Despite several example in the scientific literature referring to the existence of a link between the low presence of AGPO-3 in the diet and depressive disorders, Susana Mato recognises that "little more is known about how modern Western diets, poor in AGPO-3, affect brain function and what might be the reason for a greater rate of depression associated with a deficit of these fatty acids".
As doctor Rodrguez-Puertas points out, "thanks to the results of this research new possibilities are opened up for undertaking deeper research, such as how diet modifies the functioning of the brain in general and the endocannabinoid system in particular, and how this is linked to mental disorders".
It also, "reinforces the idea that manipulating the endocannabinoid system can be useful for the treatment of depressive disorders, although the data we have up to now is very green for us to say what would be the ideal way to do so", pointed out Dr Mato.
Collaboration amongst European researchers
The research work started with two French teams located in Bordeaux and led respectively by doctors Olivier J Manzoni and Sophie Lay. They have been working for a number of years with mice which show low levels of AGPO-3 in their brain, due to a low diet in these fatty acids.
"Dr Manzoni's team discovered that the synaptic plasticity of the neuronal connections, which is mediated by endocannabinoids, disappears in these animals", pointed out Dr S. Mato. To this end, in 2008, they made contact with researchers at the Faculty of Medicine at the UPV/EHU in order to obtain their collaboration in undertaking new research in order to identify possible change sin the expression and activity of the cannabinoid receptors.
In fact, in order to draw conclusions from the study, it has been necessary to employ a large number of research tec
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