Navigation Links
Scientists a step closer to understanding 'natural antifreeze' molecules
Date:6/23/2011

nts, such as glycerol, lowers the freezing temperature of water and prevents crystallisation by producing a 'syrupy' semi-solid state. The challenge is to know which cryoprotectant molecule to use and how much of it is necessary.

"We want to get this right so that we recover as much of the biological material as possible after re-thawing. This has massive cost implications, particularly for the pharmaceutical industry because at present they lose a large proportion of their viable drug every time they freeze it."

Dr Dougan and her team tested a range of different osmolytes to find out which ones are most effective at protecting the 3D structure of a protein. They used an atomic force microscope to unravel a test protein in a range of different osmolyte environments to find out which ones were most protective. They discovered that smaller molecules, such as glycerol, are more effective than larger ones like sorbitol and sucrose.

Dr Dougan said: "We've been able to show that if you want to really stabilise a protein, it makes sense to use small protecting osmolytes. We hope to use this discovery and future research to develop a simple set of rules that will allow scientists and industry to use the best process parameters for their system and in doing so dramatically increase the amount of material they recover from the freeze-thaw cycle."


'/>"/>

Contact: Hannah Isom
h.isom@leeds.ac.uk
44-011-334-35764
University of Leeds
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists uncover an unhealthy herds hypothesis
2. Qld fruit fly scientists in race against time
3. UC Riverside neuroscientists discovery could bring relief to epilepsy sufferers
4. Scientists breakthrough attracts new funding for high blood pressure research
5. Scientists develop a fatty kryptonite to defeat multidrug-resistant Super bugs
6. Scientists learn how horseweed shrugs off herbicide
7. Scientists pitch in to help keep salad mixes safe to eat
8. Top Latin-American scientists named 2011 Pew Fellows in the Biomedical Sciences
9. 22 of Americas most promising scientists selected as 2011 Pew Scholars in the Biomedical Sciences
10. Scientists find deadly amphibian disease in the last disease-free region of central America
11. Social scientists study impact of human adult stem cell research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... MOUNTAIN VIEW, Calif. , Aug. 5, 2015 /PRNewswire/ ... it exhibits continuous growth in applications, penetration into newer ... year after year. The global biosensors space has seen ... having exited the market so far. (Photo ... from Frost & Sullivan, Analysis of the Global ...
(Date:8/3/2015)... 2015 Synaptics, Inc. (Nasdaq: SYNA ), ... that members of the executive management team will present ... Technology Leadership Forum on Tuesday, August 11, 2015 at ... at the Sonnenalp Resort in Vail, CO. ... forward-looking information. An audio webcast of the event will ...
(Date:7/31/2015)... , 31 de julho de 2015 A ... www.icg-10.org ) será realizada pela BGI de 22-25 de outubro ... A conferência está celebrando seu 10 o. ... a ICG se tornou uma das reuniões mais influentes ... encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
Breaking Biology News(10 mins):Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... scientists to monitor how individual cells react in the complex ... much larger spectrum of differences between each cell than ever ... fashion, as was previously thought. "Think of cells as ... professor of bioengineering and senior author of the study, which ...
... June 26 Consuming higher amounts of omega-3 fatty ... for women with type 1 diabetes, according to a ... being presented at the 70th Scientific Sessions of the ... included 601 men and women enrolled in the Pittsburgh ...
... plant diversity in a forest? It,s a question even ... forest diversity demonstrates only patterns of species survival and ... now. A team of researchers led by biologists ... soil-borne pathogens are one important mechanism that can maintain ...
Cached Biology News:Same types of cell respond differently to stimulus, Stanford study shows 2Same types of cell respond differently to stimulus, Stanford study shows 3Soil-borne pathogens drive tree diversity in forests, study shows 2
(Date:9/2/2015)... Sep. 02, 2015 ... has announced the addition of Jain PharmaBiotech,s ... and Companies" to their offering. ... technologies besides fluorescence in situ hybridization (FISH), ... Molecular cytogenetics includes application of nanobiotechnology, microarrays, ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... and plant-derived compounds. BCC Research reveals in its new report that the ... market defines the category and generates the most market demand. , BCC ...
(Date:9/2/2015)... , Sept. 2, 2015 Australian prostate cancer ... prestigious Australian science prize recognising ,outstanding, science that uses ... to globally launch a novel prostate cancer diagnostic test ... high level consortium taking out the peer-reviewed Australian Museum ... Research. This prize is awarded for ...
(Date:9/2/2015)... FRANCISCO, Calif. , Sept. 2, 2015 ... Bonnie H. Anderson , president and chief executive ... Conference on Wednesday, September 16, 2015 at 10:30 a.m. ... The live audio webcast and subsequent ... . The webcast will be available shortly after conclusion ...
Breaking Biology Technology:Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 2Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 3Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 3Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3Veracyte to Present at Morgan Stanley Global Healthcare Conference 2
... everyday products from computers to shampoo can adversely affect the ... Research by the University of Edinburgh suggests that industrial manufacturers ... types of nanoparticles pose to workers who handle them. ... width of a human hair are potentially hazardous to ...
... smaller the need to understand nanoscale phenomena becomes greater ... nanoscale than they do at larger scales, new techniques ... phenomena. A team of researchers led by Paul Weiss, ... a tool to study nanoscale interactions. Their device is ...
... DIEGO, Nov. 17, 2010 Nanotrope, Inc. announced today ... covering its ground-breaking diagnostic test for influenza and other ... that creates an artificial "cell" engineered with specific membrane ... infecting the mimic as it would a normal host ...
Cached Biology Technology:Nanoscale probe reveals interactions between surfaces and single molecules 2Nanotrope, Inc. Receives Patent on New Diagnostic Test for Influenza and Other Viral Infections 2
Ps-Aeruginosa (IgA) -Ab EIA Sample Size: 100 l...
... bench time to just 15 minutes! The ... that can be drawn between this exciting new ... instant foods. Instant meals consumed by astronauts, ... and are reconstituted by adding water. The ...
Automated -80° C sample library for microplates and cryotube racks in SBS format; for integration into automated processes....
Candida (IgA) -Ab EIA Sample Size: 5 l...
Biology Products: