Navigation Links
Scientists can now screen for stem cells that enhance corneal regrowth
Date:7/2/2014

A Boston-based scientific collaborative, led by Harvard Stem Cell Institute (HSCI) researchers, has discovered a way to collect the best cell type for regenerating a damaged corneathe clear membrane that covers the pupil and directs light into the back of the eye. The investigators report in the journal Nature that purified human stem cells can be used to improve long-term vision in mice. The team is now pursuing FDA-approval for the technique before moving on to patient clinical trials.

The study, lead by co-senior investigators Natasha Frank, MD, and Markus Frank, MD, was a highly collaborative effort, with work done at Massachusetts Eye and Ear/Schepens Eye Research Institute, Boston Children's Hospital, Brigham and Women's Hospital, and the US Department of Veterans Affairs Boston Healthcare System.

Corneal blindness is a clouding of vision that results when blood vessels grow into the cornea. It can be caused by an injury, infection, or autoimmune disease that destroys an actively regenerating population of stem cells located in an area behind the cornea, called the limbus. Limbal stem cell transplants from an uninjured eye or deceased organ donor have had promising results, but outcomes have been inconsistent.

"Previously published work on limbal epithelial cell grafts showed that when more than three percent of transplanted cells were stem cells, transplants were successfulless than three percent and the transplants were not, "said HSCI Affiliated Faculty member Natasha Frank.

"The question in the field then was whether we could enrich the limbal stem cells. But until this study there was no specific marker that could isolate these cells," added Frank, who is a physician of the VA Boston Healthcare System and Brigham and Women's Hospital, and a Harvard Medical School assistant professor of medicine in the Division of Genetics at Brigham and Women's Hospital.

The biological marker the researchers
'/>"/>

Contact: B.D. Colen
bd_colen@harvard.edu
617-413-1224
Harvard University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Clemson scientists: Kudzu can release soil carbon, accelerate global warming
2. Scientists uncover the key to adaptation limits of ocean dwellers
3. Scientists chart a baby boom -- in southwestern Native-Americans from 500 to 1300 A.D.
4. Oil palm plantations threaten water quality, Stanford scientists say
5. A first: Scientists show bacteria can evolve a biological timer to survive antibiotics
6. Scientists study effects of warming on tropical rainforests
7. Scientists identify new pathogenic and protective microbes associated with severe diarrhea
8. Scientists identify new pathogenic & protective microbes associated with severe diarrhea
9. New species of small mammal discovered by scientists from California Academy of Sciences
10. Fruit flies help scientists uncover genes responsible for human communication
11. Net energy analysis should become a standard policy tool, Stanford scientists say
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists can now screen for stem cells that enhance corneal regrowth
(Date:7/31/2014)... NXT-ID, Inc., (NXTD: OTCQB) a biometric authentication company ... and consumers wanting to learn more about its  ... on-air today, July 31 st . ... featured in a segment of NewsWatch, a weekly ... the History Channel, FYI Network today. ...
(Date:7/30/2014)... by the Red Queen in Lewis Carroll,s Through ... Illinois and National University of Singapore improved a ... evolve over decades to millions of years. , ... for competition, incorporates the "Red Queen Effect," an ... the 1970s, which suggests that organisms must constantly ...
(Date:7/30/2014)... the Entomological Society of America (ESA) has elected ten ... as a Fellow acknowledges outstanding contributions to entomology in ... or administration. The following Fellows will be recognized during ... will be held November 16-19, 2014 in Portland, Oregon. ... professor with the Department of Plant, Soil and Entomological ...
Breaking Biology News(10 mins):NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 2NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 3Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3Entomological Society of America recognizes 2014 fellows 2Entomological Society of America recognizes 2014 fellows 3Entomological Society of America recognizes 2014 fellows 4Entomological Society of America recognizes 2014 fellows 5Entomological Society of America recognizes 2014 fellows 6Entomological Society of America recognizes 2014 fellows 7Entomological Society of America recognizes 2014 fellows 8Entomological Society of America recognizes 2014 fellows 9Entomological Society of America recognizes 2014 fellows 10Entomological Society of America recognizes 2014 fellows 11Entomological Society of America recognizes 2014 fellows 12Entomological Society of America recognizes 2014 fellows 13Entomological Society of America recognizes 2014 fellows 14Entomological Society of America recognizes 2014 fellows 15Entomological Society of America recognizes 2014 fellows 16Entomological Society of America recognizes 2014 fellows 17
... the predator-prey relationship can affect the flow of carbon ... environment may offer a new way of looking at ... The study, conducted by researchers at the Yale ... week in the Proceedings of the National Academy ...
... due to rising carbon dioxide levels will reduce the density ... and erosion, according to a new study of corals growing ... The study, led by researchers at the University of ... the National Academy of Sciences ( PNAS ), is ...
... A University of Maryland-led team of policy experts ... of climate change could affect civil conflicts. The team ... socio-economic conditions and climate. They will use these to ... U.S. Department of Defense is funding the research through ...
Cached Biology News:New study shows predators affect the carbon cycle 2Submarine springs reveal how coral reefs respond to ocean acidification 2DoD-funded research: Can climate change heat up conflict? 2
(Date:7/31/2014)... 2014 Although RNA-Sequencing is a ... transcriptome-wide analyses appearing around 2008, RNA-Sequencing has rapidly ... measurement. In the last several years, assays have ... with smaller input amounts, process degraded RNA, and ... On the bioinformatics side, there have been improvements ...
(Date:7/31/2014)... 2014 SoundConnect , an ... is proud to announce the addition of Adobe ... Connect’s elearning tools to quickly deploy and manage ... training tools for desktop and mobile learning solutions. ... the perfect online training solution, enabling organizations to ...
(Date:7/31/2014)... July 31, 2014 Sales Horizons, a ... its online sales training course – Mastering the ... sales performance. , Drawn from proven sales training programs ... Mastering the Complex Sale online sales training course is ... who has face-to-face contact with customers, like technical support, ...
(Date:7/30/2014)... 2014 W. R. Grace & ... the REVELERIS® Prep purification system , a ... and other researchers to perform both flash and ... , With the REVELERIS® Prep purification system, researchers ... modes with a simple touch of the screen, ...
Breaking Biology Technology:The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 3Grace Launches New REVELERIS® Prep Purification System 2
... AURORA, Ontario, June 19 Helix BioPharma Corp. (TSX, ... scientific officer at Helix BioPharma Corp., will be presenting ... at the 2009 American Association of Pharmaceutical Scientists ("AAPS") ... 24th at the Washington State Convention and Trade Center ...
... BEIJING, June 19 /PRNewswire-Asia/ -- Sinovac Biotech Ltd.,(NYSE ... of vaccines in China,announced today that the Company received the ... to the Beijing government. The initial order,consists of 4 million ... of,September. This order will be administered to 2 million ...
... and efficacy of Albuferon administered every four weeks in combination ... C - , , ROCKVILLE, Md., June 19 ... announced that Novartis has completed enrollment and initial dosing in ... efficacy of Albuferon(R) (albinterferon alfa-2b) administered monthly in combination with ...
Cached Biology Technology:Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 2Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 3Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 4Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 5Sinovac Receives China's First Influenza A (H1N1) Vaccine Order 2Sinovac Receives China's First Influenza A (H1N1) Vaccine Order 3Human Genome Sciences Announces Completion of Enrollment in Phase 2b Monthly-Dosing Trial of Albuferon(R) 2Human Genome Sciences Announces Completion of Enrollment in Phase 2b Monthly-Dosing Trial of Albuferon(R) 3Human Genome Sciences Announces Completion of Enrollment in Phase 2b Monthly-Dosing Trial of Albuferon(R) 4
... a wide variety of purity levels, scales and ... Purity: IG(>50%), >70%, >80% and >95% ... Length: Up to 120 residues ... acids, MAPs, KLH/BSA conjugation, and much more. ...
... H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH 2 (Disulfide ... peptide and 1 ... I-labelled peptide, please see ... ([ 1 2 ...
... ProteinPilot Software enables you to identify ... you can distinguish protein isoforms, protein ... can also visualize peptide-protein associations and ... for protein identification and relative protein ...
... offer all of the features of a ... with Koehler illumination, a centerable condenser and ... is the workhorse of Motic's range of ... need for re-focusing following a change in ...
Biology Products: