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Scientists develop new method to investigate origin of life
Date:9/2/2008

nt measures you have, the better view of the world you can get," he said.

In addition to searching for the origins of life, the team also is using its method to simultaneously gather data on the shapes of proteins, their functions in the body, and their evolutionary histories. In another paper, which was published in 2008 in the online journal Physics Archives, members of the team previously had demonstrated that their new method can simultaneously measure all three of these characteristics. "Previously, people have shown that profiling methods can resolve functional and structural differences and similarities between proteins, but to date no one has shown that you can measure evolutionary distances," said van Rossum. "Not only can our method measure evolutionary distances, but it also can measure functional and structural characteristics at the same time."

Patterson said that there are about 30,000 profiles in an online scientific repository that they can use to generate their phylogenetic profiles. He expects that the team's method will become even more powerful as additional sequences are added to this protein bank. In fact, the method already has become more refined in the short time since the team submitted its manuscript to the journal. "We already are producing evolutionary trees with much more detail than what we show in the paper," he said. "In fact, we are surprised at our progress so far in our goal of tracing these histories all the way back to the beginning of life."


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Contact: Barbara K. Kennedy
science@psu.edu
818-633-4682
Penn State
Source:Eurekalert  

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