Navigation Links
Scientists determine drug target for the most potent botulinum neurotoxin
Date:4/29/2008

UPTON, NY Botulinum neurotoxin responsible for the deadly food poisoning disease botulism and for the beneficial effects of smoothing out facial wrinkles can also be used as a dreaded biological weapon. When ingested or inhaled, less than a billionth of an ounce can cause muscle paralysis and eventual death. Although experimental vaccines administered prior to exposure can inhibit the destructive action of this neurotoxin the most deadly protein known to humans no effective pharmacological treatment exists.

Now, scientists at the U.S. Department of Energys Brookhaven National Laboratory and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) have taken the first step toward designing an effective antidote to the most potent form of the toxin. They have found that they can trick the toxin to bypass its normal binding protein, thereby blocking its deadly action. The results of their research are reported in the April 22, 2008 online issue of the Journal of Biological Chemistry.

We have found a highly efficient inhibitor of botulinum neurotoxin type A the most potent of seven neurotoxins produced by the bacterium Clostridium botulinum. This finding can lead to a very effective drug to stop the devastating effects of the toxin, said Brookhaven Lab biologist Subramanyam Swaminathan, the studys co-principal investigator. We intend to do further research to tailor the inhibitor for the best results.

We are excited about the success of this work and the prospects it holds for future drug development, said USAMRIID principal investigator S. Ashraf Ahmed, who initiated the structure-based inhibitor design as part of the Institutes bio-defense research program.

To cause its deadly effects, the botulinum neurotoxin first binds to a nerve cell membrane, which curves inward, incorporating the toxin into a vesicle that drifts inside the cell. The toxin eventually travels from the vesicle to the cytosol, the int
'/>"/>

Contact: Diane Greenberg
greenb@bnl.gov
631-344-2347
DOE/Brookhaven National Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists make chemical cousin of DNA for use as new nanotechnology building block
2. Scientists find stem cells for the first time in the pituitary
3. Brown scientists say biodiversity is crucial to ecosystem productivity
4. Scientists urged to make a stand on climate change
5. Scientists clarify a mechanism of epigenetic inheritance
6. Scientists to explore global change-public health connection
7. Scientists test device to track medication adherence in patients with HIV/AIDS
8. Scientists discover how nanocluster contaminants increase risk of spreading
9. Smithsonian scientists find evidence that could rewrite Hawaiis botanical history
10. Argonne scientists develop techniques for creating molecular movies
11. Scientists debate the accuracy of Al Gores documentary An Inconvenient Truth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... in German . ... drugs. When treating overdoses, doctors are often limited to supportive ... there is a combination of drugs involved. So what can ... his grandmother,s pills? ETH professor Jean-Christophe Leroux from the Institute ... answer to this question. "The task was to develop an ...
(Date:10/16/2014)... cultivated efficiently, they are anything but sustainable: environmental ... cultivation is becoming increasingly evident. Despite their disadvantages, ... are regarded as the sole possibility of achieving ... finds Bernhard Schmid, an ecology professor at the ... of agriculture and forestry. After all, a new ...
(Date:10/15/2014)... our ability to assess the pandemic risk from strains ... we must not allow ourselves to become complacent that ... international consortium of scientists. , Influenza pandemics arise when ... yet to develop widespread immunity – spreads in the ... the past 100 years, the worst of which – ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
... The 2010 Annual Meeting & OTO EXPO of the American ... the largest meeting of ear, nose, and throat doctors in ... official abstract supplement for the annual meeting is now available ... Otolaryngology Head and Neck Surgery . (See new ...
... a genetic route to understanding and treating epilepsy. Timothy ... has identified an ancient gene family that plays a role ... "In healthy people, nerves do not fire excessively in response ... on what really matters. Nerve cells maintain a threshold ...
... Eliza Hall Institute researchers in Melbourne, Australia, have made ... cell death and its role in tumour formation. ... process in human biology as it removes unwanted and ... against cancer development and autoimmune disease. The ...
Cached Biology News:Otolaryngology -- Head and Neck Surgery Annual Meeting supplement now available 2Epileptic seizures may be linked to an ancient gene family 2Missing Puma reveals cancer conundrum 2Missing Puma reveals cancer conundrum 3
(Date:10/18/2014)... (PRWEB) October 19, 2014 The ... (Short Acting, Intermediate Acting, Premixed), Modern Human Insulin ... Apidra, Levemir, NovoRapid, Novomix, Tresiba, Others) - Forecast ... major drivers, restraints, challenges, opportunities, current market trends, ... along with the estimates and forecasts of the ...
(Date:10/18/2014)... The Asian arthroscopic devices report defines and segments the ... revenue. The arthroscopic devices market in Asia is estimated ... CAGR of 6.5% from 2013 to 2018. , Browse ... to get an idea of the in-depth analysis provided. ... arthroscopic devices market in the same region, and is ...
(Date:10/18/2014)... The Asian Electronic Medical Record (EMR) market ... analysis and forecast of revenue. The electronic medical record market ... million by 2018, at a CAGR of 9.4% from 2013 ... Electronic Medical Record (EMR) market, to get an idea of ... the segmentation of the market in the same region, and ...
(Date:10/18/2014)... The report " Cloud Analytics ... Web; Speech; Machine; Video; Predictive Analytics: Global Advancements, ... & Analysis (2013 - 2018) ", defines and ... sub segments with an in-depth analysis and forecasting ... factors driving this market, various restraints, and opportunities ...
Breaking Biology Technology:Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5
... in ... ... CHDX ) a leading independent American provider of Western,healthcare services ... has agreed to an investment by JPMorgan,s Principal,Investment Management group. The ...
... Nov. 7 Transgenomic Inc. (OTC,Bulletin Board: TBIO) announces the following Webcast: ... Conference Call, ... Where: http://www.transgenomic.com/events.asp?id=6 , How: ... at the ...
... - Nventa,Biopharmaceuticals Corporation (TSX: NVN) announced today financial results,for ... unless,specified otherwise, are in Canadian dollars. Nventa reported ... share, for the,three months ended September 30, 2007, compared ... share, for the same period in 2006. For the ...
Cached Biology Technology:JPMorgan's Principal Investment Management Group to Invest in Chindex International, Inc. 2JPMorgan's Principal Investment Management Group to Invest in Chindex International, Inc. 3Webcast Alert: Transgenomic Inc. Announces Third Quarter 2007 Earnings Release Conference Call Webcast 2Nventa Biopharmaceuticals Corporation announces third-quarter 2007 financial results 2Nventa Biopharmaceuticals Corporation announces third-quarter 2007 financial results 3Nventa Biopharmaceuticals Corporation announces third-quarter 2007 financial results 4
... (ELISA) test kits are qualitative one-step kits ... of drugs and/or their metabolites in forensic ... use only. It is recommended that all ... method such as GC/MS. The simple ...
96 Well Base Plate...
... a recombinant human protein produced in E. coli ... RNase A type enzymes. The mode of ... in a 1:1 ratio. The enzyme has been ... and cell types. Addition of the ribonuclease inhibitor ...
... Inkjet Printer) is a revolutionary new ... Protein Macroarray Analysis, developed in conjunction ... strategy compliments established protocols in resolving ... proteins isoelectric point and apparent molecular ...
Biology Products: