Navigation Links
Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants
Date:3/18/2009

"Establishment of a gradient of mobile small RNAs can create profound differences between neighboring cells by altering their gene activity patterns," Timmermans says. "This is a neat way of dividing a cluster of cells into distinct sections with sharply drawn boundaries."

The top-to-bottom, abundant-to-rare distribution, or "concentration gradient," of ta-siRNAs ensures that the activity of ARF3 is strongly inhibited in the leaf's top half, but mildly or hardly affected at the bottom, thus creating a sharp boundary between leaf sections with different fates.

Ta-siRNA biogenesis is spatially controlled

In addition to mobility, the team attributes the unique distribution pattern of these small RNAs to the way they are produced within the leaf a biochemical process involving several complicated steps.

The small ta-siRNAs are generated from larger RNA strands called precursors that are snipped at specific sites. Two cellular ingredients ensure that the cuts occur in the right place: a microRNA molecule called miR390 that specifies the location of the first cut, and an enzyme called ARGONAUTE7 (AGO7) that ferries miR390 to this location and creates the cut.

The CSHL team found that although miR390 is present in all cells of the leaf, the precursors and ARGONAUTE7 are strictly restricted to only the cells in the two uppermost layers. The ta-siRNAs are therefore generated exclusively in these upper cell layers, from where they move to the lower side of the leaf, accumulating as a gradient.

Thus, besides identifying the first example of a morphogen-like small RNA signal, Timmermans and her team have also shown that the location of the various biochemical ingredients required for small RNA activity can impact pattern formation. Together, their discoveries explain how mobile small RNAs can generate patterns during development.


'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps research scientists watch as individual alpha-synuclein proteins change shape
2. Gladstone scientists reveal key enzyme in fat absorption
3. Geoscientists discuss sea level rise, extreme storm events and more
4. Scientists gather to protect global food security from return of devastating wheat fungus
5. Antibody key to treating variant CJD, scientists find
6. Undesirable evolution can be reversed in fish, Stony Brook University scientists show
7. Lincoln Park Zoo scientists awarded National Institutes of Health grant
8. JCVI program trains USDA scientists on eukaryotic genome analysis
9. Monash scientists debug superbug
10. Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants
11. Scientists unlock the secrets of C. difficiles protective shell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... , July 30, 2014 NexID ... and liveness detection solutions for the biometric authentication ... industry consortium revolutionizing online authentication with standards for ... Cornett , "The decision to join FIDO Alliance ... authentication pervasive in use. We believe the FIDO ...
(Date:7/30/2014)... across-the-board increase in Impact Factors for its molecular ... Reports (Thomson Reuters, 2014) show that Clinical ... in Biochemistry , Biochemical Society Transactions ... in their Impact Factors. The journals are owned ... Press Limited. , 2014 Impact Factors (2013 Impact ...
(Date:7/30/2014)... decisions about what they eat, the Food and Drug ... the Nutrition Facts label found on nearly every food ... & Engineering News (C&EN), the weekly news magazine ... and the fight that has ensued. , Britt ... while the Nutrition Facts label has remained largely the ...
Breaking Biology News(10 mins):NexID Biometrics Joins the FIDO Alliance 2Across-the-board Impact Factor increases for Portland Press Limited 2
... Cornell University evolutionary biology research shows how plants at ... that influence ecosystem dynamics as well. ( Science, ... most organisms is dictated by their evolutionary history," said ... (EEB), the study,s senior author. In food webs, ...
... This release is available in Spanish . ... Agricultural Research and Development (Neiker-Tecnalia) has questioned the generally held ... exposure to natural light and states that the most determining ... Institute,s Department of Agricultural Production and Protection and opens up ...
... A protein discovered in fruit fly eyes has brought ... heart and other organs automatically "right size" themselves, a piece ... The protein, named Kibra, is linked to a relay ... by coordinating control of cell proliferation and death, according to ...
Cached Biology News:Move over predators: Plants can control the food chain too -- from the bottom up 2The quality of the tomato depends more on temperature than on natural light 2How does a heart know when it's big enough? 2
(Date:7/29/2014)... (PRWEB) July 30, 2014 ... and collaboration company, is proud to announce the ... management positions in their Boston, Charleston and Atlanta ... to the increased demand for hosted solutions, collaboration ... efficiency and reduce cost. , SoundConnect was founded ...
(Date:7/29/2014)... Bellingham, WA (PRWEB) July 29, 2014 ... manipulation of the brain that are driving a revolution ... a new peer-reviewed journal published by SPIE, ... The first issue coincides with the launch of the ... section features articles that lay out a vision for ...
(Date:7/29/2014)... Quantum Cheshire Cat: Can a particle be separated from ... Nature Communications , published the results of the first ... field, conducted by Chapman University in Orange, CA, and ... seen a cat without a grin," thought Alice in ... most curious thing I ever saw in my life!" ...
(Date:7/29/2014)... July 29, 2014  The Society for Clinical ... updated program for the 9 th annual ... in Amelia Island , Florida.  The focus ... remains unchanged, however, the topics and format will ... opportunity among all stakeholders with a continued focus ...
Breaking Biology Technology:SoundConnect Organization and Culture is Evolving 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 2TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 3
... (Nasdaq: ITMN ) today announced additions to ... of Esbriet™ (pirfenidone) in Europe.  InterMune,s Marketing Authorization Application ... is now awaiting ratification by the European Commission. ... of InterMune, said, "We are very pleased by the ...
... Dec. 17, 2010 RIFM, through its sponsorship of ... announce the resulting paper, Integrating population modeling into ... al , published in Integrated Environmental Assessment and Management ... of this journal according to Wiley-Blackwell and SETAC, publishers, ...
... from the Institut Catal de Nanotecnologia (ICN), in Barcelona, has ... electric currents, a key step in developing the spin computers ... 17 issue of the journal Science. The authors are Marius ... is leader of the Physics and Engineering of Nanodevices Group ...
Cached Biology Technology:InterMune Announces Senior Leadership Appointments to Prepare for Launch of Esbriet™ (Pirfenidone) in Europe 2InterMune Announces Senior Leadership Appointments to Prepare for Launch of Esbriet™ (Pirfenidone) in Europe 3InterMune Announces Senior Leadership Appointments to Prepare for Launch of Esbriet™ (Pirfenidone) in Europe 4InterMune Announces Senior Leadership Appointments to Prepare for Launch of Esbriet™ (Pirfenidone) in Europe 5InterMune Announces Senior Leadership Appointments to Prepare for Launch of Esbriet™ (Pirfenidone) in Europe 6RIFM Co-Authors Environmental Article - Among Top 5 Most Downloaded 2A 'spin ratchet': A new electronic structure for generating spin current 2
Mouse monoclonal [TONI-1] to Angiotensin II Type 1 Receptor (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 185 SwissProtID: P30556...
TGF-beta 1,-2,-3 MAb (Clone 1D11)...
HSV-1 gE Envelope Protein (9H3)...
... by their capacity to self renew and ... progenitor cells, which can commit to further ... (NSCs) are capable of differentiating into multiple ... During the isolation and expansion of NSCs, ...
Biology Products: