengthwise at 21C ... Yet when tension is removed, film ...
Biology Products: