Hua's lab has found that menin appears to suppress a pro-proliferative signaling pathway via protein methylation. As menin mutations are linked to pancreatic neuroendocrine tumors, his findings raise the possibility that targeting the menin-regulated signaling pathway may be crucial for treating neuroendocrine tumors. This project is intended to unravel the crucial role of the menin-regulated cascade in the maintenance of neuroendocrine tumors, underscoring the pathway as an important target for therapy against neuroendocrine tumors.
Rudin's research group focuses on novel cancer therapeutic development. One of the therapeutic approaches they have been most interested in is the use of a small RNA virus that can selectively infect and destroy certain cancers, especially cancers with neuroendocrine features. Their funded project, Oncolytic Viral Therapy for Carcinoid and Other Neuroendocrine Tumors, will seek to better define how this virus selectively targets cancer cells, in order to guide subsequent clinical application in patients with aggressive neuroendocrine cancers such as atypical carcinoid and small cell carcinoma.
2011 Raymond and Beverly Sackler AACR Fellowships for Ileal Carcinoid Tumor Research: These two-year grants of $100,000 ($50,000 per year) support basic, translational, clinical or epidemiological research with direct application and relevance to ileal carcinoid tumors.
Li's project, cAMP regulation of carcinoid proliferation and function, focuses on the possibility that the hormo
|Contact: Michele Sharp|
American Association for Cancer Research