Navigation Links
Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
Date:4/24/2012

A method for the analysis of flavanols in cocoa has been developed by a team of researchers from Mars Botanical, a scientific division of Mars, Incorporated, and recently published in the Journal of AOAC International. Drawing on the research team's expertise in flavanol chemistry and analytics, the method identifies and quantifies the distinct stereochemical forms of flavanols found in cocoa and chocolate products. Foods rich in flavanols are increasingly recognized for their ability to exert positive effects on the cardiovascular system, but investigations have shown that the distinct chemical structure (stereochemistry) of a flavanol influences its absorption, metabolism, and consequently its ability to exert beneficial effects. This validated method could therefore have important implications for future investigations.

"By clearly identifying the specific stereochemical forms of flavanols in cocoa, this method can help establish stronger connections between cocoa flavanols and cardiovascular health. Our goal was not only to develop a method that could be used by Mars, but instead to validate one that could be widely implemented using standard analytical equipment in order to advance research in this field," commented Dr. Catherine Kwik-Uribe, study author and R&D Director at Mars Botanical.

Flavanols are a group of natural compounds that can be particularly abundant in cocoa and are also found in foods such as grapes, apples, and tea. Data from epidemiological studies and dietary interventions demonstrate that flavanol-rich foods can have a positive impact on cardiovascular function and health. Importantly, however, the flavanols in foods have different stereochemical forms, specifically ()-epicatechin and (+)-epicatechin, and ()-catechin and (+)-catechin. Some of these forms, notably ()-catechin and (+)-epicatechin, are present in foods almost exclusively as a result of food processing.

However, these stereochemical changes are more than just interesting chemical conversions. Previous research has identified ()-epicatechin as a critical, biologically active component of cocoa that is capable of mediating improvements in cardiovascular function. A collaborative study published in January 2011 by researchers from the University of California, Davis and Mars, Incorporated went one step further and revealed the crucial importance of flavanol stereochemistry. Specifically, the 2011 study highlights that, of the stereochemical forms of epicatechin and catechin, (−)-epicatechin is the most absorbed by the body almost six times more than ()-catechin. This clear demonstration of the profound impact of stereochemistry on flavanol absorption reinforces the need to identify and quantify the exact flavanol forms present in foods when considering their cardiovascular health impact. The recently published Journal of AOAC International paper provides a validated method for exactly this.

"This newly validated method addresses important gaps in our knowledge. In particular, it helps improve our understanding of the impact of food processing on the flavanol content of foods such as cocoa a crucial step towards the development of optimized food products to support health", commented Dr. Kwik-Uribe. "What's more, by identifying which flavanols are actually in the foods we eat, methods such as this enable a more detailed look at epidemiological studies and intervention trials. This brings us closer to being able to provide meaningful dietary recommendations."

The method has been published in the Journal of AOAC International. This research was conducted by a team of researchers from Mars Botanical, a scientific division of Mars, Incorporated, and forms part of a wider body of work examining cocoa flavanols, their chemistry and benefits to health.


'/>"/>
Contact: Elizabeth Willett
Elizabeth.willett@mss.effem.com
301-768-9100
Mars Symbioscience
Source:Eurekalert

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, Biometrics & ... & Other Service  The latest report from ... of the global Border Security market . Visiongain ... billion in 2016. Now: In November 2015 ... and hardware technologies for advanced video surveillance. ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
(Date:5/9/2016)... -- Elevay is currently known as the ... high net worth professionals seeking travel for work   ... there is still no substitute for a face-to-face meeting. ... deal with a firm handshake. This is why wealthy ... citizenship via investment programs like those offered by the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm ... Mold) microbial test has received AOAC Research Institute approval 061601. , “This is ... last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The ...
(Date:6/23/2016)...   EpiBiome , a precision microbiome engineering company, ... financing from Silicon Valley Bank (SVB). The financing will ... its drug development efforts, as well as purchase additional ... has been an incredible strategic partner to us – ... would provide," said Dr. Aeron Tynes Hammack , ...
(Date:6/23/2016)... ... ... In a new case report published today in STEM CELLS Translational Medicine, doctors ... being treated for breast cancer benefitted from an injection of stem cells derived from ... frequent side effect of cancer treatment. , Lymphedema refers to the swelling ...
Breaking Biology Technology: