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Scientists are first to observe the global motions of an enzyme copying DNA
Date:10/27/2009

his, Suo and colleagues applied mathematical equations to the fluorescently lit observations to assign time frames to each part of the process.

They determined that the rate-limiting step of dNTP placement occurs during a brief and subtle shift of amino acids that ensures correct alignment of all structures just before the nucleotide is placed.

The rate-limiting step also requires the most energy of any step in the dNTP placement process. Suo and colleagues measured energy requirements for the key steps preceding placement of the nucleotide and found that the step requiring the most energy is that same subtle alignment shift.

The Suo lab is now using these findings and the fluorescent marking system to explore the dynamics of replication when DNA is damaged.


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Contact: Zucai Suo
suo.3@osu.edu
614-688-3706
Ohio State University
Source:Eurekalert

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