Navigation Links
Scientists decode genomes of diverse TB isolates
Date:11/21/2007

jects principal investigators and a leading researcher of the XDR epidemic in KwaZulu-Natal, dean of the Nelson Mandela School of Medicine, and director of the MRC Genital Ulcer Disease Research Unit at the University of KwaZulu-Natal. Genetic characterization of this strain is essential for developing tools to get this epidemic under control.

Globally, tuberculosis (TB) is a major cause of infectious disease deaths. Nearly 2 billion people, comprising roughly one third of the worlds population, are thought to carry M. tuberculosis, the culprit bacterium. Major obstacles to controlling the disease stem from the microbes ability to evade current treatments, which typically require prolonged use by patients and are often not curative. MDR strains, for example, are resistant to two of the most effective first-line TB drugs, and XDR strains can circumvent first-line as well as some second-line drugs. Adding to the problem, inefficient diagnostic methods for TB make it difficult for doctors to determine whether an individual harbors a drug-resistant strain, often delaying proper therapy.

To shed light on the genetic changes that mediate drug resistance, an international team of scientists undertook a large-scale effort to sequence the genomes of drug sensitive, MDR, and XDR TB isolates of a strain responsible for the current XDR-TB epidemic in KwaZulu-Natal, South Africa. This strain corresponds to one found in patients in Tugela Ferry, a rural town in KwaZulu-Natal that has recently experienced a severe outbreak of XDR TB among patients infected with the human immunodeficiency virus (HIV). There, 52 of 53 people infected with this strain died. The research reflects a collaboration among researchers in the Microbial Sequencing Center at the Broad Institute of Harvard and MIT, Megan Murray of the Harvard School of Public Health, and Willem Sturm and his colleagues at the Nelson Mandela Medical School in South Africa.

The draft genome sequences
'/>"/>

Contact: Robin Herman
rherman@hsph.harvard.edu
617-432-4752
Harvard School of Public Health
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... developed a novel and versatile modeling strategy to simulate ... materials as well as for studying polyelectrolytes, including DNA ... model much larger and more complex polyelectrolyte systems, and ... lead author of a paper on the work and ... Science and Engineering. "This is a big step forward ...
(Date:8/20/2014)... ITHACA, N.Y. In a study of 158 pregnant ... the craving and intentional consumption of ice, cornstarch, ... items, reports a new Cornell study. , Moreover, such ... teens who did not eat nonfood substances. , Pregnant ... low hemoglobin, which can lead to iron deficiency and ...
(Date:8/20/2014)... Issue Serious allergic reactions to food ... for some children.    What you should know ... allergies and this number may be increasing, especially among children. ... have food allergies.  The symptoms of allergic ... breathing difficulties and loss of consciousness. Symptoms can also develop ...
Breaking Biology News(10 mins):Researchers develop models to study polyelectrolytes, including DNA and RNA 2Pica in pregnant teens linked to low iron 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... Spanish . , The potentially deadly yellow-fever-transmitting ... a compound called octenol as one way to find a ... scientists report. Scientists have long known that mosquitoes can ... Joseph Dickens and Jonathan Bohbot explains in greater detail how ...
... American Institute of Biological Sciences (AIBS) has selected Meredith ... Davis, Ryan Richards, a graduate student at the University ... student at the University of Rhode Island, to receive ... "AIBS is committed to fostering a productive ...
... Spring Harbor, NY -- One seemingly insurmountable obstacle to the ... wheat and rice is the dependence of those plants on ... and egg -- combine randomly to generate a genetically unique ... But what if plants like these could be engineered ...
Cached Biology News:ARS study provides a better understanding of how mosquitoes find a host 2AIBS names emerging public policy leaders 2AIBS names emerging public policy leaders 3CSHL-Mexican team coaxes sexually reproducing plant to brink of asexual reproduction 2
(Date:8/21/2014)... On Wednesday of last week RENU 28, the world's ... became available for purchase in Australia and New Zealand, and ... 28 works is, if you think about the definition of ... cellular renewal within your body. If you think about the ... cellular renewal. What RENU 28 does is it works with ...
(Date:8/20/2014)... the first time, chemists have succeeded in measuring vibrational ... resolution. The study reveals how vibration of a single ... , The study was performed at the University ... the University of Jyvskyl works as a visiting fellow ... the study. The second team was lead by Professor ...
(Date:8/20/2014)... International Corporation (NASDAQ: PRXL ) announced today ... Conference in New York.  Ingo Bank , Senior ... a presentation on PAREXEL and discussing business developments at ... A live webcast of the discussion will be ... www.PAREXEL.com in the Upcoming Events portion of ...
(Date:8/20/2014)... health of your heart, researchers have discovered. , A ... TENS machine like those designed to relieve labour pains ... raised flap at the front of the ear immediately ... changed the influence of the nervous system on the ... failing hearts too hard. , Professor Jim Deuchars, Professor ...
Breaking Biology Technology:RENU 28 Skin Care Now Available in Australia and New Zealand 2Seeing a molecule breathe 2PAREXEL International To Present At Baird Healthcare Conference 2'Tickling' your ear could be good for your heart 2
... 14, 2012 AMPAC Fine Chemicals LLC (AFC), a ... APFC ), reports that it has joined Rx-360 ... biotech industry consortium that was founded by industry leaders ... and to assure the quality and authenticity of the ...
... 2012 Neuralstem, Inc. (NYSE Amex: CUR ) ... registered direct placement of 5,200,000 shares of common stock at ... with an exercise price of $1.02 per share and exercisable ... of five years. The company received aggregate gross proceeds of ...
... Ill., Feb. 13, 2012 Hospira, Inc.  (NYSE: ... injectable drugs and infusion technologies, today announced the hiring ... and compliance capabilities, including the appointment of Zena G. ... 2012. In this role, Ms. Kaufman will have overall ...
Cached Biology Technology:AMPAC Fine Chemicals Continues to Invest in Quality Systems 2AMPAC Fine Chemicals Continues to Invest in Quality Systems 3Neuralstem Announces Closing of $5.2-Million Registered Direct Offering 2Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 2Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 3Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 4Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 5
... Ligase catalyzes the formation of a phosphodiester ... in nicked duplex DNA molecules or between ... complementary strand at 45 - 65?. Tfi ... much higher temperatures than conventional DNA ligases, ...
... a unique β-agarose digesting enzyme developed at ... DNA and RNA from low melting point ... TBE, MOPS, or phosphate buffers. The gel ... TBE, MOPS, and phosphate electrophoresis buffers or ...
... Perhaps sheer in-house demand is causing shortages ... precious antibody. This can cause unwanted distractions, ... Receive royalties for your hard work ... let us build it up,and market it ...
... PBL's bioassays for interferons are cytopathic effect ... assays. Sample types include; tissue culture supernatents; ... In these assays, one unit is defined as ... reduce the cytopathic effect of viral infection by ...
Biology Products: