Navigation Links
Scientists decipher cellular 'roadmap' of disease-related proteins
Date:7/7/2013

University of Toronto researchers are helping demystify an important class of proteins associated with disease, a discovery that could lead to better treatments for cancer, cystic fibrosis and many other conditions.

Igor Stagljar, Professor in the Faculty of Medicine's Donnelly Centre for Cellular and Biomolecular Research, and his team developed the first roadmap for ATP-binding cassette (ABC) transporter proteins. These proteins are crucial components of every cell, and are also involved in tumor resistance.

Scientists have struggled with understanding how ABC transporter proteins work and communicate with other proteins. Stagljar and his team, including first author Dr. Jamie Snider, have solved the mystery by using Membrane Yeast Two-Hybrid ('MYTH') technology to see how these transporter proteins interact with other vital components in the cell.

"Cell systems are complex and we need to have a solid grasp of how the individual pieces fit together in order to understand why certain diseases occur and how to best treat them," says Stagljar, who is also cross-appointed to the Departments of Biochemistry and Molecular Genetics.

ABC transporter proteins act as cellular gatekeepers by retaining nutrients and expelling toxins from the cell. If these proteins are not working properly, it can cause a number of diseases including: cystic fibrosis, age-related macular degeneration, Tangier disease, and Dubin-Johnson syndrome. ABC proteins can also cause cancer cells to reject chemotherapy drugs which makes treatment less effective.

"Our discovery shows how ABC transporter proteins effect cancer and other diseases, and this knowledge can help us develop better, more targeted drugs. This is truly momentous," said Stagljar.

The study was published today in Nature Chemical Biology.


'/>"/>
Contact: Suniya Kukaswadia
suniya.kukaswadia@utoronto.ca
416-978-7752
University of Toronto
Source:Eurekalert

Page: 1

Related biology news :

1. Scientists discover ethnic differences in immune response to TB bacterium
2. Scientists identify promising antiviral compounds
3. Harvard and USC scientists show how DHA resolves inflammation
4. Tiny nanocubes help scientists tell left from right
5. Scientists discover thriving colonies of microbes in ocean plastisphere
6. Scientists discover new details about rice blast, a deadly plant fungus
7. Research reveals low exposure of excellent work by female scientists
8. Scientists use DNA from a museum specimen to study rarely observed type of killer whale
9. Hundreds of insect scientists migrating to Rapid City this week
10. Scientists identify potential drug target for treatment-resistant anemias
11. Carnegie Mellon neuroscientists discover new phase of synaptic development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
(Date:4/18/2017)... Inc., a global expert in SoC-based imaging and computing solutions, has ... features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® ... be showcased during the upcoming Medtec Japan at Tokyo Big Sight ... Las Vegas Convention Center April 24-27. ... Click here for an image of the ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... ... (PRWEB) September 21, 2017 , ... ... scientific and technical congress to review the latest knowledge on these products, which ... international speakers will discuss the impact of Biostimulants on Plant Nutrition, Abiotic Stresses, ...
(Date:9/21/2017)... ... September 21, 2017 , ... Today, BioPharma Institute, a leading ... addition of 5 new courses to its prospectus. These include the eagerly-awaited ... Part 11 on Electronic Records and Electronic Signatures (Part 11 of Title 21 ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... the election of Paul Hermes, Entrepreneur in Residence at Medtronic, Inc., to serve ... developed a proprietary, tissue-engineered scaffold for anterior cruciate ligament (ACL) reconstruction that is ...
(Date:9/20/2017)... ... September 20, 2017 , ... Diversity focused business accelerator, The Refinery ... pitch competition to uncover the top technology-driven, women-led startups in Boston, MA, New Haven/Hamden, ... each city’s entrepreneurial events going on that week – in Boston, it will be ...
Breaking Biology Technology: