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Scientists deconstruct cell division
Date:2/8/2009

g, she and colleagues have now isolated the spindle matrix. Interestingly, both dynein and Nudel are components of the spindle matrix. Nudel binds to lamin-B and brings it to microtubules where both Nudel and dynein then help the lamin-B assemble into the spindle matrix. The lamin-B-containing spindle matrix, in turn, works with microtubules to orchestrate spindle assembly and cell division.

"Isolating the spindle matrix and identifying its components has also allowed us to show that the matrix contains not only factors important for spindle assembly, but also proteins essential for cell fate choices," remarked Zheng. "We believe that by understanding how the spindle matrix is assembled in mitosis, it will be possible to understand how, after mitosis, two daughters can chose to become the same or different cell typesa decision that cells need to make both during the development of an organism and during the maintenance of adult tissues."


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Contact: Yixian Zheng
zheng@ciwemb.edu
410-246-3032
Carnegie Institution
Source:Eurekalert  

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