Navigation Links
Schizophrenia genetic networks identified; Connection to autism found
Date:11/11/2012

ifferent functional consequences, from rapid acceleration to stalling."

Dr. Vitkup looked at large mutations called copy number variants (CNVs) that can lead to either schizophrenia or autism. CNVs involve long stretches of the genome containing several genes that have been either duplicated or deleted. Duplication of a region increases the "dosage" of its genes; deletion of a region decreases the dosage.

In CNVs involved in the growth of dendrites, or dendritic spines, at the ends of neurons, he found decrease in growth to be more common in schizophrenia and increase in growth more common in autism. "That's consistent with what's been found by postmortem brain studies," he said.

"Evidence of functional convergence among risk genes is consistent with the notion that schizophrenia and autism are both primarily diseases of neuronal communication. However, they have distinct clinical features and the challenge remains to identify the critical neural circuits and mechanisms that differentiate them," said Dr. Joseph A. Gogos. "This is a step in that direction."

Dr. Vitkup predicts that many more genes involved in schizophrenia and autism will eventually be foundpossibly up to 1000 genes for each disorderbut a significant fraction of them will likely fall into the networks and pathways identified in the current study.

"Until a few years ago, people were looking for just a handful of genes responsible for autism and schizophrenia, so the idea that many hundreds of genes are involved is a big change in thinking," Dr. Vitkup said. "Our study and the studies of our collaborators suggest that in the search for the causes of complex genetic disorders, it will be more productive to look for common pathways and gene circuits than for a handful of causal genes. This type of network analysis gives us a way to begin to make sense of what's happening."

Study points way to future approaches to gene discovery

"To un
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Cannabis use mimics cognitive weakness that can lead to schizophrenia
2. Inflammation and cognition in schizophrenia
3. Researchers pursue red flag for schizophrenia relapse
4. Johns Hopkins researchers link 2 biological risk factors for schizophrenia
5. The music of the (hemi)spheres sheds new light on schizophrenia
6. Weber State Scientists discover possible building blocks of ancient genetic systems
7. Texas cotton getting a genetic tune-up
8. Renewal grant supports genetic research into arthritis of the spine
9. Verinata Health Announces New Findings At The American Society Of Human Genetics
10. Autism Speaks announces the release of new genetic data for researchers
11. Genetics Society of Americas GENETICS journal highlights for November 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ON), is pleased to inform ... State of Washington,s Department of Licensing, in the ... issuance system for driver,s licenses and identification cards to its ... development will start in January 2015, with enrollment and card ...
(Date:1/22/2015)... Wis. , Jan. 15, 2015  BellBrook Labs, ... drug discovery, announced the launch of a TR-FRET ... the company,s Transcreener UDP Assay, a high throughput ... The new assay will allow for sensitive detection ...
(Date:1/22/2015)... , Jan. 21, 2015  Analyst Report Issued by Small Cap ... report showed that planet-wide, transactions at merchants on the leading ... total number of credit, debit, and prepaid cards reached 6.54 ... victims of fraudulent card usage in 2012, and credit and ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2
... introduced ,Delicious, a new muscadine grape cultivar. ,Delicious, ripens ... fruit features exceptional taste and texture with an edible ... the potential for wine production. The name ,Delicious, was ... sampled the fruit., According to Dr. Dennis J. Gray, ...
... placed increasing demands on available water resources. In 2007, ... where the population approached two million people. The dual ... features frequent severe drought conditions has created an urgent ... meet resident and visitor demand., Las Vegas operates on ...
... vital component of good health. Like plants that thrive in ... case for the production of vitamin D. In the past ... sun exposure. From fear of the potential dangers of UV ... work and recreational environments centered on virtual reality, we are ...
Cached Biology News:Keeping golf courses green when fresh water is limited 2Keeping golf courses green when fresh water is limited 3The sunlight solution for better health 2The sunlight solution for better health 3
(Date:1/22/2015)... , Nueva Jersey , 22 de enero de ... Biomedical Research abre hoy su llamada a nominaciones para ... investigación científica ha hecho, o tiene el potencial para ... humana. Las nominaciones se aceptarán hasta el 15 de ...
(Date:1/22/2015)... 22, 2015   GenoSpace , a precision medicine software company ... the broad use of genomic, imaging and other biomedical data ... Michelle Munson , CEO of Aspera, an IBM Company, ... - http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased ...
(Date:12/24/2014)... Md. , Dec. 24, 2014  United Therapeutics Corporation ... Inc. (NYSE: MDT ) has submitted a ... Administration (FDA) for the use of Medtronic,s SynchroMed ® ... developed catheter) for use with United Therapeutics, Remodulin ® ...
(Date:12/24/2014)... Solutions , Inc. (NASDAQ: BLFS ), a leading ... storage and cryopreservation freeze media and ... or the "Company"), today announced that it will hold its ... "Annual Meeting"). Because the expected date for the ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... June 19, 2008,at 7:00 PM Central European Time/1:00 PM ... (CTI) (Nasdaq and MTA: CTIC),management team will host a ... at its Seattle headquarters located at 501 Elliott Ave.,West, ... on CTI,s website,at http://www.CellTherapeutics.com and archived for ...
... (Nasdaq: EXEL ) announced today that Frank Karbe, ... present at the,William Blair & Company 28th Annual Growth ... June 19, 2008. Mr. Karbe will discuss updates,to the ... will be webcast and may be accessed in the ...
... HRS Conference, MINNEAPOLIS, June 12 Braemar, ... BTEL) and a world leader in,ambulatory cardiac monitoring ... that integrates cardiac arrhythmia monitoring and,cell phone technologies ... loop recorder,with on-board arrhythmia detection algorithms for automatic ...
Cached Biology Technology:Cell Therapeutics, Inc. Special Meeting in Lieu of Annual Meeting of Shareholders Scheduled for Thursday, June 19, 2008 2Braemar Introduces the ER920W Wireless Cardiac Arrhythmia Monitor 2
... for use in the Microsart e.motion are sterile-sealed, ... in a specially designed individual package on a ... band of membrane filter units ensures that they ... the sealed band guarantees uniform dispensing of the ...
... Mouse monoclonal [RS17 ] to PRKAR2 ... for a variety of cellular functions. cAMP ... protein kinase (AMPK), which transduces the signal ... inactive holoenzyme of AMPK is a tetramer ...
... Rocking Shaker provides the exact agitation ... The very slow to fast speed ... provide a gentle wave motion that ... blotted membranes to achieve faster, more ...
...
Biology Products: