Navigation Links
Scientists crack code of critical bacterial defense mechanism
Date:4/25/2010

so completed one additional step to define yet another protein's role.

Wzy connected the five-sugar chains, but it did so with no defined limit to the number of five-sugar units involved, a feature that does not match the natural process. On an actual bacterial cell wall, the length of the polysaccharide falls within a relatively narrow range of the number of chains connected.

So the scientists introduced another protein, called Wzz, to the mixture. This protein is known as a "chain length regulator." With this protein in the mix, the lengths of the resulting polysaccharides were confined to a much more narrow range.

"We were able to replicate the exact polysaccharide biosynthetic pathway in vitro, getting the correct lengths," Woodward said. "This is important because now you can begin to look at a whole host of other properties in the system."

The group already started trying to answer one compelling question: whether the two proteins, Wzy and Wzz, have to interact to fully achieve formation of the polysaccharide.

"We've shown in some preliminary results that they do interact, but we haven't determined whether that interaction has any functional relevance," Woodward said.

With this knowledge in hand, researchers now have access to information about how all three parts of the lipopolysaccharide, the large biomolecule on Gram-negative bacteria cell surfaces, is formed. One thing they already knew is that the entire process takes place on an inner membrane and is then exported to the outer membrane on the cell surface.

Now that scientists can reproduce formation of the lipopolysaccharide, they can more directly characterize the export process a step in the pathway that serves as another potential antibiotic target, Woodward noted.


'/>"/>

Contact: Robert Woodward
woodward.69@osu.edu
614-292-8704
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists discover key step for regulating embryonic development
2. Scientists sever molecular signals that prolific parasite uses to puppeteer cells
3. Scientists create artificial human skin with biomechanical properties using tissue engineering
4. Brown scientists elected to American Academy of Arts and Sciences
5. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
6. 2 Hopkins scientists awarded European honorary doctorates
7. Chinese scientists discover marker indicating the developmental potential of stem cells
8. Scientists find new genes for cancer, other diseases in plants, yeast and worms
9. Scripps Research scientists solve mystery of fragile stem cells
10. Ontario Cancer Institute, US scientists discover compound that kills lymphoma cells
11. UTHealth stem cell scientists explore treatments for blood disorders and lung diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... June 27, 2014  The American Academy of ... of Standards and Technology (NIST) and the Department ... research and forensic science expert members to the ... an element of the NIST,s Organization of Scientific ... the first appointments made to the new FSSB ...
(Date:7/10/2014)... , July 2, 2014  Unisys Corporation,s (NYSE: ... , Unisys Nederland N.V., today announced that it has been ... implement and manage a new Basic Provision Biometrics solution for ... Unisys won the contract with a solution based on ... software. The term of the contract is up to seven ...
(Date:7/10/2014)... , July 3, 2014 Research ... addition of the "Global Gesture Recognition & ... - Forecasts to 2020" report to their ... Global Gesture Recognition & Touch-Less Sensing Market ... around for a while, but the companies were ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2
... is "Molecule of the Year 2009". This was announced ... Society for Molecular and Cell Biology and Biotechnology Protocols ... Zsuzsanna Izsvk, Dr. Zoltn Ivics and Dr. Lajos Mts ... Berlin-Buch. According to the jury, it was selected out ...
... current controversy over vertebroplastya minimally invasive treatment performed ... vertebral compression fractures that fail to respond to ... your medical team to decide if you are ... experience of hundreds of thousands of other patients ...
... BOSTON (January 19, 2010, 12:00 noon EST) A study ... School of Graduate Biomedical Sciences at Tufts, and Tufts Medical ... cancer. The researchers propose a new model for breast cell ... which appears to be the cell of origin for luminal-like ...
Cached Biology News:'Sleeping Beauty' -- Molecule of the Year 2Society of Interventional Radiology supports treatment for spine fractures: Patient selection key 2Society of Interventional Radiology supports treatment for spine fractures: Patient selection key 3Society of Interventional Radiology supports treatment for spine fractures: Patient selection key 4Cell of origin identified for common type of breast cancer 2
(Date:7/10/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, ... report to their offering. ... photonic integration traces its roots in the latter ... photonic integration went unexplored and unfulfilled for several ...
(Date:7/10/2014)... microscopic polymer light resonators that expand in the ... Photonics Laboratory have developed new optical sensors with ... sensors are ideal for detecting trace gas concentrations ... nature, and immunity to electromagnetic interference. , Although ... the MIT team conceived an extremely sensitive, compact ...
(Date:7/10/2014)... The lithium-ion batteries that power our laptops and electric ... a single charge with the help of a sponge-like ... to replace the graphite traditionally used in one of ... times the energy storage capacity of graphite. A paper ... was published today in Nature Communications . , ...
(Date:7/10/2014)... new alliance will see the two universities and NPL ... with business and industry and their complementary academic strengths., ... help to shape the scientific priorities of the UK. ... up to 300 high-calibre PhD students, will provide a ... NPL, the potential of the Laboratory will be grown ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3
... DURHAM, N.C., Dec. 16 Parion Sciences, Inc., ... from the failure of the body,s mucosal defenses, ... have awarded the,company a biodefense grant in excess ... The purpose of the grant is to ...
... KRAS Biomarker PresentsPotential toPersonalize Colorectal Cancer Treatment Determining Who ... , THOUSAND OAKS, Calif., Dec. 16 Amgen ... discuss the clinical utility of the KRAS ... colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor ...
... 16 , - ... The American Journal of Medicine (AJM), one of ... Medicine blog,( http://amjmed.blogspot.com ), a dynamic forum where physicians and ... that have been published in the Journal. , ...
Cached Biology Technology:Parion Sciences Receives NIH Biodefense Grant to Study Novel Methods for Mitigating Radiation-Induced Lung Injury 2Parion Sciences Receives NIH Biodefense Grant to Study Novel Methods for Mitigating Radiation-Induced Lung Injury 3Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 2Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 3Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 4Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 5Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 6Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 7Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 8Elsevier Introduces The American Journal of Medicine Blog 2Elsevier Introduces The American Journal of Medicine Blog 3
... is the major proteolytic system in ... it catalyzes the selective degradation of ... elimination of proteins with abnormal conformation ... The critical protease in this pathway ...
... [1320] to RFC1 Immunogen Recombinant protein ... Factor C expressed in E. coli. Reactivity ... cerevisiae. Not yet tested in other species. This ... Background Information Replication factor C is ...
... Bacterial DNA Isolation Kit provides a rapid ... genomic DNA from the various bacterial species ... the isolation of genomic DNA from both ... milk samples. ,Purification is based on ...
... Chemicon Select Tissue Arrays are intended for ... tissues were fixed in neutral buffered formalin ... and diagnosis was performed by certified pathologists. ... paraffin blocks and relocated into a new ...
Biology Products: