Navigation Links
Scientists crack code of critical bacterial defense mechanism
Date:4/25/2010

COLUMBUS, Ohio Scientists have combined chemistry and biology research techniques to explain how certain bacteria grow structures on their surfaces that allow them to simultaneously cause illness and protect themselves from the body's defenses.

The researchers are the first to reproduce a specific component of this natural process in a test tube an essential step to fully understanding how these structures grow.

With the new method described, these and other researchers now can delve even deeper into the various interactions that must occur for these structures called lipopolysaccharides to form, potentially discovering new antibiotic targets along the way.

Lipopolysaccharides are composed primarily of polysaccharides strings of sugars that are attached to bacterial cell surfaces. They help bacteria hide from the immune system and also serve as identifiers of a given type of bacteria, making them attractive targets for drugs. But before a drug can be designed to inhibit their growth, scientists must first understand how polysaccharides are developed in the first place.

"We were able to answer some of the questions about how components of this growth system do their jobs. This will allow us to more fully characterize lipopolysaccharide biosynthesis in vitro, a process which may shed light on useful targets for developing antibiotic agents," said Robert Woodward, a graduate student in chemistry at Ohio State University and lead author of the study.

The study is published in the April 25 online edition of the journal Nature Chemical Biology.

The researchers used a harmless strain of Escherichia coli as a model for this work, which would apply to other E. coli strains and similar Gram-negative bacteria, a reference to how their cell walls are structured.

The surface of these bacteria house the lipopolysaccharide, which is a three-part molecular structure embedded into the cell membrane. Tw
'/>"/>

Contact: Robert Woodward
woodward.69@osu.edu
614-292-8704
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists discover key step for regulating embryonic development
2. Scientists sever molecular signals that prolific parasite uses to puppeteer cells
3. Scientists create artificial human skin with biomechanical properties using tissue engineering
4. Brown scientists elected to American Academy of Arts and Sciences
5. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
6. 2 Hopkins scientists awarded European honorary doctorates
7. Chinese scientists discover marker indicating the developmental potential of stem cells
8. Scientists find new genes for cancer, other diseases in plants, yeast and worms
9. Scripps Research scientists solve mystery of fragile stem cells
10. Ontario Cancer Institute, US scientists discover compound that kills lymphoma cells
11. UTHealth stem cell scientists explore treatments for blood disorders and lung diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2015)... PUNE, India , August 26, 2015 ... (Two, Three, Four, and Five Factor), Application (Travel & ... and Geography - Global Forecast to 2020", published by ... 9.60 Billion by 2020, growing at a CAGR of ... 71 Tables and 82 F igures spread through ...
(Date:8/24/2015)... 24, 2015 The consulting company Frost ... biometrics manufacturer DERMALOG and its customized solutions and products for ... Company of the Year Award". DERMALOG is particularly successful with ...   -Cross reference: Picture is available at AP ... On Thursday evening, in South Africa,s ...
(Date:8/20/2015)... Aug. 20, 2015 The wearable technology ... are active and healthy. However, wearable technology has ... environment to help improve diagnostic capabilities and therapeutic ... the Wearable Technologies Conference 2015 , where ... for wearables in healthcare.    "Over ...
Breaking Biology News(10 mins):Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3
... submicroscopic aberration in a particular region of human ... a variety of developmental disorders in children. The ... moderate mental retardation, growth retardation, learning disabilities, seizures, ... head size, unusual facial features, hand deformities, or ...
... speakers and panelists from the U.S. Centers for Disease ... AIDS Institute, and the Semel Institute for Neuroscience and ... which genetics, race and health care disparities prevent or ... the UCLA AIDS Institute, will include a press conference ...
... set of stripy legs in a camera trap photo snapped ... researchers from the Wildlife Conservation Society. The legs belong to ... Democratic Republic of Congo,s Virunga National Park, despite over a ... is the first time this species has been captured on ...
Cached Biology News:Aberrations in region of chromosome 1q21.1 associated with broad range of disorders in children 2Aberrations in region of chromosome 1q21.1 associated with broad range of disorders in children 3Photo reveals rare okapi survived poaching onslaught 2
(Date:8/27/2015)... ... 27, 2015 , ... Capital Edge Consulting , a nationwide consulting firm ... announce their ranking as one of the top 5000 companies listed on the ... the nation. , “It is truly an honor to be recognized as one of ...
(Date:8/27/2015)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced ... 2015. Biorem,s complete second quarter financial statements and MD&A have been ... except earnings per shareThree-months ended , Six -months endedJune 30 , ... , 2014 Revenue , 4,709 , ... , 1,656 , 56 , 3,188 ...
(Date:8/27/2015)... Aug. 27, 2015 In response to ... UPS and The US Postal Service to no ... as ,select agents, by the CDC, Marken reaffirmed ... these sensitive shipments. Marken uses its ... trained and certified personnel to ensure the safe ...
(Date:8/26/2015)... ... August 26, 2015 , ... Lee Biosolutions, a ... development and manufacture of highly valued cardiac markers used in early detection of ... with protein chemistry has led to the development and commercialization of important cardiac ...
Breaking Biology Technology:Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2
... Milestone System; Braden River Equine Begins Next 1,000 Eklin DR Systems ... ... and LAKE SUCCESS, N.Y., Sept. 18 ,Digital radiography (DR) has been ... systems installed throughout,the world. Eklin Medical Systems, a global leader in ...
... Tengion Neo-Bladder Augment(TM) Featured in ... September Issue of Regenerative Medicine, EAST ... regenerative medicine company focused on the development of,neo-organs and ... study conducted with its Tengion Neo-Bladder,Augment(TM) were published in ...
... 18 More than 60 physicians credentialed,to practice at ... were honored by D Magazine at its annual Best ... of the premier specialty surgical,hospitals in the country and ... of,our physicians again included in this prestigious list. The ...
Cached Biology Technology:Eklin Medical Surpasses 1,000th RapidStudy(R) Digital Radiography System Installation Featuring Canon DR Technology 2Eklin Medical Surpasses 1,000th RapidStudy(R) Digital Radiography System Installation Featuring Canon DR Technology 3Eklin Medical Surpasses 1,000th RapidStudy(R) Digital Radiography System Installation Featuring Canon DR Technology 4Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation 2Annual List of 'Best Doctors in Dallas' Showcases Texas Institute for Surgery Physicians 2
... are ideal for storage and transport of ... racks withstand extreme temperatures, making them an ... also be autoclaved for use in sterile ... accommodates 0.5ml microcentrifuge tubes, the other 1.5ml ...
... Signet offers the most comprehensive, ... requirements. We have incorporated unprecedented quality ... capabilities. This includes proven detection chemistries ... to the TechMate protocol. It also ...
... of universal lysis buffer, PCR mix, DNA ... 25 l volume PCR reactions. This system ... or positive rod and coccus bacteria, such ... Staphylococcus Aureus, Streptococcus Agalactiae, and etc. With ...
...
Biology Products: