Navigation Links
Scientists capture 'redox moments' in living cells
Date:11/24/2013

roteins operate by adding or subtracting electrons.

His team uncovered an extensive network of redox activity, identifying 176 proteins that are sensitive to signaling in this manner. Before this study, just 75 of those proteins were known to be part of a redox signaling network. The scientists found that the system is involved in all the major processes of a cell which genes are turned on and off, for example, as well as how the cell maintains its molecular machinery and converts energy into fuel.

Central to the work are the chemical probes Wright developed that are able to cross the cell membrane and get into the cytoplasm of the cell. The probes flag redox events by binding to certain forms of the amino acid cysteine, which is a known player in many of these interactions. Then the probes and the interactions they flag are subjected to scrutiny at EMSL, the DOE's Environmental Molecular Sciences Laboratory on the PNNL campus, where instruments detect redox activity through various means, such as through fluorescent imaging and mass spectrometry. The analysis tells scientists about when and where within the cell redox activity occurred.

"Knowing the proteins that are sensitive to redox signaling lets us know where to look as we test out new methods for working with this organism," said Wright. "We can tinker with a specific protein, for instance, and then watch the effects immediately.

"This is the type of information we really must have if we want organisms like this to produce substances that make a difference, like biofuels, chemicals or potential medicines," he added.


'/>"/>

Contact: Tom Rickey
tom.rickey@pnnl.gov
509-375-3772
DOE/Pacific Northwest National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists prove X-ray laser can solve protein structures from scratch
2. Scientists find brain region that helps you make up your mind
3. In plant photosynthesis, scientists see clues for improving solar energy cells
4. Scientists have been able to grow artificial skin using stem cells from the umbilical cord
5. Spanish scientists identify a new ancestral enzyme that facilitates DNA repair
6. UT Dallas computer scientists create 3-D technique
7. Salk scientists for the first time generate mini-kidney structures from human stem cells
8. The Gorgons of the eastern Pacific: scientists describe 2 new gorgonian soft coral species
9. Bleeding symptom leads scientists to intracellular traffickers role in virus propagation
10. Patients and scientists join forces to tackle Friedreichs Ataxia
11. Protein-rich breakfast helps to curb appetite throughout the morning, scientists find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists capture 'redox moments' in living cells
(Date:8/28/2014)... ROCHESTER, Minn. A Mayo Clinic researcher and his ... speed up and enhance the process of re-engineering cells ... that uses network biology methods to aid stem cell ... cell engineering are described in two back-to-back papers in ... has a broad range of uses for all types ...
(Date:8/28/2014)... peer groups and clinicians is critical to the ... University of Georgia research. , A qualitative study ... determined that role models for successful breastfeeding help ... , "Mothers who received that support are more ... co-author Alex Anderson, an associate professor in the ...
(Date:8/28/2014)... A unique method for delivering compounds that ... HIV and AIDS may be possible, thanks ... Agricultural Sciences., A semi-soft vaginal suppository made ... loaded with the antiviral drug Tenofovir provides ... against the spread of sexually transmitted infections ...
Breaking Biology News(10 mins):New tool aids stem cell engineering for medical research 2Breastfeeding study shows need for effective peer counseling programs 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3
... analysis of a skull from the most complete early ... complex human brain may have evolved more rapidly than ... other human characteristics. While some features of ... precision-grip hand, the brain was more ape-like, says Emory ...
... faster than ever and not only when it ... bodies are reaching puberty at an increasingly earlier age, ... adult lives. That,s bad news, according to Tel Aviv ... Hyperostosis Frontalis Interna (HFI), a hormonal condition once typically ...
... it comes to human evolution. That seems to ... humans, somewhere in Africa during the last 20-60 thousand ... amounts of genetic material to their offspring who are ... and a team of evolutionary biologists, geneticists and mathematicians ...
Cached Biology News:Sediba hominid skull hints at later brain evolution 2Sediba hominid skull hints at later brain evolution 3Is estrogen going to your head? 2Is estrogen going to your head? 3Evolution's past is modern human's present 2Evolution's past is modern human's present 3
(Date:8/29/2014)... DIEGO, Aug. 29, 2014  Pfenex Inc. (NYSE ... the development of high-value and difficult to manufacture ... update and reported financial results for the second ... the successful completion of our initial public offering, ... our biosimilar product candidates, derived from our proprietary ...
(Date:8/29/2014)... August 29, 2014 The global ... billion in 2019. It is expected to grow ... 2019, and was valued at $1.8 billion in ... Transparency Market Research. , For more information regarding ... . , The research report, titled “Companion Diagnostics ...
(Date:8/29/2014)... August 29, 2014 Pittcon is pleased ... and colleague Koichiro Matsuda, Horiba Scientific, have organized a ... 5, 2014. JASIS , Asia’s largest analytical and ... in Makuhari Messe, Japan. , The four speakers ... Bioanalysis from Single Molecules to Single Cells” will present ...
(Date:8/29/2014)... 29, 2014 Local veterinarian, Dr. Keith ... are seeking candidates to participate in an investigational study ... The ultimate goal of this study is to determine ... one or two arthritically affected joints can help reduce ... Candidates for the current investigational study must be older ...
Breaking Biology Technology:Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... researchers have created a nanoscale light sensor that can ... optic and electronic devices with new functionality. The team, ... at Madison, reports in Nature Photonics that ... The group, led by Jeremy Levy, a professor ...
... the 2010 ICO Prize for pioneering contributions to attosecond ... scientific discipline is to capture snapshots of the inner ... important insights into the actual course of chemical reactions, ... interactions between light and matter. "An attosecond is ...
... ... ... var shortURL = ""; BitlyCB.alertResponse = function(data) ... first one. for (var r in data.results) { first_result = data.results[r]; break; } for (var key in first_result) { ...
Cached Biology Technology:Pitt-led team develops nanoscale light sensor compatible with 'Etch-a-Sketch' nanoelectronic platform 22010 ICO Prize is awarded to TUM physicist Reinhard Kienberger 2MEDICAGO ANNOUNCES 2010 THIRD QUARTER FINANCIAL RESULTS 2MEDICAGO ANNOUNCES 2010 THIRD QUARTER FINANCIAL RESULTS 3MEDICAGO ANNOUNCES 2010 THIRD QUARTER FINANCIAL RESULTS 4MEDICAGO ANNOUNCES 2010 THIRD QUARTER FINANCIAL RESULTS 5MEDICAGO ANNOUNCES 2010 THIRD QUARTER FINANCIAL RESULTS 6MEDICAGO ANNOUNCES 2010 THIRD QUARTER FINANCIAL RESULTS 7MEDICAGO ANNOUNCES 2010 THIRD QUARTER FINANCIAL RESULTS 8MEDICAGO ANNOUNCES 2010 THIRD QUARTER FINANCIAL RESULTS 9