Navigation Links
Scientists at the UA make critical end-stage liver disease discovery
Date:4/25/2014

A team of researchers in the University of Arizona's College of Pharmacy has discovered a molecular pathway that could be key to creating new therapeutics that would slow or even reverse the progression of end-stage liver disease.

Although cirrhosis of the liver is most commonly associated with alcohol or drug abuse, the condition marked by scar tissue replacing healthy liver tissue also can result from viral hepatitis, obesity and diabetes, as well as certain inherited diseases. According to the National Institutes of Health, cirrhosis is the 12th leading cause of death by disease in the U.S. As with many other human pathologic conditions, end-stage liver disease goes hand in hand with oxidative stress, which refers to damage inflicted to biological tissues by reactive oxygen molecules. Such molecules, also called free radicals, occur naturally as a byproduct of metabolic processes in the body and are associated with many chronic diseases including cancer, diabetes, neurodegenerative and cardiovascular diseases.

"Cells keep oxidative stress under control through various mechanisms," said Donna Zhang, a professor in the UA Department of Pharmacology and Toxicology, explaining that most of these mechanisms involve Nrf2, a protein present in virtually every cell that acts as a molecular switch. Nrf2 activates various biochemical mechanisms inside the cell that capture reactive oxygen molecules or dispose of damaged cellular components before they can cause more trouble. The antioxidants found in many fruits and vegetables exert their healthful benefits by capturing reactive oxygen molecules.

Under normal, healthy conditions, when no oxidative stress response is needed, an enzyme called Keap1 constantly chews up Nrf2, keeping its level low.

"Then, under stress from reactive oxygen molecules, or when you eat antioxidants from certain plants like broccoli sprouts, it prevents Keap1 from eating up Nrf2, allowing it to accumu
'/>"/>

Contact: Daniel Stolte
stolte@email.arizona.edu
520-626-4402
University of Arizona
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scripps Florida scientists find connection between gene mutation, key symptoms of autism
2. Microscopic organism plays a big role in ocean carbon cycling, Scripps scientists discover
3. Cell resiliency surprises scientists
4. Scientists identify source of mysterious sound in the Southern Ocean
5. Scientists identify critical new protein complex involved in learning and memory
6. Scientists target receptor to treat diabetic retinopathy
7. Five scientists awarded prestigious Heineken Prizes
8. Neuroscientists: Brain activity may mark the beginning of memories
9. Scientists reconstruct ancient impact that dwarfs dinosaur-extinction blast
10. Scientists reveal potential link between brain development and breast cancer gene
11. Scientists disagree on responsible research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists at the UA make critical end-stage liver disease discovery
(Date:4/27/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces that its ... the first week of May, 2015 and will be ... Gino Pereira , Chief Executive ... company as Wocket® enters the consumer market. We would ...
(Date:4/20/2015)... 20, 2015 Huntington Memorial Hospital is the ... a new miniaturized, wireless monitoring sensor to manage heart ... and only FDA-approved heart failure monitoring device that has ... by physicians to manage heart failure. The ... in the pulmonary artery (PA) during a non-surgical procedure ...
(Date:4/14/2015)... NEW YORK , April 14, 2015 /PRNewswire/ ... Fast IDentity Online (FIDO ® ) Alliance tm ... standards-based specifications. FIDO members commit to share technology ... authentication methods that are interoperable, more secure and ... specifications enable biometric identity verification that protects sensitive ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3
... melodies accurately, according to a new study by the ... Kaiserslautern in Germany. Their analysis of human melody singing ... The work is published online in Springer,s journal ... be one of the most complex and demanding cognitive ...
... Down syndrome, more commonly known as "trisomy 21" is ... population: Alzheimer,s disease, leukemia, or cardiac deficiency. In a ... Faculty of Medicine of the University of Geneva (UNIGE), ... 21, determining the risk of congenital heart disease in ...
... in the southern Australian-New Zealand region has been identified ... Nature journal Scientific Reports , demonstrates that ... into the Southern Ocean by rising global temperatures associated ... of strong El Nios in recent decades, which should ...
Cached Biology News:Songbirds turn on and tune up 2Complex genetic architectures: Some common symptoms of trisomy 21 2Climate tug of war disrupting Australian atmospheric circulation patterns 2
(Date:4/30/2015)... April 30, 2015  Pfenex Inc. (NYSE MKT: ... development of biosimilar therapeutics including high value and ... of its previously announced underwritten public offering of ... public offering price of $15.50 per share. This ... of their option to purchase up to 750,000 ...
(Date:4/30/2015)... 2015 Available in select spas ... , Phytomer’s DOUCEUR INTEMPORELLE Restorative Shield Cream ... while battling the weakening threat of inflammaging, aging ... formulated with star ingredient GLYCOSEA, a complex of ... complex of soothing minerals and trace elements. GLYCOSEA ...
(Date:4/29/2015)... Washington, and BALTIMORE, Maryland, USA (PRWEB) April 29, 2015 ... event for photonics, optical sensing, and imaging on the ... place for government program managers, researchers, applications developers, and ... technology of sensing and imaging for multiple applications. , ... defense and security, and commercial and scientific sensing and ...
(Date:4/29/2015)... 2015 The leading Regenerative Veterinary Medicine ... regenerative stem cell therapy has processed more than 11,000 ... discover a successful treatment for horses with potentially fatal ... signed a worldwide exclusive license for adipose-derived (fat derived) ... horse was treated in January 2004. Shortly after, the ...
Breaking Biology Technology:Pfenex Inc. Announces Closing of Public Offering of Common Stock and Full Exercise of Underwriters' Option to Purchase Additional Shares 2Phytomer introduces DOUCEUR INTEMPORELLE Restorative Shield Cream 2Phytomer introduces DOUCEUR INTEMPORELLE Restorative Shield Cream 3SPIE DSS provides venue for collaboration vital to research, applications advances 2SPIE DSS provides venue for collaboration vital to research, applications advances 3SPIE DSS provides venue for collaboration vital to research, applications advances 4VetStem Biopharma -Regenerative Cell Therapy has processed over 11,000 samples 2
... , , ... May 11 /PRNewswire-FirstCall/ - Quest PharmaTech Inc. (TSX-V: QPT) ... for the treatment of cancer, today announced the dosing of the ... with SL052 Photodynamic Therapy in prostate cancer patients. The study will ...
... HARBIN, China , May 11 /PRNewswire-Asia-FirstCall/ -- ... Company") (Nasdaq: CSKI ), a leading,fully integrated pharmaceutical company ... ("PRC"), today announced the Company attended,the 107th China Import and ... May 1st,to 5th, 2010 and generated significant interest from ...
... N30 Pharma (N30), a biopharmaceutical company focused on the discovery and development of ... that it has completed a $10 million financing and expanded its Board ... Joining the Company,s Board of Directors ... , , ...
Cached Biology Technology:Quest PharmaTech Announces Dosing Of First Patient In Its Prostate Cancer Clinical Trial 2Quest PharmaTech Announces Dosing Of First Patient In Its Prostate Cancer Clinical Trial 3China Sky One Medical Attended Import and Export Fair to Enhance International Growth Opportunity 2China Sky One Medical Attended Import and Export Fair to Enhance International Growth Opportunity 3China Sky One Medical Attended Import and Export Fair to Enhance International Growth Opportunity 4
Ezrin/Radixin/Moesin Antibody...
Ezrin/Radixin/Moesin Antibody...
ABCA1 Immunogen: Mouse ABCA1-expressing HeLa stable transfectants. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Goat polyclonal to SART3 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSNADFAKLFLRK, corresponding to C terminal amino acids 951-963 of Human SART3 Entrez Gene ID: 9...
Biology Products: