Navigation Links
Scientists develop a fatty 'kryptonite' to defeat multidrug-resistant 'Super bugs'

Bethesda, MD "Super bugs," which can cause wide-spread disease and may be resistant to most, if not all, conventional antibiotics, still have their weaknesses. A team of Canadian scientists discovered that specific mixtures of antimicrobial agents presented in lipid (fatty) mixtures can significantly boost the effectiveness of those agents to kill the resistant bacteria. This discovery was published online in The FASEB Journal (

According to a researcher involved in the study, Richard Epand, Ph.D. from the Department of Biochemistry and Biomedical Science at McMaster University in Hamilton, Ontario, Canada, "This study may contribute to overcoming the lethal effects of drug resistant bacteria that is becoming an increasing clinical problem, particularly in hospitals."

To make their discovery, Epand and colleagues conducted experiments using groups of mice infected with lethal doses of multidrug-resistant Escherichia coli (E. coli). Researchers then treated the mice with conventional drug combinations or drug combinations encapsulated in lipid mixtures. They found that certain lipid mixtures caused the drugs to act together in a synergistic manner. In this form, the drugs were much more effective in increasing the survival rate of the mice because they overcame the cellular mechanisms used by these bacteria to defeat therapeutic agents. This study also demonstrated a novel use of a new family of antimicrobial agents called oligo-acyl-lysyls, which have the potential to be combined with other drugs and lipid mixtures with similar properties to yield a platform for other specific applications.

"As we've seen in the recent E.Coli outbreak in Germany, bacteria can mutate to become super bugs that resist antibiotics," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "Thanks to this new, lipid-based antibiotic therapy. multidrug-resistant bacteria may begin to look more like Jimmy Olsen and a lot less like Superman."


Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Related biology news :

1. Scientists learn how horseweed shrugs off herbicide
2. Scientists pitch in to help keep salad mixes safe to eat
3. Top Latin-American scientists named 2011 Pew Fellows in the Biomedical Sciences
4. 22 of Americas most promising scientists selected as 2011 Pew Scholars in the Biomedical Sciences
5. Scientists find deadly amphibian disease in the last disease-free region of central America
6. Social scientists study impact of human adult stem cell research
7. Scripps Research scientists awarded $2.2 million to develop treatment for multi-drug addiction
8. Scientists learn from kids, kids become scientists in new MU effort
9. UCLA scientists identify how major biological sensor in the body works
10. Stanford climate scientists forecast permanently hotter summers
11. Scientists uncover role for cell scaffold in tumor formation
Post Your Comments:
(Date:4/15/2016)... April 15, 2016 Research ... Gait Biometrics Market 2016-2020,"  report to their offering.  ... ) , ,The global gait biometrics market is ... during the period 2016-2020. Gait analysis ... can be used to compute factors that are ...
(Date:3/31/2016)... Florida , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange ... potential users of its soon to be launched online ... ( ) will also provide potential ... use of DNA technology to an industry that is ...
(Date:3/23/2016)... , March 23, 2016 ... Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung mit ... Inc. (NASDAQ: MESG ), ein ... dass das Unternehmen mit SpeechPro zusammenarbeitet, um ... der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the ... at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application ... team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
(Date:6/23/2016)... Connecticut (PRWEB) , ... June 23, 2016 , ... ... introduce a new line of intelligent tools designed, tuned and optimized exclusively for ... September 12–17 in Chicago. The result of a collaboration among several companies with ...
Breaking Biology Technology: