Navigation Links
Scientists develop a new HIV microbicide -- and a way to mass produce it in plants
Date:5/28/2009

In what could be a major pharmaceutical breakthrough, research published online in The FASEB Journal (http://www.fasebj.org) describes how scientists from St George's, University of London have devised a one-two punch to stop HIV. First the report describes a new protein that can kill the virus when used as a microbicide. Then the report shows how it might be possible to manufacture this protein in quantities large enough to make it affordable for people in developing countries.

"We desperately need to control the spread of HIV, particularly in developing countries," said Julian Ma of the Department of Cellular and Molecular Medicine at St. George's and the senior researcher involved in the work. "A vaccine is still some way off, but microbicides could provide a more immediate solution, provided we can overcome major hurdles of high efficacy, low cost, and wide availabilityall of which we address in this study."

In the research paper, Ma and colleagues describe how they combined two protein microbicides (b12 monoclonal antibody and cyanovirin-N) into a single "fusion" molecule and showed that this molecule is more active against HIV than either of its individual components. They designed synthetic DNA for producing this molecule and introduced this DNA into plant cells. After regenerating transgenic plants that produce the fusion molecule, they prepared the microbicide from a plant extract made by grinding the leaves.

"This study is nothing short of a breakthroughnot only does it yield a new drug to fight the spread of HIV, but it also shows us how we can produce it on the scale necessary to get it into the hands of those who need it most," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Unlike their unregulated counterparts in the dietary supplement industry, these scientists are using the engines of nature to manufacture pharmaceuticals that must undergo extensive safety and efficacy testing long before the first gel or cream is administered."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. City rats loyal to their hoods, scientists discover
2. Scientists find formula to uncover our planets past and help predict its future
3. Scientists announce top 10 new species, issue SOS
4. Scientists announce top 10 new species; issue SOS
5. Queens scientists discover eco-friendly wood dissolution
6. Stanford scientists find heat-tolerant coral reefs that may resist climate change
7. Scientists work to plug microorganisms into the energy grid
8. Scientists identify worlds largest leatherback turtle population
9. UCSB scientists document fate of huge oil slicks from seeps at coal oil point
10. Scientists urge global action to preserve water supplies for billions worldwide
11. Scientists aim to bring indigenous people into climate change monitoring and policy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Coffea arabica accounts for ... abiotic factors. During this educational webinar, participants will learn about the importance of ... a better understanding of how genomics is important for coffee breeding improvement. , ...
(Date:8/14/2017)... ... August 14, 2017 , ... The Conference Forum has ... will take place on September 6, 2017 at the Marriott Copley Place in Boston, ... Experimental Medicine, Informatics, and Regulatory Strategy, Pfizer Innovative Research Lab, Pfizer, who leads 19 ...
(Date:8/11/2017)... ... August 11, 2017 , ... ... in particular, more natural alternatives to synthetic ingredients,” said Matt Hundt, President of ... with the established manufacturing presence and know-how of Biorigin will allow us to ...
(Date:8/10/2017)... Durham, NC (PRWEB) , ... August 09, 2017 , ... ... fractures. Almost half never recover well enough to live an independent lifestyle and, even ... , A new discovery by doctors at the University of California Davis Medical ...
Breaking Biology Technology: