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Scientists can predict nano drug outcome
Date:2/5/2009

tumors that have pores up to eight times the size of these miniaturized drug carriers. If a liposome with contrast agents can penetrate a tumor and be detected by X-rays, there is a good chance that a liposome with anti-cancer agents can enter the tumor, too. "We found that different tumors light up differently. The tumors that light up well take up the agent. Consequently, these are the tumors most likely to respond to liposomal doxorubicin," Annapragada said.

The current clinical protocols for liposomal doxorubicin consist of a standard dose every three to four weeks, the authors wrote. No prior knowledge of tumor vessel status, especially leakiness, is taken into account for the dose scheduling. However, it is well known that the degree of tumor vasculature leakiness differs not only among same-type tumors, but even spatially in the same tumor.

"This new information could help personalize the treatment of cancer with liposomal doxorubicin," Annapragada said.

In addition to predicting the outcome of liposomal doxorubicin on breast tumors, liposomes can be used for live monitoring of anti-cancer agents in action. When loaded with both contrast agents and liposomal doxorubicin, the liposomes provide information on tumor leakiness, which can be used in tumor prognostication. A pre-clinical study on multi-functional liposomes by many of the same researchers was published in Biomaterials in December.

Annapragada and the study's other senior author, Ravi V. Bellamkonda, Ph.D., of the Georgia Institute of Technology/Emory University, are involved in a UT Health Science Center at Houston portfolio start-up company called Marval Biosciences that is working to translate these enhanced medical imaging techniques into patient diagnostics.


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Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3042
University of Texas Health Science Center at Houston
Source:Eurekalert

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