Navigation Links
Scientists develop a new HIV microbicide -- and a way to mass produce it in plants
Date:5/28/2009

In what could be a major pharmaceutical breakthrough, research published online in The FASEB Journal (http://www.fasebj.org) describes how scientists from St George's, University of London have devised a one-two punch to stop HIV. First the report describes a new protein that can kill the virus when used as a microbicide. Then the report shows how it might be possible to manufacture this protein in quantities large enough to make it affordable for people in developing countries.

"We desperately need to control the spread of HIV, particularly in developing countries," said Julian Ma of the Department of Cellular and Molecular Medicine at St. George's and the senior researcher involved in the work. "A vaccine is still some way off, but microbicides could provide a more immediate solution, provided we can overcome major hurdles of high efficacy, low cost, and wide availabilityall of which we address in this study."

In the research paper, Ma and colleagues describe how they combined two protein microbicides (b12 monoclonal antibody and cyanovirin-N) into a single "fusion" molecule and showed that this molecule is more active against HIV than either of its individual components. They designed synthetic DNA for producing this molecule and introduced this DNA into plant cells. After regenerating transgenic plants that produce the fusion molecule, they prepared the microbicide from a plant extract made by grinding the leaves.

"This study is nothing short of a breakthroughnot only does it yield a new drug to fight the spread of HIV, but it also shows us how we can produce it on the scale necessary to get it into the hands of those who need it most," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Unlike their unregulated counterparts in the dietary supplement industry, these scientists are using the engines of nature to manufacture pharmaceuticals that must undergo extens
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. City rats loyal to their hoods, scientists discover
2. Scientists find formula to uncover our planets past and help predict its future
3. Scientists announce top 10 new species, issue SOS
4. Scientists announce top 10 new species; issue SOS
5. Queens scientists discover eco-friendly wood dissolution
6. Stanford scientists find heat-tolerant coral reefs that may resist climate change
7. Scientists work to plug microorganisms into the energy grid
8. Scientists identify worlds largest leatherback turtle population
9. UCSB scientists document fate of huge oil slicks from seeps at coal oil point
10. Scientists urge global action to preserve water supplies for billions worldwide
11. Scientists aim to bring indigenous people into climate change monitoring and policy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... under clinical trials to treat tuberculosis could be the ... against various bacteria, fungal infections and parasites, yet evade ... chemists and collaborators. , Led by U. of I. ... ways the drug SQ109 attacks the tuberculosis bacterium, how ... from yeast to malaria and how targeting multiple ...
(Date:4/17/2014)... study suggests that fish consumption advisories for expecting ... long-lived contaminants like persistent organic pollutants (POPs). ... researchers including University of Toronto Scarborough PhD student ... how different levels of environmental contamination, a mother,s ... in the body influenced exposure in her children. ...
(Date:4/17/2014)... KAN. A Kansas State University engineer has ... and remotely detects improvised explosive devices. The same ... William Dunn, the Steven M. and Kay L. ... mechanical and nuclear engineering, and his research team ... hidden underground or in car trunks. The distance ...
Breaking Biology News(10 mins):Multitarget TB drug could treat other diseases, evade resistance 2Fish consumption advisories fail to cover all types of contaminants 2Patented research remotely detects nitrogen-rich explosives 2
... 1, 2011 JERUSALEM, Israel EUREKA the ... supported by 40 member states and mobilizing more than ... today announced the launch of "E!nnoVest", its new ... This web-based instrument allows investors to identify highly-qualified and ...
... Industrial Revolution, over half of all the CO2 produced by ... pH drop faster than any time in the last 650,000 ... that this causes fish to lose their sense of smell, ... shows that fish hearing is also compromised. Working ...
... beetles march across the forests of western North America, ... a single outbreak. A rise in overall temperatures over ... mountain pine beetles, resulting in an epidemic and possibly ... blight to occur in North America. Dr. Francois ...
Cached Biology News:Ocean acidification leaves clownfish deaf to predators 2Storing seeds for a rainy day -- or in this case, a fire 2
(Date:1/14/2014)... 2014 The largest international professional organization of ... therapeutic derivatives thereof has endorsed an educational program ... the challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural ...
(Date:1/14/2014)... Boston, MA (PRWEB) January 14, 2014 iLab ... Michelle Detwiler as the new Director of Product Strategy. In ... as well as iLab sub-teams to guide in the development ... that iLab provides the maximum possible benefit to the scientific ...
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: ... and commercializing innovative therapies addressing major unmet medical ... received the Notice of Allowance from the United ... self-delivering RNAi compounds (sd-rxRNA®), for the treatment of ...
(Date:1/14/2014)...   Kinaxis ®, provider of RapidResponse ®, a cloud-based ... planning ( S&OP ) service, is proud to be a ... be held at the Hilton San Diego Bayfront, January 30 ... Elisabeth Kaszas , Director of Supply Chain at Amgen, as ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... examination gloves made from U.S.-sourced guayule rubber ... latex allergy, MARICOPA, Ariz., April 24 Yulex ... safe for medical devices, received,510(k) clearance from the U.S. ... device made from guayule, a desert crop native to ...
... England, April 24 The Board of,Directors of ... the global specialty,biopharmaceutical company, announces today that Michael ... Director with immediate effect., Dr Rosenblatt is ... Massachusetts. He was previously Professor of Medicine at ...
... /PRNewswire/ - Aegera Therapeutics Inc. is very,pleased to ... executives to its Board of Directors: Mr. Jeremy ... Limited, and Mr. Gary,Littlejohn, Managing Director of Desjardins ... and networks will be,critical for Aegera as we ...
Cached Biology Technology:FDA Clears First Medical Product Made From Yulex(R) Natural Rubber 2Dr Michael Rosenblatt Appointed Non-Executive Director at Shire 2Dr Michael Rosenblatt Appointed Non-Executive Director at Shire 3Dr Michael Rosenblatt Appointed Non-Executive Director at Shire 4Aegera Therapeutics welcomes two experienced executives to its board of directors 2
... inserts fit into the Universal ... you to greatly increase your ... format plates at an angle, ... the shaker at once for ...
BD FastImmune EDTA Solution. Applications: Flow Cytometry Storage Temperature: Refrigerate(2 to 8C)...
Spaced cover glasses to promote effective hybridization...
prototype Nco I...
Biology Products: