Navigation Links
Schizophrenia genetic networks identified; Connection to autism found
Date:11/11/2012

alysis uncovers genetic networks

To discover potential connections among genes mutated in schizophrenia, Dr. Vitkup and colleagues developed a computational approach, called NETBAG+, to identify networks of genes likely to be responsible for the same genetic phenotype. They then gathered the strongest mutations that had been observed in schizophrenia by other researchersincluding a set of de novo mutations recently described by a team of Columbia researchers led by Maria Karayiorgou, MD, and Joseph A. Gogos, MD, PhDand fed them into the program.

The program uncovered two genetic networks. Genes in the first network are involved primarily in axon guidance, synapse function, and cell migration. Genes in the second network are involved in chromosomal organization and remodeling.

Parts of both networks are highly active during prenatal development, suggesting that changes in the brain that cause schizophrenia later in life are laid down very early in life.

Connection to autism

Dr. Vitkup also compared his schizophrenia networks with networks found in neurodevelopmental disorders such as autism. One schizophrenia network is strongly related to an autism network he described in a study published last year. Both networks contain genes involved in axon guidance, synapse function, and cell migration.

"Our recent mutational analysis showed that this overlap includes primarily genes that are important for early fetal development. This is not surprising, because some cases of schizophrenia and likely many cases of autism have neurodevelopmental origin," said Dr. Karayiorgou.

The close relationship between genetic networks involved in autism and schizophrenia raises an intriguing question: How can mutations in the same or related genes cause two different disorders?

"I like to use the analogy of car brakes," said Dr. Vitkup. "Different mechanical malfunctions of the brake mechanism can have very d
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Cannabis use mimics cognitive weakness that can lead to schizophrenia
2. Inflammation and cognition in schizophrenia
3. Researchers pursue red flag for schizophrenia relapse
4. Johns Hopkins researchers link 2 biological risk factors for schizophrenia
5. The music of the (hemi)spheres sheds new light on schizophrenia
6. Weber State Scientists discover possible building blocks of ancient genetic systems
7. Texas cotton getting a genetic tune-up
8. Renewal grant supports genetic research into arthritis of the spine
9. Verinata Health Announces New Findings At The American Society Of Human Genetics
10. Autism Speaks announces the release of new genetic data for researchers
11. Genetics Society of Americas GENETICS journal highlights for November 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... CAMBRIDGE, Mass-- Conventional wisdom has long held that ... of coral reefs are passive organisms that ... substances, such as nutrients and oxygen. But now ... Science (WIS) in Israel have found that they ... sweep water into turbulent patterns that greatly enhance ...
(Date:9/1/2014)... AM EDT) It may be possible to train ... higher-calorie foods, according to new research by scientists at ... Aging (USDA HNRCA) at Tufts University and at Massachusetts ... Nutrition & Diabetes , a brain scan study in ... to reverse the addictive power of unhealthy food while ...
(Date:9/1/2014)... electron microscopy revealed the presence of tiny blob-like structures ... scientists still don,t know what they do even ... to be crucial to the life of a cell, ... treatment., In the Journal of Cell Biology , ... various backgrounds, from biophysics to cell biology, to focus ...
Breaking Biology News(10 mins):Nature's tiny engineers 2Nature's tiny engineers 3Training your brain to prefer healthy foods 2Scientists call for investigation of mysterious cloud-like collections in cells 2
... has named its awardee for this year,s Alan ... Brown University. Dunn,s work involves genome analyses ... He investigates the origins of biological complexity ... research holds clues about how complex multicellular organisms, ...
... This release is available in French . ... without exposing the healthy surrounding tissue to the medication,s toxic ... medical reality, thanks to the work of Professor Sylvain Martel, ... Known for being the world,s first researcher to have guided ...
... most controversial aspects in the sustainable management of golf courses. ... the practices relating to reclaimed water at one of the ... on the course receive 83% more water than they need. ... be justified from any perspective", Mara del Pino Palacios Daz, ...
Cached Biology News:Casey Dunn to receive NSF Waterman Award 2Casey Dunn to receive NSF Waterman Award 3World first -- Localized delivery of an anti-cancer drug by remote-controlled microcarriers 2Golf courses that reuse water irrigate too much 2Golf courses that reuse water irrigate too much 3
(Date:8/29/2014)... (PRWEB) August 29, 2014 Three ... Energy's 2014 Hydrogen Production R&D Award ... by splitting water using sunlight. , Shared with ... and the University of Nevada, Las Vegas (UNLV), ... developing models of photoelectrochemical solar-hydrogen production and corrosion ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 A major ... the biotech start-up dense realm of Boston-Cambridge, is gaining ... able investors. James Sherley, the Director of Boston’s Adult ... the local and national visibility of his company an ... 2013. , In addition to a social media marketing ...
(Date:8/28/2014)... USA (PRWEB) August 28, 2014 SPIE ... of Physics and Optical Science and Director of the ... of North Carolina at Charlotte, and co-founder and Chairman ... to serve as the 2015 Vice President of SPIE, ... 2014 President Philip Stahl announced recent election results at ...
(Date:8/28/2014)... Ca. (PRWEB) August 28, 2014 Best ... rating for an alcohol-based hand sanitizer, asks food processors ... by comparing the hand sanitizer they’re currently using to ... . Hand hygiene is critical to fighting cross-contamination and ... Best Sanitizers believes there are key criteria that ...
Breaking Biology Technology:Livermore Team Awarded for Hydrogen Production Research 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3
... Emmanuel Labourier , Ambion, Inc , ... from the same sample Enrich for , ... , for assessing siRNA or miRNA expression and ... (siRNAs) and , microRNAs (miRNAs) have emerged as ...
... , High ... Only ethically sourced tissue is used , Custom RNA isolations from tissue ... Begins at the Source , Use ... that you are getting the highest , quality ...
... In Vitro Translation Kit , ... of protein than reticulocyte , lysate systems , ... biological activity than other E. coli , lysate systems ... researchers studying protein function and , ...
Cached Biology Technology:Isolate It All: siRNA miRNA , Total RNA Native Protein 2Isolate It All: siRNA miRNA , Total RNA Native Protein 3Isolate It All: siRNA miRNA , Total RNA Native Protein 4Isolate It All: siRNA miRNA , Total RNA Native Protein 5Isolate It All: siRNA miRNA , Total RNA Native Protein 6Isolate It All: siRNA miRNA , Total RNA Native Protein 7Isolate It All: siRNA miRNA , Total RNA Native Protein 8Isolate It All: siRNA miRNA , Total RNA Native Protein 9High Quality RNA Isolation Services 2Increase Protein Activity and Yield 2Increase Protein Activity and Yield 3
...
... contains the basic components required for the ... and recombinant canine Monocyte Chemotactic Protein 1 ... Each kit contains sufficient materials to run ... that the following conditions are met:2 ...
Mouse monoclonal [LPL4A.1] to Plastin L ( Abpromise for all tested applications). SwissProtID: P13796...
Component of HyperMu™ Insertion Kit...
Biology Products: