Navigation Links
Scientists deconstruct cell division
Date:2/8/2009

Baltimore, MDThe last step of the cell cycle is the brief but spectacularly dynamic and complicated mitosis phase, which leads to the duplication of one mother cell into two daughter cells. In mitosis, the chromosomes condense and the nucleus breaks down. Fibrous structures called spindles form, which then move the chromosomal material toward opposite ends of a cell and help partition other cell contents. If something goes wrong, diseases such as cancer can arise. Scientists have tried for years to unravel the process of spindle assembly. Now, researchers at Carnegie's Department of Embryology have found that two proteins dynein and Nudelinvolved in other cell-division functions, are essential to regulate assembly of the spindle matrix.

"The mechanisms that cells use during division to partition both chromosomes and regulatory factors into their daughters are widely recognized as among the most fundamental processes in all of biology. During the last several years no one has done more than Yixian Zheng to broaden our understanding of how dividing cells control these critical events," said Allan Spradling, Department of Embryology director.

"To ensure proper cell division, the mother cell needs to separate its genetic materials, the chromosomes, equally, but also partition its cellular content properly into daughter cells," explained co-author Yixan Zheng. "Cell division allows a fertilized egg to develop into multicellular organisms with different types of cells. It also replenishes adult tissues, such as skin and bones. Forming a spindle requires the assembly of a 'skeleton' from tube-like microtubules and the construction of a poorly defined scaffold called a spindle matrix."

In 2006, Zheng and colleagues discovered that a protein found in the nucleus during the interphase of the cell division cycle, called lamin-B, is a structural component of the spindle matrix (Science 31 March 2006, 311: 1887-1893). Based on this finding, she and colleagues have now isolated the spindle matrix. Interestingly, both dynein and Nudel are components of the spindle matrix. Nudel binds to lamin-B and brings it to microtubules where both Nudel and dynein then help the lamin-B assemble into the spindle matrix. The lamin-B-containing spindle matrix, in turn, works with microtubules to orchestrate spindle assembly and cell division.

"Isolating the spindle matrix and identifying its components has also allowed us to show that the matrix contains not only factors important for spindle assembly, but also proteins essential for cell fate choices," remarked Zheng. "We believe that by understanding how the spindle matrix is assembled in mitosis, it will be possible to understand how, after mitosis, two daughters can chose to become the same or different cell typesa decision that cells need to make both during the development of an organism and during the maintenance of adult tissues."


'/>"/>

Contact: Yixian Zheng
zheng@ciwemb.edu
410-246-3032
Carnegie Institution
Source:Eurekalert  

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists deconstruct cell division
(Date:5/3/2016)... May 3, 2016  Neurotechnology, a provider of ... MegaMatcher Automated Biometric Identification System (ABIS) , a ... projects. MegaMatcher ABIS can process multiple complex biometric ... combination of fingerprint, face or iris biometrics. It ... and MegaMatcher Accelerator , which have ...
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
(Date:6/23/2016)... 23, 2016 On Wednesday, June 22, ... down 0.22%; the Dow Jones Industrial Average edged 0.27% lower ... 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on the following ... Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... a new line of intelligent tools designed, tuned and optimized exclusively for Okuma ... 12–17 in Chicago. The result of a collaboration among several companies with expertise ...
(Date:6/22/2016)... DIEGO , June 22, 2016 ... that will allow them to produce up to ... from one lot within one week. These high-quality, ... time laboriously preparing cells and spend more time ... possible through a proprietary, high-volume manufacturing process that ...
Breaking Biology Technology: