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Scientists develop method to determine order of mutations that lead to cancer
Date:6/30/2011

il they've progressed beyond the initial growth phase. The researchers got around this problem by developing a novel statistical strategy. They integrated measurements of mutations with measurements of structural variations in a genome, which result in the cell having abnormal numbers of copies of one or more sections of DNA. "Now we have an ordering tool that should be broadly useful," Gray said.

So far, the researchers have investigated only a few types of cancer. Going forward, the analysis could be applied to all cancers. One near-term goal, Gray said, is to identify early mutations for which there are therapies already available.


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Contact: Elisa Williams
willieli@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

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