Navigation Links
Scientists copy the ways viruses deliver genes
Date:8/11/2011

Scientists at the National Physical Laboratory (NPL) have mimicked the ways viruses infect human cells and deliver their genetic material. The research hopes to apply the approach to gene therapy a therapeutic strategy to correct defective genes such as those that cause cancer.

Gene therapy is still in its infancy, with obvious challenges around targeting damaged cells and creating corrective genes. An equally important challenge, addressed by this research, is finding ways to transport the corrective genes into the cell. This is a problem, because of the poor permeability of cell membranes.

This research describes a model peptide sequence, dubbed GeT (gene transporter), which wraps around genes, transports them through cell membranes and helps their escape from intracellular degradation traps. The process mimics the mechanisms viruses use to infect human cells.

GeT was designed to undergo differential membrane-induced folding - a process whereby the peptide changes its structure in response to only one type of membranes. This enables the peptide, and viruses, to carry genes into the cell. Interestingly, the property also makes it antibacterial and so capable of gene transfer even in bacteria-challenged environments.

To prove the concept, the researchers used GeT to transfer a synthetic gene encoding for a green fluorescent protein a protein whose fluorescence in cells can be seen and monitored using fluorescence microscopy.

The design can serve as a potential template for non-viral delivery systems and specialist treatments of genetic disorders.

This research, performed at NPL, is a part of the NPL-led international research project 'Multiscale measurements in biophysical systems', which is jointly funded by NPL and the Scottish Universities Physics Alliance.


'/>"/>

Contact: David Lewis
david@proofcommunication.com
44-845-680-1865
National Physical Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/16/2015)... Between 16 and 20 ... innovations in biometric identification at the CeBIT exhibition ...      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ) , ... at the forefront: the company,s all new BiometricGate ... Germany . BiometricGate is the first ...
(Date:3/12/2015)... 12, 2015 The mascots of the Atlantic ... part of Wake Forest Baptist Medical Center. They stopped ... 2015 ACC Men,s Basketball Tournament. Young patients enjoyed bonding ... getting their autographs. Brenner Children,s Hospital is ... the only children,s hospital in northwest North ...
(Date:3/12/2015)... , March 12, 2015 WHEN:Tuesday, March 17, ... here: http://bit.ly/1G7Os0L . SPEAKERS: , Frost & ... - http://photos.prnewswire.com/prnh/20150311/181111 Biometric companies ... compete in several different markets and industries. This ... witnessing an uptrend. Join Frost ...
Breaking Biology News(10 mins):DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 2Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 3
... critical point of failure in the microscopic transport system that ... study, published today in Nature Communications , explains how ... drugs and, as such, how this new discovery reveals how ... called ,railway, are tiny tubes, called microtubules, 1000 times thinner ...
... powerful gene-editing tool may be able to improve its ... in Nature Biotechnology , Massachusetts General Hospital (MGH) ... guide RNA (gRNA) component of the synthetic enzymes called ... of DNA mutations at sites other than the intended ...
... University of Hawaii Manoa (UHM) School of Ocean ... Laboratory, Lawrence Berkeley National Laboratory, and University of California ... deliver water and organics to the Earth and other ... come from comets, asteroids, and leftover debris from the ...
Cached Biology News:Cracks in the cellular transport system can be key to a new generation of cancer therapies 2Shortening guide RNA markedly improves specificity of CRISPR-Cas nucleases 2University of Hawaii scientists make a big splash 2University of Hawaii scientists make a big splash 3
(Date:4/1/2015)... , April 1, 2015  Spherix Incorporated ... committed to the fostering and monetization of intellectual ... a privately held full service global investment bank ... issued an industry note featuring Spherix. ... CFA, a Senior Analyst at Chardan, was published ...
(Date:4/1/2015)... April 01, 2015 National recruitment firm ... placement of Brad Allen as Head of Sales at ... health system market. , Allen brings over 20 ... sales at a number of companies including Dell Services ... and experience were a perfect fit for accomplishing the ...
(Date:3/31/2015)... and VANCOUVER , March 31, 2015 ... EPI) announced today that it has filed with the ... Investigation New Drug ("IND") application related to the Company,s ... Approval of the IND application is required in order ... the US.  The IND application is ...
(Date:3/31/2015)... -- Sonoa Health, a health tech startup based in ... consumer health portal, Health&, which brings together data from ... Today, the Company appointed respected investment banker ... to the table more than 18-years experience in investment ... with the biggest names in Silicon Valley in the ...
Breaking Biology Technology:Chardan Capital Issues Industry Note Covering Spherix 2Chardan Capital Issues Industry Note Covering Spherix 3Slone Partners Fills Head of Sales at Optimal Medicine 2ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 2ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 3ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 4Investment Banker Appointed CEO of Australian Health Tech Start-Up 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 3
... 6 Iomai Corporation,(Nasdaq: IOMI ) today announced ... officer, will present at the 10th Annual BIO,CEO & ... 12. Mr. Erck,s,presentation will begin at 2 p.m. Eastern ... Mr. Erck will give an update on corporate ...
... LARGO, Fla., Feb. 6 GeoPharma, Inc. (Nasdaq:,GORX) (the ... story,to as wide of an audience as possible it ... the company on its website at, http://www.GeoPharmainc.com under ... that it will be speaking publicly several times in,the ...
... Choices ( http://www.nhs.uk ), the,online ,front door, to ... measure your body mass index (BMI)., Based ... ) enables users to calculate in,seconds what their ... on maintaining or obtaining a healthy BMI. This ...
Cached Biology Technology:Iomai CEO to Speak at BIO CEO & Investor Forum on Feb. 12 2Recent Research Reports and Near-Term Corporate Events 2Recent Research Reports and Near-Term Corporate Events 3
RECOMBINANT EQUINE IL-4 Product Type: Recombinant Protein...
Request Info...
...
... concentrated solutions. REact Buffer SetConsists of one 1 ... and one 250 microl vial of 10 mM ... of REact 1 Buffer four 1 ml vials ... of REact 3 Buffer and four 1 ml ...
Biology Products: