Navigation Links
Scientists can predict nano drug outcome
Date:2/5/2009

Scientists including one from The University of Texas Health Science Center at Houston successfully predicted the outcome of a nano drug on breast tumors in a pre-clinical study. Their research could help determine which patients will respond best to cancer-fighting nano drugs.

Researchers from the Georgia Institute of Technology and Emory University also participated in the study, which appears in the February issue of Radiology.

The investigators used contrast agents encapsulated in tiny fat bubbles called liposomes to determine if breast tumors in rodents could be breached by liposomes loaded with a cancer drug called liposomal doxorubicin. The liposomes were administered intravenously.

When scientists X-rayed the rodents, the investigators received good images of porous breast tumors which had absorbed the contrast agents. On the other hand, poor images indicated the contrast agents had not substantially penetrated the tumor. When liposomal doxorubicin was administered, it was associated with better therapeutic results in the tumors with superior images.

"We can tell if the animals are candidates for the treatment or not," said Ananth Annapragada Ph.D., one of two senior authors and an associate professor at The University of Texas School of Health Information Sciences at Houston.

Higher uptake of the probe by the tumor, indicating leakier vasculature, was associated with a slower tumor growth rate, suggesting a better therapeutic outcome with liposomal doxorubicin, the authors wrote. A nanometer is a billionth of a meter and a liposome is about 100 nanometers.

Nano drugs for cancer like liposomal doxorubicin are designed to increase the amount of drug reaching tumors. Currently, when an intravenous cancer drug is administered, very little reaches its intended target. The remaining drug circulates in the bloodstream and can cause side effects.

Liposomes carrying drugs infiltrate leaky
'/>"/>

Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3042
University of Texas Health Science Center at Houston
Source:Eurekalert

Page: 1 2

Related biology news :

1. CSHL scientists discover how companion cells to sperm protect them from genetic damage
2. Weizmann Institute scientists show extra copies of a gene carry extra risk
3. Scientists discover how deadly fungus protects itself
4. Scientists discover hot spot for toxic HABS off Washington coastline
5. Scientists uncover new class of non-protein coding genes in mammals with key functions
6. Smithsonian scientists receive coveted BBVA Ecology and Conservation Award
7. CSHL scientists clarify editing error underlying genetic neurodegenerative disease
8. Weizmann Institute scientists discover how cancer cells survive a chemotherapy drug
9. Substantial work ahead for water issues, say scientists at ACS Final Report briefing
10. CSHL scientists find a new class of small RNAs and define its function
11. Scientists uncover new genetic variations linked to psoriasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 11, 2014 Research and Markets ... Technology Market - Industry Analysis Size Share Growth Trends ... http://photos.prnewswire.com/prnh/20130307/600769 ... created a need for high level security in both ... authentication such as username and passwords, tokens etc. are ...
(Date:7/10/2014)... other major cities in New Mexico, nearly every public ... rather than precious potable water supplies. Across the U.S. ... golf courses receive treated effluent. Reusing the effluent increases ... courses and homeowners alike fertilize their lawns during the ... A New Mexico State University turfgrass expert has a ...
(Date:7/10/2014)...  Aware, Inc. (NASDAQ: AWRE ), a ... on June 26, 2014 that its Board of Directors ... share, or approximately $40 million in total.  The Board ... a payment date of July 24, 2014.  The Company ... an ex-dividend date for this special cash dividend.  An ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2'Tailored' water -- the latest in lawn care 2NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2
... Clinic,s Genomic Medicine Institute have revealed multiple genetic discoveries that ... patients who are predisposed to breast and kidney cancer. ... cancerous tumors, is published in the Dec. 22 issue of ... JAMA ). Charis Eng, M.D., Ph.D, Chair of ...
... The leading causes of death have shifted from infectious diseases ... illnesses may be affected by diet. In a study published ... the American Dietetic Association , researchers investigated empirical data regarding ... the eating patterns of over 2500 adults between the ages ...
... , ARLINGTON, Va. Dubbed the "Brilliant 10" by ... 2010 list of top young scientists have received funding ... two ONR-funded researchers are Dr. Chiara Daraio, a 2010 ... and designed a nonlinear acoustic lens, which has the ...
Cached Biology News:Researchers discover genetic predisposition for breast, kidney cancers 2Eating healthier means living longer 2ONR-funded researchers among Popular Science magazine's 'Brilliant 10' 2
(Date:7/10/2014)... 10, 2014 Product and process ... low abundance and are often “lost in the ... , Join presenters Dr. Rowel Tobias, Senior Scientist, ... Anders, Head of Quality at Nanotherapeutics, Inc., to ... can speed detection and quantitation while achieving the ...
(Date:7/10/2014)... 10, 2014 Unraveling life’s mysteries can ... The Archer Family purchased a DNA test ... ended up with a lifetime of memories, sharing, and ... family members’ DNA genuinely brought the family closer together. ... deeper into genetic history and prior to taking the ...
(Date:7/10/2014)... Senior supply chain management executives from over 50 ... of “Reducing Cost, Lead Time, & Defects in the ... the partnership of the Bio Supply Management Alliance ( ... SCMI) of the University of San Diego in ... Institute of Peace and Justice in San Diego, Devendra ...
(Date:7/10/2014)... , July 10, 2014 /PRNewswire-iReach/ -- Tute ... interpretation, today announced an agreement with Lineagen, ... for Lineagen,s NextStep Dx PLUS.  Lineagen, ... and neurological disorders, currently offers FirstStep Dx ... testing service used by healthcare providers as ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... 30 , - 76% Higher ... Control Versus Lantus(R) , Sanofi-aventis (EURONEXT: ... a,head-to-head study providing further evidence on the efficacy of once-daily,24-hour ... detemir. The study was presented during the 45th,Annual Meeting of ...
... Dr. John McPherson, Platform Leader, Cancer Genomics and High-Throughput ... Ontario Institute for Cancer Research (OICR) led a team ... the NEBNext(TM) DNA Sample Prep Reagents for use with ... the evaluation, "We are constantly striving for the best ...
... physicists have created the first atomic-scale maps of ... of producing "designer dots" that can be tailored ... atoms or nanoparticles---are tiny semiconductor crystals with wide-ranging ... and other technologies. Each dot is a well-ordered ...
Cached Biology Technology:Superior Efficacy-dose Ratio for Lantus(R) Over detemir 2Superior Efficacy-dose Ratio for Lantus(R) Over detemir 3Superior Efficacy-dose Ratio for Lantus(R) Over detemir 4Superior Efficacy-dose Ratio for Lantus(R) Over detemir 5Ontario Institute for Cancer Research Validates NEBNext(TM) DNA Sample Preparation Reagents from New England Biolabs for use in Next Generation Sequencing 2U-M physicists create first atomic-scale map of quantum dots 2