Navigation Links
Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants
Date:3/18/2009

obile and set up developmental patterns when they move through neighboring cells."

Ta-siRNAs behave like morphogens

These native, or endogenous, small RNAs are called trans-acting small interfering RNAs (ta-siRNAs). Like microRNAs and endogenous siRNAs present in other organisms, they regulate gene activity via a mechanism called RNA interference. Because of their newly discovered properties in leaf patterning, Timmermans likens the ta-siRNAs to "morphogens" or form-generating substances. Morphogens have been well studied in animals, although to date, scientists have only discovered protein and hormone morphogens. These molecules operate as positional signals whose effect on target cells is concentration-dependent. Secreted at a defined location, their movement establishes a concentration gradient that patterns a developing tissue such that cells closest to the morphogen's point of origin become distinct from cells that are farther away.

The CSHL team has now found that in plant leaves, ta-siRNAs similarly generate a concentration gradient that divides the developing leaf into a top and bottom half with different specialized cell types.

A ta-siRNA 'gradient' determines the ups and downs of developing leaves

The function of these ta-siRNAs is to specifically block the activity of a gene called ARF3. This gene defines the identities of cells found in the bottom half of leaves. For the correct leaf pattern to develop, it is therefore crucial that ARF3 is switched "on" in the right cells those at the leaf's lower side and turned "off" everywhere else.

"Without ta-siRNAs, leaves look like needles, because they lack an upper side," Timmermans says. "But we didn't understand how they set up patterning." This raised the question, in other words, of why ta-siRNAs only switch off ARF3 on the upper side of leaves. The CSHL team's finding that these RNA molecules seem to act as morphogens now solves the puzzle.
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps research scientists watch as individual alpha-synuclein proteins change shape
2. Gladstone scientists reveal key enzyme in fat absorption
3. Geoscientists discuss sea level rise, extreme storm events and more
4. Scientists gather to protect global food security from return of devastating wheat fungus
5. Antibody key to treating variant CJD, scientists find
6. Undesirable evolution can be reversed in fish, Stony Brook University scientists show
7. Lincoln Park Zoo scientists awarded National Institutes of Health grant
8. JCVI program trains USDA scientists on eukaryotic genome analysis
9. Monash scientists debug superbug
10. Scientists at CSHL discover mobile small RNAs that set up leaf patterning in plants
11. Scientists unlock the secrets of C. difficiles protective shell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... CHICAGO , August 5, 2015 ... Identity & Access Management Market by Software, Services, Vertical (BFSI, ... Chemical/Pharma), & Geography - Global Forecast to 2020", published ... Access Management Market globally into various segments. The global ... in 2014 to $546.2 Million by 2019, at a ...
(Date:8/3/2015)... 2015 Synaptics, Inc. (Nasdaq: SYNA ), ... that members of the executive management team will present ... Technology Leadership Forum on Tuesday, August 11, 2015 at ... at the Sonnenalp Resort in Vail, CO. ... forward-looking information. An audio webcast of the event will ...
(Date:7/31/2015)... SHENZHEN, China , 31 de julio de 2015 /PRNewswire/ ... www.icg-10.org ) se celebrará por medio de BGI del 22 ... China . Este año, la conferencia ... 2006, ICG se ha convertido en una de las reuniones ... de ser una de las reuniones más dinámicas, entusiastas y ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3
... at several sites in Pacific Ocean waters off the ... This study is the first to look at caffeine ... conducted by Portland State University master,s student Zoe Rodriguez ... professor of Environmental Science and Management, in collaboration with ...
... of carbon dioxide (CO 2 ) the main cause of ... high of 34 billion tonnes in 2011. In China, the world,s ... 9% to 7.2 tonnes per capita. China is now within the ... major industrialised countries. In the European Union, CO 2 emissions ...
... meeting of the Society for Neuroscience, is the world,s largest ... Learn how the brain works and new developments on ... mental illness, among others. More than 16,000 new discoveries ... world. , Credentialed media can access press conferences and ...
Cached Biology News:PSU study finds 'caffeinated' coastal waters 2Global CO2 emissions continue to increase 2Media registration opens for Neuroscience 2012, world's largest brain science meeting 2
(Date:8/31/2015)... DIEGO , Aug. 31, 2015 MabVax ... development company announces that the Company,s lead antibody, HuMab ... of five separate presentations during the upcoming World Molecular ... September 2-5, 2015. Researchers from the Department ... will present results on the use of MabVax,s lead ...
(Date:8/31/2015)... -- For people with Down syndrome, news from Elixirgen, ... located in the Science + Technology Park at Johns ... yet for people with Down syndrome and other chromosome disorders ... and Edwards syndrome aneuploidies in human cell cultures, " ... plans to develop this technology into a treatment for ...
(Date:8/31/2015)... , Aug. 31, 2015 FLX Bio, Inc., ... of novel cancer immunotherapies, announced today that it has ... Executive Officer and William Ho , M.D., Ph.D., ... an experienced management team led by veterans of Flexus ... Ph.D., Chief Scientific Officer; Jay Powers , Ph.D., ...
(Date:8/31/2015)... ... August 31, 2015 , ... There’s a new treatment option ... the first commercially available new FDA approved system in the last 14 years, and ... the high Amenorrhea (zero bleeding) rate of 66%, the high Patient Satisfaction rate of ...
Breaking Biology Technology:MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4New Down syndrome therapy discovered 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 3FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 4U.S. FDA Approves Minerva Endometrial Ablation System 2U.S. FDA Approves Minerva Endometrial Ablation System 3
... Pharmaceuticals, Inc. (Nasdaq: MAPP ) today announced financial results ... The net loss for the fourth quarter ended December 31, ... period in 2009. The net loss for the year ended December ... year ended December 31, 2009.   The increase in net loss ...
... at North Carolina State University have developed a ... their alignment and density. The researchers hope the ... of device applications using nanowires, from nanoelectronics to ... plastic and paper. "Alignment is a critical ...
... HONG KONG, Feb. 28, 2011 /PRNewswire-Asia-FirstCall/ -- China Cord Blood ... China,s leading provider of cord blood collection, laboratory testing, hematopoietic ... unaudited financial results for the third quarter and first nine ... Third Quarter of Fiscal ...
Cached Biology Technology:MAP Pharmaceuticals Reports 2010 Fourth Quarter and Year End Financial Results 2MAP Pharmaceuticals Reports 2010 Fourth Quarter and Year End Financial Results 3MAP Pharmaceuticals Reports 2010 Fourth Quarter and Year End Financial Results 4MAP Pharmaceuticals Reports 2010 Fourth Quarter and Year End Financial Results 5MAP Pharmaceuticals Reports 2010 Fourth Quarter and Year End Financial Results 6MAP Pharmaceuticals Reports 2010 Fourth Quarter and Year End Financial Results 7Stretched rubber offers simpler method for assembling nanowires 2China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 2China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 3China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 4China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 5China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 6China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 7China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 8China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 9China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 10China Cord Blood Corporation Reports Third Quarter and First Nine Months of Fiscal 2011 Financial Results 11
Human Glypican 2 Biotinylated Affinity Purified PAb...
B2-Microgloulin...
... Molecular Imaging's proprietary Focus™ detector technology, while ... the R4. The microPET Focus 120 ... avaiable PET scanner. Focus scanners also ... scinitallor based PETsystems. The combination of ...
...
Biology Products: