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The link between deficits of omega-3 poly-unsaturated fatty acids (AGPO-3) and the onset of depressive disorders is not new in the medical field. However, what has not been known until now is the brain mechanism by which diet can condition mental health to a certain extent. Research undertaken by scientists in Bordeaux (France) and at the Faculty of Medicine and Odontology of the University of the Basque Country (UPV/EHU) and published in Nature Neuroscience, provides new clues to understanding this phenomenon.
The name of the research work, 'Omega-3 nutritional deficiencies annul the neuronal functions of the endocannabinoid system' describes the research findings, endocannabinoid system being linked to the onset of depressive disorders.
According to Doctor Susana Mato, researcher in the Ramn y Cajal programme, attached to the Neurosciences Department of the Faculty of Medicine and Odontology at the UPV/EHU and member of the Neurobiology Group, "we have observed that, in mice subjected to a diet low in omega-3 poly-unsaturated fatty acids, they have lower AGPO-3 brain levels, and this fact is associated with an alteration in the functioning of the endocannabinoid system". More concretely, the researcher points to the confirmation of "the existence of a deficit in the signalling of the CB1 cannabinoid receptor in the prefrontal cortex of the brain. This protein the CB1 cannabinoid receptor has been linked, over the last decade and in various studies, to depressive disorders."
Doctor Rafael Rodrguez-Puertas, research worker responsible for the Neurochemical and Neurodegeneration team at the Faculty of Medicine and Odontology at the UPV/EHU, points out that "certain forms of synaptic plasticity a change in the efficiency of neuronal communication measured by the brain's endocannabinoid
|Contact: Oihane Lakar|