Navigation Links
Scientists are first to observe the global motions of an enzyme copying DNA
Date:10/27/2009

re investigating that possibility now."

The research appears online today (10/27) in the journal PLoS Biology, published by the Public Library of Science.

Human cells contain enzymes called polymerases that perform the process of copying DNA. The double helix of the DNA contains the genetic instructions for building an organism, and when cells in any living being divide, they copy DNA to pass on those instructions to new cells.

During this replication, the two halves of the DNA strand separate, and each half becomes a template for a new partner. The polymerases are responsible for "reading" the templates to determine where to place nucleotides to create the matching partners resulting in the creation of two identical double helices.

Polymerases are divided among six families of enzymes based on their amino acid sequence and function: A, B, C, D, X and Y (the most recently discovered family).

The A family has been well-studied and takes care of most of the DNA copying. But enzymes in this family stall if they come across DNA damage, and that stalling endangers the replication process and could lead to cell death.

The Y family of polymerases, on the other hand, can step in to bypass damage and allow copying to continue. This keeps the cell alive but also has led scientists to wonder if these enzymes could also be a major source of mistakes.

Polymerases are attractive research subjects because they have already been used as targets in anti-cancer and anti-viral drugs, so fully understanding their behavior could open up avenues for further drug development, noted Jessica Brown, a doctoral student in the Ohio State Biochemistry Program and a co-author of the study.

"In the case of polymerases, you want to know how these dynamics relate to the correct nucleotide incorporation so you can then determine the dynamics when the wrong molecule is incorporated," Brown said.

The research
'/>"/>

Contact: Zucai Suo
suo.3@osu.edu
614-688-3706
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Boston University scientists first to see RNA network in live bacterial cells
2. Scientists create NICE solution to pneumonia vaccine testing problems
3. Scientists of the UGR obtain a bioinsecticide to control the Mediterranean fruit fly
4. Queens scientists on international team discover ecologically unique changes in Arctic lake
5. UF scientists discover new explanation for controversial old patient-care technique
6. UF receives $12.2 million to establish national network of scientists
7. Caltech scientists create robot surrogate for blind persons in testing visual prostheses
8. Time in a bottle: Scientists watch evolution unfold
9. Scientists demonstrate link between genetic defect and brain changes in schizophrenia
10. Scientists remove amyloid plaques from brains of live animals with Alzheimers disease
11. UNC scientists win $1.6 million stimulus award to accelerate decoding of human genome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... emergency contraceptive pills in Peru found that 28 ... substandard quality or falsified. Many pills released the ... active ingredient. One batch had no active ingredient ... drugs, researchers at the Georgia Institute of Technology ... quickly assess suspected counterfeit drugs and then characterize ...
(Date:4/18/2014)... Ancient DNA adds a twist to the story of how ... published April 21 in the journal Proceedings of the ... bones of chickens that lived 200-2300 years ago in Europe, ... chickens may have looked far different from the chickens we ... traits we associate with modern domestic chickens -- such as ...
(Date:4/17/2014)... 17 In the most densely forested and most ... two centuries of human needs, values and practices. Disturbances ... forests for agriculture and development, have set the stage ... Forest Service study reports. , The report Five ... management needs in the Northern United States ...
Breaking Biology News(10 mins):Counterfeit contraceptives found in South America 2Counterfeit contraceptives found in South America 3Ancient DNA offers clues to how barnyard chickens came to be 2Five anthropogenic factors that will radically alter northern forests in 50 years 2Five anthropogenic factors that will radically alter northern forests in 50 years 3
... MANHATTAN, Kan. -- If cats really had nine lives, one ... of diseases that threaten feline health. Yunjeong Kim, a ... Kansas State University, has developed a research approach that tackles ... work is being supported by a $156,342 award from the ...
... ensure that the benefits of genetic resources are shared in ... the Convention on Biological Diversity, though questions remain about how ... new report from the Synthetic Biology Project at the Woodrow ... may affect U.S. researchers working in the field of synthetic ...
... (4 November 2013) The Population Council, an international ... development issues, will present findings from more than 40 ... Addis Ababa, Ethiopia (November 12-15, 2013). Notable ... in programs that strengthen gender equity; improve financing mechanisms ...
Cached Biology News:College of Veterinary Medicine researcher doubles down on deadly, infectious cat diseases 2College of Veterinary Medicine researcher doubles down on deadly, infectious cat diseases 3Population Council to present more than 40 studies at International Conference on Family Planning 2Population Council to present more than 40 studies at International Conference on Family Planning 3Population Council to present more than 40 studies at International Conference on Family Planning 4
(Date:1/15/2014)... CA (PRWEB) January 15, 2014 ... research solutions, today announced that Lupin Limited, one of ... Freeslate’s CM Protégé PharmD System for high ... Mumbai, India, is focused on a wide range of ...
(Date:1/14/2014)... 14, 2014 Carahsoft and CDS Federal ... 23, 2014 at 2pm EST (11am PST), “Natural Language ... focuses on how technology can turn raw, heterogeneous data ... government agencies. The online webinar will last approximately one ...
(Date:1/14/2014)... NY (PRWEB) January 14, 2014 EquitiesIQ, ... Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging biomedical ... serve the wound care market. , Free report download: ... restructured with a seasoned management team and Board, which ...
(Date:1/14/2014)... In recent years, growing suspicion about ... product development and promotion has led to unprecedented levels ... by concerns about the insidious impact of commercialization of ... fines to the world’s biggest pharmas for illegal marketing ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... Tornado-Torn ... Health Care Facility, MALVERN, Pa., Jan. ... a devastating 2007 tornado,Siemens has announced that, as part of its ... new MAGNETOM ESSENZA, worth,approximately $800,000., Siemens took notice of Sumter,s ...
... talent and investors to state, TOPEKA, Kan., ... announced today a "Come Home to Kansas" initiative ... investors to Kansas. Partners in this project include ... the Kansas,Bioscience Organization and the KTEC PIPELINE., ...
... Inc.,(Nasdaq: CRDC ) today reported financial results ... and six months ended December 31, 2007., ... over 1,000,C-Port systems shipped in the past quarter ... to enable minimally-invasive cardiac surgery and,substantial advancement for ...
Cached Biology Technology:A Magnetic Gift: Sumter Regional Hospital Receives New MRI as Charitable Donation From Siemens 2'Come Home to Kansas' Announced by KTEC 2Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 2Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 3Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 4Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 5Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 6Cardica Announces Fiscal 2008 Second Quarter Financial Results and Business Progress 7
MOUSE ANTI RAT RT1Bu Immunogen: Rat thymocyte membrane glycoproteins...
RABBIT ANTI HUMAN CYTOCHROME P450 1A1/2 Immunogen: Purified human CYP1A2 expressed in E.Coli ...
RABBIT ANTI HUMAN APP (KP1 DOMAIN) Immunogen: Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP....
... The Light Diagnostics Cytomegalovirus (CMV) pp65 Antigenemia ... qualitative identification of lower matrix protein pp65 ... Kit Components: ... One bottle containing 220 mL of buffered ...
Biology Products: