Navigation Links
Scientists develop method to determine order of mutations that lead to cancer
Date:6/30/2011

PORTLAND, Ore. -- Zeroing in on the early cell mutations that enable a cancer to grow is one of the best ways to find a personalized therapy to stop it. Scientists were able to use a statistical approach for the first time to map out the order in which these abnormalities form to analyze the pattern of DNA changes in advanced skin and ovarian tumors.

The study's findings, which are published in the July edition of Cancer Discovery, are the result of a collaboration of scientists at the Oregon Health & Science University Knight Cancer Institute; the Lawrence Berkeley National Laboratory, the University of California, San Francisco; and the Samsung Advanced Institute of Technology.

The researchers focused on assessing mutations involving TP53, a gene that normally prevents cells from becoming cancerous. By examining how additional copies of the mutant gene accumulated, they found that changes in TP53 occurred earlier in the disease's progression than previously believed.

Cancers are the result of multiple mutations, but the ones that happen first set the stage for additional abnormalities.

"We anticipate that this information will enhance our ability to detect cancer early when it is more likely to respond well to treatment," said Joe Gray, Ph.D., associate director for translational research for the OHSU Knight Cancer Institute.

Early mutations are also important because they are found in every cell of the cancer. "By understanding what happens early in a tumor's growth, you can develop therapies that will target all cancer cells," said Paul Spellman, Ph.D., of the Lawrence Berkeley National Laboratory and one of the lead scientists on the study. Spellman will join the OHSU Knight Cancer Institute in July.

Getting information about the order in which aberrations occur previously was difficult because it required the ability to analyze tumors as they developed. But, many cancers aren't detected unt
'/>"/>

Contact: Elisa Williams
willieli@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Page: 1 2

Related biology news :

1. USC scientists uncover mechanism by which chronic stress causes brain disease
2. UCLA stem cell scientists discover new airway stem cell
3. Johns Hopkins scientists expose cancer cells universal dark matter
4. Lithuanian scientists clean up at 2011 EUREKA Innovation Award
5. Scientists a step closer to understanding natural antifreeze molecules
6. Scientists uncover an unhealthy herds hypothesis
7. Qld fruit fly scientists in race against time
8. UC Riverside neuroscientists discovery could bring relief to epilepsy sufferers
9. Scientists breakthrough attracts new funding for high blood pressure research
10. Scientists develop a fatty kryptonite to defeat multidrug-resistant Super bugs
11. Scientists learn how horseweed shrugs off herbicide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... High crime rate, increasing ... access control systems market in Saudi Arabia ... published report by TechSci Research " Saudi Arabia Access Control ... systems market in Saudi Arabia ... control systems market in the Kingdom is growing at ...
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. ... Online (FIDO ® ) Alliance tm , an ... FIDO members commit to share technology and collaborate ... that are interoperable, more secure and private, and ... biometric identity verification that protects sensitive user information ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) has ... - NEC" report to their offering. ... to supply a range of IT security management and ... on the development of a Big Data and cloud ... Asia-Pacific region is a core ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NEC Security Competitive Profile 2015 2
... for ... Irregularities and Obstructions, VILNIUS, Lithuania, June ... recognition technology to the,company,s suite of biometric identification algorithms ... recognition,algorithm that rapidly detects and compensates for partial obstructions,irregularities ...
... AMBER Alert Safety Centers,Inc. announced today that the Company ... Fair, to be held at the Meadowlands Sport,Complex in East ... the entire family featuring rides, free entertainment, games, exhibits,shopping and ... Patterson -- Chief Executive Officer ...
... Museum of Natural Science, or MNS, recently participated in a ... the world. This study the largest study of bird ... avian evolutionary tree, but completely redrawn it. The results of ... MNS, genetic resources collection, will be published in Science ...
Cached Biology News:New VeriEye SDK from Neurotechnology Enables Development of Reliable, Cost-effective Biometric Iris Recognition Systems 2New VeriEye SDK from Neurotechnology Enables Development of Reliable, Cost-effective Biometric Iris Recognition Systems 3AMBER Alert Safety Centers to Provide Child Safety Precautions at the New Jersey State Fair at the Meadowlands 2AMBER Alert Safety Centers to Provide Child Safety Precautions at the New Jersey State Fair at the Meadowlands 3'Early bird' project really gets the worm 2
(Date:5/21/2015)... CA (PRWEB) May 21, 2015 ... has announced a partnership with PicnicHealth, a healthcare ... patients. Participants diagnosed with Inflammatory Bowel Disease (IBD) ... as a complementary uBiome research kit. Both companies ... , For more information on ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Patent Offering, ... method for diagnostic or therapeutic imaging within a body ... uses an endoscope having a low cost, single-use disposable ... filing date was October 18, 2013 and the patent ... technology enables the physician to customize the lighting and ...
(Date:5/21/2015)... 2015 /PRNewswire/ - RepliCel Life Sciences Inc. (TSX.V: ... company focused on the development of autologous cell ... the International Society for Cellular Therapy (ISCT) on ... currently in a Phase 1/2 clinical trial.  The ... from 5:30 PM to 7:00 PM local time, ...
(Date:5/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/x4b7kw/top_technologies ) ... in HW_Technical Insights" report to their offering. ... trends in the Health and Wellness sector and has ... an impact in the year 2015. The research service ... health and wellness technologies that are anticipated to have ...
Breaking Biology Technology:uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Top Technologies in the Health and Wellness Industry 2015 2
... 2011 RadQual, LLC, a premier developer of innovative ... positron emission tomography (PET) imaging, is pleased to ... the National Institute of Standards and Technology (NIST) for ... up to a 1 millicurie (37 MBq) strength.  Fluorine-18 ...
... Feb. 14, 2011 Pharma ChemOutsourcing today launched its ... of 50 speakers from a diverse array of biotechnology ... "The biotechs all have clinical pipelines and their ... human resources demonstrate how they have emerged as the ...
... Chimerix, Inc., a pharmaceutical company developing orally-available broad ... a $45 million Series F financing. New Leaf ... new investors Pappas Ventures and Morningside Group, as ... Alta Partners, Asset Management Company and Frazier Healthcare ...
Cached Biology Technology:RadQual, LLC Announces a New Industry Leading Dose Calibrator Reference Standard 2Pharma ChemOutsourcing 2011 Unveils First Wave of 50 Biotech Chemist Speakers for September 12-15 Show in New Jersey 2Chimerix Completes $45 Million Financing to Fund Further Development of Novel Antiviral Therapeutics CMX001 and CMX157 2Chimerix Completes $45 Million Financing to Fund Further Development of Novel Antiviral Therapeutics CMX001 and CMX157 3Chimerix Completes $45 Million Financing to Fund Further Development of Novel Antiviral Therapeutics CMX001 and CMX157 4
Recombinant Rat CINC-2 beta, CF...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SGG (Sheep gamma globulin) lysine through amide bonds. This product is homologous to NP-BSA....
... boxes are ideal for use in refrigerators, freezers, or ... Four vibrant colors allow for color coding to project, ... nitrogen drainage or promote cool air circulation. Supplied with ... 100 tubes. Box dimensions: 13 x 13 ...
Similar to proteasome (prosome, macropain) 26S subunit, ATPase, 1 Antigen: Recombinant Protein...
Biology Products: